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The pentasaccharide glycoside corresponding to galactosylgloboside (SSEA-3), β-d-Gal p-(1 → 3)-β-d-Gal pNAc-(1 → 3)-α-d-Gal p-(1 → 4)-β-d-Gal p-(1 → 4)-β-d-Glc p-1-OCH2CH2Si-(CH3)3 (4), was synthesized via glycosylation (87%) of 2-(trimethylsilyl)ethyl 2,3,6-tri-O-benzyl-4-O-[2,3,6-tri-O-benzyl-4-O-(2,4,6-tri-O-benzyl-α-d-galactopyranosyl)-β-d- galactopyranosyl]-β-d-glucopyranoside (2) with the gl
This article contributes guidance on how to approach the development of a course curriculum in general and presents a specific example from medical research education. The purpose of this study is to discuss a model for translating needs assessments of targeted learners into a course curriculum. The model employs established methods for data collection, such as different interview approaches and s
We analyze the determinants of firm-based inventors’ collaborations with universities abroad, comparing them with collaborations with national universities. We propose a micro-founded theoretical framework that introduces the role of personal linkages and global organizational pipelines as drivers of international academic collaborations, and we empirically investigate collaborations with national
Regulatory T cells (T(reg)) are currently being tested in clinical trials as a potential therapy in cell and solid organ transplantation. The immunosuppressive drug rapamycin has been shown to preferentially promote T(reg) expansion. Here, we hypothesized that adjunctive rapamycin therapy might potentiate the ability of ex vivo expanded human T(reg) to inhibit vascular allograft rejection in a hum
BACKGROUND: Exposure to moldy or damp indoor environments is associated with allergic disease in young children, but it is unclear whether the effects persist to adolescence. Our objective was to assess whether exposure to mold or dampness during infancy increases the risk of asthma, rhinitis, or IgE sensitization in children followed from birth to 16 years of age.METHODS: We collected questionnai
Cyanobakterier är urgamla prokaryoter, som finns i en mängd olika livsmiljöer över hela världen. Deras förmåga att utföra fotosyntes (det vill säga att använda solljus, vatten och koldioxid för att producera syre- och kolhydrater) gör dem till viktiga primära producenter, och tillsammans med andra växtplankton utgör de basen för akvatiska näringsvävar.Vid optimala tillväxtförhållandena kan populatCyanobacterial blooms are increasing in occurrence and frequency world-wide, mainly due to eutrophication and increased water temperatures. In freshwater, Microcystis is one of the most common bloom-forming genera, renowned for producing the toxin microcystin which is harmful to humans and other mammals. The ability of Microcystis strains to produce microcystins is largely due to the presence or a
AbstractDead standing trees (DSTs) generally decompose slower than wood in contact with the forest floor. In many regions, DSTs are being created at an increasing rate due to accelerating tree mortality caused by climate change. Therefore, factors determining DST fall are crucial for predicting dead wood turnover time but remain poorly constrained. Here, we conduct a re-analysis of published DST f
As products and supply chains (SCs) evolve, logisticians must revisit their under-standing of postponement. The postponement boundary problem acknowledges that value- adding operations' timing and location in global SCs are critical decisions, impacted by taxes and government regulations in different jurisdictions. However, when combining hardware and software
The base of the world economic pyramid, generally called the base of the pyramid (BoP), consists of four billion people with average daily income of four dollars. Over the past several years, the design and development of products and services for BoP markets has been investigated by several authors from different disciplines. While some authors suggest a systems approach to design and develop pro
In the indoor environment there are a number of materials with potential to act as moisture buffers including both building materials and furnishing materials. For daily moisture variations in the indoor air furniture with upholstery can play an important role as moisture buffers. Material properties and calculation models describing the response to moisture variations in the ambient climate for t
Background: Women are disproportionately affected by migraine, representing up to 75% of all migraine cases. This discrepancy has been proposed to be influenced by differences in hormone levels between the sexes. One such hormone is progesterone. Calcitonin gene-related peptide (CGRP) system is an important factor in migraine pathophysiology and could be influenced by circulating hormones. The pur
Climate change is predicted to cause milder winters and thus exacerbate soil freeze–thaw perturbations in the subarctic, recasting the environmental challenges that soil microorganisms need to endure. Historical exposure to environmental stressors can facilitate the microbial resilience to new cycles of that same stress. However, whether and how such microbial memory or stress legacy can modulate
Clinical axillary lymph node management in early breast cancer has evolved from being merely an aspect of surgical management and now includes the entire multidisciplinary team. The second edition of the “Lucerne Toolbox”, a multidisciplinary consortium of European cancer societies and patient representatives, addresses the challenges of clinical axillary lymph node management, from diagnosis to l
A measurement of observables sensitive to effects of colour reconnection in top-quark pair-production events is presented using 139 fb - 1 of 13 TeV proton–proton collision data collected by the ATLAS detector at the LHC. Events are selected by requiring exactly one isolated electron and one isolated muon with opposite charge and two or three jets, where exactly two jets are required to be b-tagge
This study addresses a challenging problem of predicting mean annual precipitation across arid and semi-arid areas in northern Algeria, utilizing deterministic, geostatistical (GS), and machine learning (ML) models. Through the analysis of data spanning nearly five decades and encompassing 150 monitoring stations, the result of Random Forest showed the highest training performance, with R square v
Introduction: Methylation analysis of the promoter region of tumor-suppressor genes has previously shown high sensitivity for detection of high-grade cervical intraepithelial neoplasia (CIN) and cancer. HPV-testing has a high sensitivity to identify women at risk to develop cancer, and has been implemented in cervical screening programs in several countries. But in most HPV-positive women the infe
