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Objectives To perform fine mapping of the PXK locus associated with systemic lupus erythematosus (SLE) and study functional effects that lead to susceptibility to the disease. Methods Linkage disequilibrium (LD) mapping was conducted by using 1251 SNPs (single nucleotide polymorphism) covering a 862 kb genomic region on 3p14.3 comprising the PXK locus in 1467 SLE patients and 2377 controls of Euro

We develop a representation of reverse-time migration (RTM) in terms of Fourier integral operators, the canonical relations of which are graphs. Through the dyadic parabolic decomposition of phase space, we obtain the solution of the wave equation with a boundary source and homogeneous initial conditions using wave packets. On this basis, we develop a numerical procedure for the reverse-time conti

This report identifies fundamental problems to be addressed in order to build relevant clinical tests of human balance while standing. The stated purpose of these tests is identification of lesion site and/or definition of functional balance deficits in a specific patient. During a recent consensus meeting (ESCEBD), 60 researchers and experienced clinical users of posturography (14 European countr

The aim of this study was to determine the threshold of fracture probability at which interventions became cost-effective in men and women, based on data from Sweden. We modeled the effects of a treatment costing $500 per year given for 5 years that decreased the risk of all osteoporotic fractures by 35% followed by a waning of effect for a further 5 years. Sensitivity analyses included a range of

The solution properties of two water-soluble polymers, poly(acrylic acid) (PAA), covalently labeled with the fluorescent hydrophobic dye naphthalene (Np), have been investigated in water:organic solvent mixtures. The naphthalene chromophores have been randomly attached, onto the polymer, with two different degrees of labeling. Fluorescence measurements (steady-state and time-resolved) have been us

High-resolution physical, mineralogical, sedimentological and micropalaeontological studies were carried out on North Atlantic cores from the Reykjanes Ridge at 59degreesN and from the region southwest of the Faeroe Islands. All core sites are situated along the pathway of Iceland-Scotland Overflow Water (ISOW) and the various parameters measured display similar features. Previously identified car

In the present work non-idealities of flat burner-stabilized flames at atmospheric and low pressures are examined using PIV measurements, which are supported by and analyzed with the help of CFD modeling. Radial and axial velocity profiles measured in the cold flow and in the flames at atmospheric and at lower pressures are presented. Two possible reasons for the drop in the apparent laminar burni

Specific alterations (mutations, deletions, insertions) of virus genomes are crucial for the functional characterization of their regulatory elements and their expression products, as well as a prerequisite for the creation of attenuated viruses that could serve as vaccine candidates. Virus genome tailoring can be performed either by using traditionally cloned genomes as starting materials, follow

Cinnamoyl-CoA reductase (CCR), an enzyme central to the lignin biosynthetic pathway, represents a promising biotechnological target to reduce lignin levels and to improve the commercial viability of lignocellulosic biomass. However, silencing of the CCR gene results in considerable flux changes of the general and monolignol-specific lignin pathways, ultimately leading to the accumulation of variou

Although the main aim of clubfoot correction is to create a foot without limitations in daily activities and sport, studies on the walking capacity of children with corrected clubfeet are rare. In this cross-sectional study, the outcome of the six-minute walking test in 44 children with clubfeet (16 unilateral and 28 bilateral, mean age 8.57±2.45 years) was compared with the reference values of Ge

Ever since Goldin-Meadow, S., C. Mylander, W. C. So, and A. Özyürek. 2008. The natural order of events: How speakers of different languages represent events nonverbally. PNAS 105: 9163–9168. proposed that there is a preferred order in sequential non-verbal event representations (Actor > Patient > Act), apparently independent of the default word order in one’s native language, the topic has been th

Aquaporins of the TIP subfamily (Tonoplast Intrinsic Proteins) have been suggested to facilitate permeation of water and ammonia across the vacuolar membrane of plants, allowing the vacuole to efficiently sequester ammonium ions and counteract cytosolic fluctuations of ammonia. Here, we report the structure determined at 1.18 Å resolution from twinned crystals of Arabidopsis thaliana aquaporin AtT

Abstract Background: Cardiac resynchronization therapy (CRT) is effective, but only 60-70% of patients benefit from the therapy. Despite numerous implantations, identification of predictive factors for response is still a challenge. We sought to assess the correlation of echocardiographic and clinical response to baseline demographics in relation to change in NT-proBNP levels at 6 months. Methods:

Background. HIV-infected mothers can transmit their infection to their children in utero or at delivery (vertical transmission). There have been cases of children who were reported as acquiring infection vertically and later clearing the infection. We report the frequency of this phenomenon in a European cohort study. Methods. In four centres of the European Collaborative Study of children born to

Reason(s) for writing and research problem(s): This article analyzes the experiences retold by former concentration camp detainees who were placed in concentration camps like civilians at the beginning of the Bosnian war in the 1990s. Aims of the paper (scientific and/or social): The article aims to describe the recounted social interaction rituals after time spent in a concentration camp as well

Aquaporins are transmembrane proteins that facilitate the flow of water through cellular membranes. An unusual characteristic of yeast aquaporins is that they frequently contain an extended N terminus of unknown function. Here we present the X-ray structure of the yeast aquaporin Aqy1 from Pichia pastoris at 1.15 Å resolution. Our crystal structure reveals that the water channel is closed by the N

A new global atmospheric carbon dioxide (CO2) real-time forecast is now available as part of the pre- operational Monitoring of Atmospheric Composition and Climate – Interim Implementation (MACC-II) service us- ing the infrastructure of the European Centre for Medium- Range Weather Forecasts (ECMWF) Integrated Forecast- ing System (IFS). One of the strengths of the CO2 fore- casting system is that