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BackgroundCognitive-behavioral therapy (CBT) and serotonin reuptake inhibitors (SRIs) are recommended treatments for pediatric obsessive-compulsive disorder (OCD), but their relative efficacy and acceptability have not been comprehensively examined. Further, it remains unclear whether the efficacy of in-person CBT is conserved when delivered in other formats, such as over telephone/webcam or as In

Electroencephalography (EEG) data entail a complex spatiotemporal structure that reflects ongoing organization of brain activity. Characterization of the spatial patterns is an indispensable step in numerous EEG processing pipelines. We present a novel method for transforming EEG data into a spectral representation. First, we learn subject-specific graphs from each subject's EEG data. Second, by e

IntroductionPatients with congenital heart disease (ConHD) are at increased risk for adverse cardiac events. Predicting long-term outcomes and guidance of patient management might benefit from a range of (new) biomarkers. This is a rapidly evolving field with potentially large consequences for clinical decision making. With a systematic review of available biomarkers in ConHD we identified the cli

Microorganisms play a crucial role in various physiological processes, including metabolism, immune defense, nutrition absorption, defense against cancer, and protection against pathogen colonization. Changes in microbial communities serve as potential biomarkers for diseases, offering significant insights into disease treatment and diagnosis. However, the association between microorganisms and di

Through ultrarelativistic particle collisions at the LHC, it is possible to deconfine quarks and gluons. This deconfinement gives rise to a strongly interacting medium, referred to as the Quark-Gluon Plasma (QGP). One of the earliest proposed and observed signatures of the QGP was the enhanced production of strange hadrons since the medium can thermally produce strange quarks. However, recent stud

This study developed an air-liquid interface (ALI) corneal model using explants bovine eyes for ocular toxicity assessment of ten chemicals and seven hair straightening mixtures. It was successfully maintained physiologically viable and normal for six days. Both eye damage (GHS cat. 1) and irritating (GHS cat. 2) chemicals induced corneal injury in our model. However, cat. 2 irritants triggered mo

The aim of this workshop was to discuss the needs and challenges in using high-resolution climate model outputs for impacts-relevant modeling. Development of impacts-relevant climate projections in the polar regions requires effective collaboration between regional climate modelers and impacts-relevant modelers in the design stage of high-resolution climate projections for the polar regions.

Recent studies have shown that dissolved organic matter (DOM) decomposed by ectomycorrhizal (ECM) fungi increases adsorptive properties of organic matter towards soil mineral surfaces. Concomitantly, ECM fungi secrete secondary metabolites with iron reducing capacity that are thought to participate in non-enzymatic Fenton-based decomposition of DOM. The aim of this study was to investigate if the

As the Internet of Things (IoT) era emerges the need for ultra-low power (ULP) devices is becoming more eminent. A research-proven approach to achieve ULP consumption is to aggressively lower the supply voltage (VDD) below or in the vicinity of the transistor threshold voltage (Vth) and operate the transistors in the subthreshold (sub-Vth) region. Operating below or near the threshold voltage, i.eAs the Internet of Things (IoT) era emerges the need for ultra-low power (ULP) devices is becoming more eminent. A research-proven approach to achieve ULP consumption is to aggressively lower the supply voltage (VDD) below or in the vicinity of the transistor threshold voltage (Vth) and operate the transistors in the subthreshold (sub-Vth) region. Operating below or near the threshold voltage, i.e

Scope: Multifunctional diet (MFD), a diet based on multiple functional concepts and ingredients with anti-inflammatory activity, was previously shown to improve different cardiometabolic risk-associated markers in healthy subjects. Here, we assessed the impact of MFD on plasma metabolome and explored associations of the differential metabolites with clinical parameters, searching for metabolic det

Theoretical investigations of the structure and function of the blue copper proteins are described. We have studied the optimum vacuum geometry of oxidised and reduced copper sites, the relative stability of trigonal and tetragonal Cu(II) structures, the relation between the structure and electronic spectra, the reorganisation energy, and reduction potentials. Our calculations give no support to t

Rearrangements of the transcription factors FOS and FOSB have recently been identified as the genetic driver event underlying osteoid osteoma and osteoblastoma. Nuclear overexpression of FOS and FOSB have since then emerged as a reliable surrogate marker despite limitations in specificity and sensitivity. Indeed, osteosarcoma can infrequently show nuclear FOS expression and a small fraction of ost

Co-infections with bacterial or fungal pathogens could be associated with severity and outcome of disease in COVID-19 patients. We, therefore, used a 16S and ITS-based sequencing approach to assess the biomass and composition of the bacterial and fungal communities in endotracheal aspirates of intubated COVID-19 patients. Our method combines information on bacterial and fungal biomass with communi

Malaria is considered to be one of the most catastrophic health issues in the whole world. Vibrational spectroscopy is a rapid, robust, label-free, inexpensive, highly sensitive, nonperturbative, and nondestructive technique with high diagnostic potential for the early detection of disease agents. In particular, the fingerprinting capability of attenuated total reflection spectroscopy is promising

The paper analyses the legal framework for the collection and distribution of remote sensing data, particularly in the field of sustainable development and environmental protection at the European level. The research firstly focuses on the historical evolution of space law at the international, European, and national levels, starting from the 1970s. In parallel, environmental law has rapidly devel

Motivated by the well established idea that collective wisdom is greater than that of an individual, we propose a novel learning dynamics as a sort of companion to the Abelson model of opinion dynamics. Agents are assumed to make independent guesses about the true state of the world after which they engage in opinion exchange leading to consensus. We investigate the problem of finding the optimal

In TSP with neighborhoods we are given a set of objects in the plane, called neighborhoods, and we seek the shortest tour that visits all neighborhoods. Until now constant-factor approximation algorithms have been known only for cases where the objects are of approximately the same size. We present the first polynomial-time constant-factor approximation algorithm for disjoint convex fat objects of

Few medications for treating alcohol dependence exist. Greater partnership is needed between academia and the pharmaceutical industry to develop, licence and market efficacious medications for treating alcohol dependence. Methodologies that span the divide between preclinical and large-scale clinical studies need to be developed in order to provide sufficient information on safety, toleration, dru