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Streptococcus pyogenes is an important human pathogen that causes significant morbidity and mortality worldwide. In order to successfully infect the human host, S. pyogenes is equipped with tools that modulate the human immune defence. The present thesis explores how different streptococcal proteins interfere with innate immunity, adaptive immunity, and blood coagulation. M protein is a surface-b
Popular Abstract in Swedish Denna avhandling är en sammanläggningsavhandling som består av fyra artiklar inom arbetsmarknadsområdet. Den första artikeln behandlar en personalförstärkning till arbetsförmedlingen. Metoden har bestått i att jämföra tre arbetsförmedlingskontor som erhållit stora personalförstärkningar med tre kontor som inte fått någon personalförstärkning alls. Resultaten tyder på atThis thesis results from four research projects. The issues addressed in the projects are different types of labour market information problems. The purpose of the first article is to contribute to a better empirical under- standning of how an increase of staff at the Public Employment Service affects job seekers. In 1987, the Swedish Government decided to grant the Labour Market Administration ex
In this study critical load functions and target load functions of nitrogen and sulphur deposition with respect to acidity and minimum base cation to aluminium ratio were calculated with the SAFE model using three different averaging strategies: (1) averaging based on current forest generation, (2) averaging based on next generation and (3) averaging based on the entire simulation period. From the
Pancreatic islets rich in beta-cells were isolated from non-inbred ob/ob-mice and used for studying various aspects of the function of the plasma membrane. A review is given of the authors' work along the following lines: the role of transmembrane transport or membrane binding in the recognition of insulin-releasing sugars, amino acids, sulfonylureas, and sulphydryl-blocking agents; the role of cy
Background: To understand user needs, system requirements and organizational conditions towards successful design and adoption of Clinical Decision Support Systems for Type 2 Diabetes (T2D) care built on top of computerized risk models. Methods: The holistic and evidence-based CEHRES Roadmap, used to create eHealth solutions through participatory development approach, persuasive design techniques
Three dimensional molecular dynamics (MD) is used to model the mechanical response at the interface between a thin Cu coating resting on a base of Si. The copper coating is subjected to a displacement controlled shear load and the atom movements at the Si-Cu interface are monitored to investigate the effects of crystallographic anisotropy. The two crystals have the same crystallographic orientatio
Peptide self-assembly is a spontaneous process, ubiquitous in nature for the creation of highly ordered and complex biological structures, making it a sought after technique in the development of novel biocompatible materials. The process is also strongly associated with various neurodegenerative diseases in the formation of amyloid plaques in diseases such as Alzheimer’s and Parkinson’s, where f
Combined measurements of Higgs boson production cross sections and branching fractions are presented. The combination is based on the analyses of the Higgs boson decay modes H→γγ, ZZ∗, WW∗, ττ, bb, μμ, searches for decays into invisible final states, and on measurements of off-shell Higgs boson production. Up to 79.8 fb-1 of proton-proton collision data collected at s=13 TeV with the ATLAS detecto
Taking advantage of the storage ring free electron laser beamline at Elettra, we have implemented an experimental setup for the generation of sub-picosecond (ps) coherent optical pulses in the VUV range. The setup is based on the frequency up-conversion of a high-power external signal (provided by a Ti:Sapphire laser) and makes use of a relativistic electron bunch as resonating medium. The produce
Remarkable flight performance is key to the survival of adult Odonata. They integrate varied three-dimensional architectures and kinematics of the wings, unsteady aerodynamics, and sensory feedback control in order to achieve agile flight. Therefore, a diverse range of approaches are necessary to understand their flight strategy comprehensively. Recently, new data have been presented in several ke
Circumplanetary discs (CPDs) form around young gas giants and are thought to be the sites of moon formation as well as an intermediate reservoir of gas that feeds the growth of the gas giant. How the physical properties of such CPDs are affected by the planetary mass and the overall opacity is relatively poorly understood. In order to clarify this, we use the global radiation hydrodynamics code FA
Trabecular bone is viscoelastic under dynamic loading. However, it is unclear how tissue viscoelasticity controls viscoelasticity at the apparent-level. In this study, viscoelasticity of cylindrical human trabecular bone samples (n = 11, male, age 18–78 years) from 11 proximal femurs were characterized using dynamic and stress-relaxation testing at the apparent-level and with creep nanoindentation
The adult adaptive immune system is comprised of a wide spectrum of lymphocyte subsets with distinct antigen receptor repertoire profiles, effector functions, turnover times and anatomical locations, acting in concert to provide optimal host protection and self-regulation. While some lymphocyte populations are replenished by bone marrow hematopoietic stem cells (HSCs) through adulthood, others eme
In this paper we consider random distance graphs motivated by applications in neurobiology. These models can be viewed as examples of inhomogeneous random graphs, notably outside of the so-called rank-1 case. Treating these models in the context of the general theory of inhomogeneous graphs helps us to derive the asymptotics for the size of the largest connected component. In particular, we show t
This paper illustrates a novel method to analyze artificial neural networks so as to gain insight into their internal functionality. To this purpose, we will show analysis results of some feed-forward-error-back-propagation neural networks for image processing. We win describe them in terms of domain-dependent basic functions, which axe, in the case of the digital image processing domain, differen
Atmospheric dispersion represents a relatively overlooked problem in connection with the ultimate quality of ELT images corrected by adaptive optics (AO). The aim of this paper is to evaluate the contribution from atmospheric dispersion to the background level of the point-spread function (PSF). Since proper suppression of this level is important for the prospects for direct exo-planet observation
