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The Lifetime of the Proton-decaying 8915 keV State in 58Cu

Energy correlations between gamma -ray transitions and the prompt proton decay line in Cu-58 were studied by means of the fusion-evaporation reaction Ca-40(Mg-24,1 alpha 1p1n) using the EUROBALL spectrometer coupled to ancillary detector devices. A lifetime of 0.06 < tau < 0.58 ps for the 8915 keV proton-decaying state in Cu-58 is deduced. (C) 2001 Elsevier Science B.V. All rights reserved.

Evaluation of capture ELISA for detection of antineutrophil cytoplasmic antibodies directed against proteinase 3 in Wegener's granulomatosis: first results from a multicentre study

Objective: To evaluate the performance characteristics of direct and capture ELISA for the detection of PR3-ANCA in Wegener's granulomatosis (WG) in international ANCA reference laboratories. Methods: Serum samples were derived from patients with histological and clinical diagnosis of WG (n = 60), rheumatoid arthritis (RA) (n = 30) and healthy controls (n = 30). Each of them was tested for the pre

Imatinib mesylate is effective in children with chronic myelogenous leukemia in late chronic and advanced phase and in relapse after stem cell transplantation

A multicentric phase 2 study was conducted to determine the efficiency and the tolerance of imatinib mesylate in children with chronic myelogenous leukemia (CML) in advanced phase of the disease, in relapse after stem cell transplantation, or in case of failure to an interferon a-based regimen. In all, 30 children from eight European countries were enrolled. In 18 children assessable for hematolog

Optimization toward a high-average-brightness soft-x-ray laser pumped at grazing incidence

We report the near-field imaging characterization of a 10 Hz Ni-like 18.9 nm molybdenum soft-x-ray laser pumped in a grazing incidence pumping (GRIP) geometry with a table-top laser driver. We investigate the effect of varying the GRIP angle on the spatial behavior of the soft-x-ray laser source. After multiparameter optimization, we were able to find conditions to generate routinely a high-repeti

Comparison between tower and aircraft-based eddy covariance fluxes in five European regions

Airborne eddy covariance measurements provide a unique opportunity to directly measure surface energy, mass and momentum fluxes at the regional scale. This offers the possibility to complement the data that are obtained by the ground-based eddy covariance networks and to validate estimates of the surface fluxes that can be obtained by means of satellite products and models. The overall accuracy an

Role of electronic localization and charge-vibrational coupling in resonant photoelectron spectra of polymers: Application to poly(para-phenylenevinylene)

A combination of x-ray absorption and resonant photoemission (RPE) spectroscopy has been used to study the electronic structure of the one-dimensional conjugated polymer poly (para-phenylenevinylene) in nonordered (as prepared) thin films. The dispersion of RPE features for the decay to localized and delocalized bands are qualitatively different. A theory for band dispersion of RPE in polymers is

A K-ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of langerhans

Glucagon, secreted from pancreatic islet a cells, stimulates gluconeogenesis and liver glycogen breakdown. The mechanism regulating glucagon release is debated, and variously attributed to neuronal control, paracrine control by neighbouring beta cells, or to an intrinsic glucose sensing by the a cells themselves. We examined hormone secretion and Ca2+ responses of a and b cells within intact roden

Structural and Functional Studies of Gas6

The vitamin K-dependent and ubiquitously expressed 82 kDa glycoprotein product of the growth-arrest-specific-gene 6, Gas6, shows 44% sequence identity to the anticoagulant protein, protein S. Both proteins share further the same domain organization. A short loop region, 4 epidermal growth factor-like modules and an SHBG-like region follow the N-terminal Gla-domain, which confers membrane-binding c

Quantitative study of 10 Hz operation of a soft x-ray laser-energy stability and target considerations

A soft x- ray laser from Ni- like Mo, pumped in grazing incidence ( GRIP), is analyzed with regard to high repetition rate operation. Reliable lasing is obtained, but with significant energy fluctuations attributed mainly to beam pointing jitter from the pump laser. Two modes of operation are compared: continuously moving target and stationary target. With a moving target the soft X- ray output is

A classification of hemolytic uremic syndrome and thrombotic thrombocytopenic purpura and related disorders

The diagnostic terms hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP) are based on historical and overlapping clinical descriptions. Advances in understanding some of the causes of the syndrome now permit many patients to be classified according to etiology. The increased precision of a diagnosis based on causation is important for considering logical approaches to tre

ERP Licensing Perspectives on Adoption of ERPs in Small and Medium-sized Enterprises

The ERP market has been changing since the implementation peaks observed around Y2K, when most of the high-end adopters take their chance of substituting legacy systems while implementing integrated management. This adoption movement from bigger companies created a reaction on the Small and Medium-sized Enterprises (SMEs) ERP market: on the vendor side, it was necessary to find new market segments

Temperature limited fed-batch cultivation with a probing feeding strategy for Escherichia coli

A cultivation strategy combining the advantages of temperature limitedfed-batch and probing control is presented.This is a suitable way to produce recombinant proteins while minimizing therelease of endotoxins which complicates the downstream processing.The downside with the temperature limited fed-batch technique has been the difficulty to achieve a controlled excess of glucose inthe reactor with

Preparation of the Gaia Data Processing: First Astrometric Results

The Gaia mission of the European Space Agency (ESA) will produce high-precision astrometry for 10^9 objects up to 20th magnitude. The volume of data generated (about 150TB of compressed raw data) and the complexity of the relationships between them make the scientific processing a challenging task. This paper presents the basic concepts of the core of the astrometric data reduction, the AGIS syste

An L-infinity Approach to Structure and Motion Problems in 1D-Vision

The structure and motion problem of multiple one- dimensional projections of a two-dimensional environment is studied. One-dimensional cameras have proven useful in several different applications, most prominently for autonomous guided vehicles, but also in ordinary vision for analysing planar motion and the projection of lines. Previous results on one-dimensional vision are limited to classifying

Evidence for scale- and disturbance-dependent trait assembly patterns in dry semi-natural grasslands

1. The mechanisms driving nonrandom assembly patterns in plant communities have long been of interest in ecological research. Competing ecological theories predict that coexisting species may either be more functionally dissimilar than expected by chance (with functional divergence' mainly reflecting niche differentiation) or be functionally more similar than expected (with functional convergence'

Influence of bioreactor scale and complex medium on probing control of glucose feeding in cultivations of recombinant strains of Escherichia coli

The objective of this work was to evaluate the performance of a feedback glucose control strategy (the probing strategy) in production relevant bioreactors with complex and mineral media. Experimental results from fedbatch cultivations with two recombinant Escherichia coli constructs expressing two different human therapeutic proteins were used to assess the performance and limitations of the gluc

Defective chromosome segregation and telomere dysfunction in aggressive Wilms' tumors

Purpose: In many childhood neoplasms, prognostic subgroups have been defined based on specific chromosome changes. In Wilms' tumor (WT), such subclassification has been hampered by the diverse and relatively unspecific pattern of chromosomal imbalances present in these tumors. Unspecific patterns of cytogenetic imbalances in tumors are often caused by mitotic segregation errors due to short dysfun

Determination of dissociation constants between polyelectrolytes and proteins by affinity capillary electrophoresis

In this manuscript we report the binding affinity between two model proteins, human serum albumin (HSA) and ribonuclease A (RNase A), and negatively charged polyelectrolytes, two different heparin fractions and dextran sulfate, by means of partial filling and affinity capillary electrophoresis. The apparent dissociation constants, Kd, obtained by use of the partial-filling method, between HSA and