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Objectives: Cystic fibrosis hepato-biliary involvement (CFHBI) is a common comorbidity in patients with CF and is associated with increased morbidity and mortality. The effect of the new and highly potent CF transmembrane conductance regulator modulator therapy, elexacaftor-tezacaftor-ivacaftor (ETI), on CFHBI, is still unclear. This study aimed to investigate the impact of ETI on liver stiffness

Declining butterfly abundance over recent decades coincides with both habitat loss and increasingly warmer springs. Warmer temperatures could pose a problem for ‘capital’ breeders, especially those species that enter winter diapause as a pupa or adult, since a higher metabolic rate pre-eclosion is expected to further deplete lipid stores needed for egg production. We undertook an experiment on Pie

Life on Earth is a mosaic distributed across biogeographical regions. Their regional species pools have experienced distinct historical and eco-evolutionary pressures, leading to an expected context-dependent organization of biodiversity. Here we identify a general spatial organization within biogeographical regions of terrestrial and marine vertebrates, invertebrates and plants (more than 30,000

In this work we report the solvothermal synthesis of iron oxide and zinc oxide using a ternary eutectic mixture of choline chloride, urea and glycerol at three molar ratio of the components 1 : 1 : 1, 1 : 1.5 : 0.5 and 1 : 0.5 : 1.5. The synthesised iron oxide is nanocrystalline with a crystallite size of 67.5 ± 8.9 nm, however ZnO formed larger particles. Water and surfactants can be added to the

Parents of children with disabilities may face higher labor-market penalties given the extra care and support required. Using Swedish administrative data, we focus on first-born children with Cerebral Palsy (CP) to estimate impacts on parental labor-market outcomes. We apply an event study approach to identify effects up to 10 years after the birth of the child. Our results show that employment an

Context. The bar pattern speed of the LMC has been computed based on data from Gaia DR3 using three different methods. One method suggested that the LMC might be hosting a bar that barely rotates, and is slightly counter-rotating with respect to the disc of the LMC, with a pattern speed of Ωp = −1.0 ± 0.5 km s−1 kpc−1. Aims. We aim to confirm that tidal interactions might prevent the bar hosted by

High-speed vertical In–Ga–As nanowire MOS field-effect transistor (MOSFET) measurements were analyzed through parametric layout models. Measurements from small and large transistors were used to fit dependencies on the number of gate fingers and the number of wires per finger. Extrapolations via intrinsic and parasitic elements reveal the optimal layout for peak frequency performance. To achieve a

How does new technology impact labor market outcomes? We address this question by examining the adoption of electricity in Sweden during the early 20th century. Leveraging detailed individual-level data that covers the entire labor market and exogenous variation in electricity access driven by proximity to hydro-power plants, we estimate the impact of electrification on individual labor market out

Background: Monitoring metabolites of tamoxifen, such as endoxifen, has been suggested as a strategy to ascertain therapeutic effect of tamoxifen therapy, but clinical guidelines are missing. Herein, we aim to investigate the outcome of endoxifen concentrations of low-dose tamoxifen, using change in mammographic breast density as a proxy for therapy response. Methods: In the randomized KARISMA-Tam

The interplay between angular momentum and particle number (which is the equivalent to the angular momentum in gauge space) is studied. The same technique that is used in the case of rotations in ordinary space can be used in gauge space for investigating the properties of individual quasiparticle levels and the total angular momentum of a nucleus. We study the isotopes of Dy and W, where a back-

The strategic role of communication practitioners has been discussedsince the 1970s. While it might not be surprising that managers andcoworkers view their roles as unclear, it is more surprising that commu-nication practitioners themselves also struggle with explaining theirstrategic roles and the value of their work. To elucidate the strategicwork of communication practitioners, we conducted a s

The Swedish electric vehicle fleet is rapidly growing, creating a need to include their charging demand in future grid planning. Charging stations are often placed based on the needs of the transport system, and the grid connection is considered at a later stage with long lead times. This study proposes selecting charging locations based on grid capacity. Doing this by probabilistic load flow requ

Climate change affects timing of reproduction in many bird species, but few studies have investigated its influence on annual reproductive output. Here, we assess changes in the annual production of young by female breeders in 201 populations of 104 bird species (N = 745,962 clutches) covering all continents between 1970 and 2019. Overall, average offspring production has declined in recent decade

A large gold cluster with the formula Au55[(C6H5)3P]12Cl6, was imaged with a high-resolution transmission electron microscope (HRTEM) and a proposed model was confirmed. Growth of gold crystals of approximately 4.0 nm size could be followed, row by row of atoms, with the use of a low light level TV camera and on-line image processing.

Coating Ti-based implants with bioactive materials promotes joining between the prostheses and the bone as well as increasing long-term implant stability. In the present work, the interface between Ti-6Al-4V and bioactive silicate glass coatings, prepared using a simple enameling technique, is analyzed. High-resolution transmission electron microscopy of the glass/alloy interface shows the formati

Soil is an interface of the lithosphere, biosphere, hydrosphere and atmosphere that provides a habitat for microbial growth. The microbial biomass forms an integral part of the soil. The physiological potential and diversity of the microbial communities in soils are strongly associated with the physicochemical properties of soils. The biotic and abiotic characteristics determine the structure and

For the problem describing steady gravity waves with vorticity on a two-dimensional unidirectional flow of finite depth the following results are obtained. (i) Bounds are found for the free-surface profile and for Bernoulli's constant. (ii) If only one parallel shear flow exists for a given value of Bernoulli's constant, then there are no wave solutions provided the vorticity distribution is subje