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One of the main contributors in the immune system are T cells. The exact molecular mechanisms behind T cell activation are not yet fully understood but it starts through the contact between the T cell and an infected cell. In order to study such interaction, supported lipid bilayers (SLBs) are used to mimic cell membranes and to reduce its complexity but still retaining the fundamental property of
Osteoporosis is a bone disease that is defined as low bone mineral density (BMD) and results in an increased risk of bone fracture. It is a serious public health problem that causes excess mortality and major economical and social impact. Today there are more than 8.9 million fractures connected to low bone mineral density worldwide. Hip fractures are of particular concern since they are associate
The Lane-Emden equation is a non-linear differential equation governing the equilibrium of polytropic stationary self-gravitating, spherically symmetric star models; $${\frac {1}{\xi ^{2}}}{\frac {d}{d\xi }}\left({\xi ^{2}{\frac {d\theta }{d\xi }}}\right)+\theta ^{n}=0.$$ In the isothermal cases we have the Chandrasekhar equation: $${\frac {1}{\xi ^{2}}}{\frac {d}{d\xi }}\left({\xi ^{2}{\frac {
The article is a response to a lecture held by Sarah Coakley at Lund University 2009. In relation to Coakley's reflections on pain, the article addresses the question whether the Passion story still today, and not only in an ecclesial context, can serve as an incitement to a kind of self-examinating reflection. In other words, is it possible to retrieve through the Passion a narrative framework wh
Background: Radiographers' ability and competence is a matter of vital importance for patients. Nursing care is an integral part of the radiographer's work. The demand for high competence in clinical activities has increased in diagnostic radiology and has had an impact on the development of the profession. Aim: The aim was to describe the radiographer's areas of professional competence in relatio
Placodium umbrinum Breuss is reported as new to northern Europe from the island of Gotland, Sweden. The species is described and depicted, and its ecology at the locality on Gotland is given. A key is given for former members of the genus Catapyrenium growing on soil, mosses or bark in the Nordic countries.
Lipase has been encapsulated in ordered mesoporous materials in a one-step process. The procedure is simple and leads to well structured materials with enzyme loadings higher than those obtained through the post-synthesis approach. In the final bottle-around-the-ship material the enzyme would be entrapped in silica cages whose entrances are smaller than the enzyme itself. Therefore, reagents and p
Many animals use the spectral distribution of light to guide behaviour, but whether they have colour vision has been debated for over a century. Our strong subjective experience of colour and the fact that human vision is the paradigm for colour science inevitably raises the question of how we compare with other species. This article outlines four grades of 'colour vision' that can be related to t
Background: Stroke is a major cause of mortality and morbidity across the world. Air pollution has become an acknowledged risk factor for stroke, especially for acute effects. There is less support for effects by chronic exposure due to the methodological challenges inherent in such studies. Such challenges can regard missing individual level data or residual confounding and can partly be overcome
This paper explores the interaction between brand orientation and market orientation. Brand orientation is an inside-out, identity-driven approach that sees brands as a hub for an organization and its strategy. Similarly, market orientation is an outside-in, image-driven approach. Initially, brand orientation and market orientation appear to be two different strategic options. Though synergistic c
Exposure of metazoan organisms to hypoxia engages a metabolic switch orchestrated by the hypoxia-inducible factor 1 (HIF-1). HIF-1 mediates induction of glycolysis and active repression of mitochondrial respiration that reduces oxygen consumption and inhibits the production of potentially harmful reactive oxygen species (ROS). Here, we show that FoxO3A is activated in hypoxia downstream of HIF-1 a
The aetiology of oral lichen lesions is obscure. In this study the frequency of contact allergy to gold in 83 patients with oral lichen lesions was compared with that in two control groups, comprising 319 age- and gender-matched patients with dermatitis selected from files and 83 clinically examined dermatitis patients. All patients were tested epicutaneously with gold sodium thiosulphate. The two
The global terrestrial carbon cycle plays a pivotal role in regulating the atmospheric composition of greenhouse gases. It has recently been suggested that the upward trend in net primary production (NPP) seen during the 1980's and 90's has been replaced by a negative trend since 2000 induced by severe droughts mainly on the southern hemisphere. Here we compare results from an individual-based glo
Gestational enterovirus (EV) infections have been associated with an increased risk for type 1 diabetes in the offspring. We therefore analyzed non-diabetic mothers for EV exposure in early pregnancy in relation to type 1 diabetes HLA-DQ risk genotypes and seroconversion to islet autoantibodies during pregnancy. Non-diabetic mothers who had islet autoantibodies (n=365) against glutamic acid decarb
Climatic conditions during the winter in countries situated in the north can be considered severe. This is especially true for hydraulic structures, such as hydro power structures, dams, harbours, canals and some bridge foundations. Freezing of concrete in contact with unfrozen fresh water may have a considerable impact on the deterioration process of concrete. This paper presents results obtained
The interactions of biological macromolecules with nanoparticles underlie a wide variety of current and future applications in the fields of biotechnology, medicine and bioremediation. The same interactions are also responsible for mediating potential biohazards of nanomaterials. Some applications require that proteins adsorb to the nanomaterial and that the protein resists or undergoes structural
We have developed a method to estimate free energies of reactions in proteins, called QM/MM-PBSA. It estimates the internal energy of the reactive site by quantum mechanical (QM) calculations, whereas bonded, electrostatic, and van der Waals interactions with the surrounding protein are calculated at the molecular mechanics (MM) level. The electrostatic part of the solvation energy of the reactant
