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A 66-year-old man with type 2 diabetes on hemodialysis treatment was admitted due to poor glycemic control. His serum insulin level and the 125I-insulin binding rate were extremely high with an increased eosinophil count, although he did not have an allergic reaction to insulin or an elevation of specific IgE for human insulin. A Scatchard analysis revealed that the patient’s insulin antibodies ha

Host-defense peptides play a fundamental role in the innate immune system by modulating inflammatory responses. Previously, it was shown that the thrombin derived host-defense peptide GKY25 inhibits LPS-induced responses of monocytes and macrophages in vitro, ex vivo, and in vivo. In this study, the effect of GKY25 on the interaction of monocytes/macrophages with Gram-negative bacteria was explore

This book is written by and for researchers who are still in that part of their careers where they are actively using the eye-tracker as a tool; those who have to deal with the technology, the signals, the filters, the algorithms, the experimental design, the programming of stimulus presentation, instructions to participants, working the varying tools for data analysis, and of course, worrying abo

Software inspections have shown to contribute improved software quality. However, as they are time consuming; sometimes the resources available are not sufficient to inspect all documents. Instead of selecting documents ad hoc, sample-driven inspections (SDI) is proposed as a systematic approach to select which subset of documents to inspect. The selection is based on a pre-inspection, where sampl

Comparative psychology is a strongly interdisciplinary field that shares many of its experimental methods and observational techniques with ethology and developmental psychology. The great variety of theories that comparative psychology evokes to explain behavior generates a wide array of exciting and potentially fruitful accounts, but is also problematic. It increases the risk of error in the for

With the assumed digitalisation happening on the end-user side, progressive systems integrators stress the importance of changing the business concept from being installers to being service and solution providers. However, less is known about the details of this process on the end-user side. Based on an online survey of loss prevention managers it can be stated that security digitalisation and fur

The paper opens by generalizing the concept of 'informing science'. It then introduces some meta-scientific perspectives and a discussion of a metaphor that has considerable explanatory power. Two main schools of metascience are presented and contrasted. The difference between treating invariances in natural sciences and in social and cultural sciences is discussed. The double helix is introduced

The experience acquired over a period of 15 years of diagnostic electron microscopy of fine needle aspirates and surgical specimens constitutes the base for this thesis. Some of the tumors analyzed represent rare soft tissue tumors, and consequently not very often ultrastructurally described. In locations where sarcomas are rare and unexpected, electron microscopy may contribute to a correct tumor

Zabrze is a medium size town of 200 000 inhabitants in the region of Upper Silesia, Poland. The development of the town was originally based on the exploitation of heavy industries. In the past few years Zabrze has, however, moved towards more service and tourism oriented industries. As part of this journey, the city of Zabrze sees the need to improve its existing waste management system. This rep