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Objectives The aim of this study was to investigate possible associations between androgen concentrations in perimenopausal women and symptoms that may be associated with low androgen concentrations in the blood. Methods All women born in the period 1935-1945 and living in a defined geographic area in Sweden (n=10 766) were invited to a screening program that included physical and laboratory exami
As part of the ongoing effort to improve the Northern Hemisphere radiocarbon (C) calibration curve, this study investigates the period of 856 BC to 626 BC (2805-2575 yr BP) with a total of 403 single-year C measurements. In this age range, IntCal13 was constructed largely from German and Irish oak as well as Californian bristlecone pine C dates, with most samples measured with a 10-yr resolution.
Background: The therapeutic alliance may be a moderating factor of outcome in the Attempted Suicide Short Intervention Program (ASSIP). Aims: This study investigates the two components of the therapeutic alliance, patients' satisfaction with the therapeutic relationship and therapeutic outcome and their associations with suicidal ideation over time. Method: A total of 120 patients (55% female; mea
University start-ups are, in the Organisation for Economic Co-operation and Development (OECD) and European Union (EU) policy setting, viewed as important means to transform scientific advances into innovations, corresponding both to market and societal needs (Mowery & Sampat, 2005; Rider, Hasselberg, & Waluszewski, 2013). The high expectations on the ability to directly transform social a
The insect order Hymenoptera originated during the Permian nearly 300 Mya. Ancestrally herbivorous hymenopteran lineages today make up the paraphyletic suborder 'Symphyta', which encompasses c. 8200 species with very diverse host-plant associations. We use phylogeny-based statistical analyses to explore the drivers of diversity dynamics within the 'Symphyta', with a particular focus on the hypothe
In the drop volume method the surface of the drop enlarges throughout the process of the interfacial tension decay. This surface expansion has been measured for drops of various sizes and shapes, where the interfacial tension depression was caused by different proteins such as lysozyme, β-lactoglobulin, bovine serum albumin, sodium caseinate, whey protein concentrate and soy protein isolate at dif
Bladder cancer tumors expressing human epidermal growth factor receptor 4 (HER4) demonstrate improved patient survival. HER4 isoforms and estrogen receptor alpha (ER-α) can form chaperone complexes causing cell-proliferation. We wanted to explore if HER4 isoforms and ER-α could correlate to poor prognosis in bladder cancers. We developed mRNA assays for HER4 isoforms (JM-a, JM-b, CYT1, and CYT2) a
AIMS: Experiencing an acute myocardial infarction (AMI) is a life-threatening event and use of statins can reduce the probability of recurrence and improve long term survival. However, the effectiveness of statins in the real-world setting may be lower than the reported efficacy in randomized clinical trials. Therefore, we aimed to investigate whether low statin treatment adherence during the year
The purpose of the present study was to analyse if a community-based intervention has led to a decrease in alcohol-related accidents and violence, and whether this was mediated by a reduction in excessive drinking and frequency of distilled spirits consumption. We applied logistic regression analyses on cross-sectional, non-repeated data, which was collected from a questionnaire distributed in cla
Modern society depends on dams for renewable hydropower, water supply, and flood control. As climate change increases the frequency of extreme rainfall and flood events, and as the demand for renewable energy sources continues to grow, ensuring the safety of these critical structures becomes more urgent than ever. One of the most serious hidden threats in embankment dams is internal erosion – a sl
This article examines how Swedish social democratic women used the enactment of universal suffrage in 1919/1921 as an argument to gain support for separate organising. The article also analyses the extent to which the Swedish National Federation of Social Democratic Women, founded in 1920, used direct (personal) and indirect (media) channels for voter communication. Both scarce economic resources
OBJECTIVES: To explore the associations between frailty and reproductive axis hormones (as an important regulatory system) in middle aged and older men. DESIGN: Cross-sectional. SETTING: The European Male Aging Study. PARTICIPANTS: Three thousand two hundred nineteen community-dwelling European men aged 40 to 79. MEASUREMENTS: Interviewer-assisted questionnaires to assess physical activity, health
The aim of this study was to elucidate the impact of porcine pancreatic enzymes (Creon® pancrelipase) in comparison to microbial-derived alpha amylase (MD amylase) on the small intestine wall structure, mucosal glycogen accumulation, and enterocyte turnover. The impact of enzyme supplementation on the small intestine was explored in 18 pigs with surgically induced exocrine pancreatic insufficiency
The aim of the present study was to extend the creatinine-based Lund-Malmö GFR equation for use with rescaled cystatin C (r-LMRCys) and validate it against measured GFR (mGFR) in the EKFC cystatin C cohort of children (n = 2,293) and adults (n = 7,727). Rescaling was obtained by dividing each biomarker by a Q-value, representing the population-specific median biomarker level among healthy individu
BACKGROUND: Haemophilus influenzae community-acquired pneumonia (CAP) is common, and it is equally common to Streptococcus pneumoniae in some settings. The purpose of this study was to provide additional data on patients affected by H. influenzae CAP and their outcomes.METHODS: Streptococcus pneumoniae-caused CAP (111 cases) was compared to CAP with H. influenzae (53 cases). Patients were adults (
Objective: Following the favorable outcomes demonstrated by the Early MiNimally-invasive Removal of IntraCerebral Hemorrhage (ENRICH) trial in supratentorial intracerebral hemorrhage (ICH) patients treated with minimally invasive surgery (MIS), and considering the increasing interest in MIS, we aimed to assess the potential eligibility rate for ICH patients in Sweden. Methods: All patients with sp
TP53 is the most frequently mutated gene in human cancer. This gene shows not only loss-of-function mutations but also recurrent missense mutations with gain-of-function activity. We have studied the primary bone malignancy osteosarcoma, which harbours one of the most rearranged genomes of all cancers. This is odd since it primarily affects children and adolescents who have not lived the long life
