Filtyp
In preclinical studies, p53 loss of function impacts chemotherapy response, but this has not been consistently validated clinically. We trained a TP53-loss phenocopy gene expression signature from pan-cancer clinical samples in the TCGA. In vitro, the TP53-loss phenocopy signature predicted chemotherapy response across cancer types. In a clinical dataset of 3003 breast cancer samples treated with
Aim: We aim to broaden the view and the understanding of what a case competition is and how it can be used beyond its use as an educational method of teaching and learning. More specifically, the purpose is to explore the phenomenon of case competitions as a branding tool from a strategic brand management perspective. Design/Methodology/Approach: A multi-case study approach inspired by Grounded T
In the present study direct microcalorimetry has been employed to measure heat production of blood plasma and blood cells at basal and activated stages. The energetics of granulocyte activation.....
Most off-the-shelf embedded control systems lack proper mechanisms to handle computational overload conditions. Therefore, delays may accumulate and produce overruns, potentially harming the stability and performance of the controlled system. In this paper, we explore a controller implementation in which overrun events are tolerated and tackled with a proper countermeasure, which can be easily plu
The NA62 experiment at CERN reports searches for K+→μ+N and K+→μ+νX decays, where N and X are massive invisible particles, using the 2016–2018 data set. The N particle is assumed to be a heavy neutral lepton, and the results are expressed as upper limits of O(10−8) of the neutrino mixing parameter |Uμ4|2 for N masses in the range 200–384 MeV/c2 and lifetime exceeding 50 ns. The X particle is consi
PoxtA and OptrA are ATP binding cassette (ABC) proteins of the F subtype (ABCF). They confer resistance to oxazolidinone and phenicol antibiotics, such as linezolid and chloramphenicol, which stall translating ribosomes when certain amino acids are present at a defined position in the nascent polypeptide chain. These proteins are often encoded on mobile genetic elements, facilitating their rapid s
Retrospectively, the first 143 patients who were operated on with bilateral internal thoracic arteries (BITA group) were matched with 143 patients operated on with only one left internal thoracic artery anastomosed on the left anterior descending artery and additional vein grafts (LITA group) and followed up for a maximum of 8 years. At 5 years follow-up there were no significant differences in ev
In recent years, the Icelandic dairy product skyr has been transformed from an everyday staple to a national food heritage. Skyr is high in protein and low in fat, and its nutritional value accounts for its international success. However, the domestic and international marketing of skyr glide effortlessly from medieval literature to modern healthy living in promoting skyr as a unique, wholesome, a
PEPCRE is an interactive computer graphics program for the rapid construction, manipulation and display of oligopeptides. Essentially any desired conformation of an oligopeptide can be constructed in a simple and straightforward manner. The program provides various display and output possibilities. It is user-friendly and is written in FORTRAN 77 for use on inexpensive, monochrome graphics termina
Protected area networks help species respond to climate warming. However, the contribution of a site's environmental and conservation-relevant characteristics to these responses is not well understood. We investigated how composition of nonbreeding waterbird communities (97 species) in the European Union Natura 2000 (N2K) network (3018 sites) changed in response to increases in temperature over 25
Businesses are an essential driver for sustainability, yet managers struggle to make decisions about their business model that actually improve their sustainability performance. In this episode, we meet Florian Lüdeke-Freund, Henning Breuer, and Lorenzo Massa, authors of the new book called ‘Sustainable Business Model Design’. They introduce the concept of sustainable business model patterns, to s
We provide an abstract approach to approximation with a wide range of regularity classes X in spaces of pseudocontinuable functions Kp Θ, where Θ is an inner function and p > 0. More precisely, we demonstrate a general principle, attributed to A. Aleksandrov, which asserts that if a certain linear manifold X is dense in Kq Θ for some q > 0, then X is in fact dense in Kp Θ for all p > 0. Moreover,
Using methods from complex analysis we obtain some qualitative results for the kinetic energy of two-dimensional irrotational water flows (monotonicity of horizontal averages with depth, location of the extrema).
In recent decades, the Barents Sea has warmed more than twice as fast as the rest of the Arctic in winter, but the exact causes behind this amplified warming remain unclear. In this study, we quantify the wintertime Barents Sea warming (BSW, for near-surface air temperature) with an average linear trend of 1.74 °C decade-1 and an interdecadal change around 2003 based on a surface energy budget ana
When engaging in international collaboration, researchers and research institutions have to relate to a great range of differences in legislation, scientific practices, incentive systems, and cultural norms. The research landscape has become even more complex in the last decade, and the gray zones at the intersections of a diverse set of institutional contexts may be used to push boundaries. The f
We consider differential Lyapunov and Riccati equations, and generalized versions thereof. Such equations arise in many different areas and are especially important within the field of optimal control. In order to approximate their solution, one may use several different kinds of numerical methods. Of these, splitting schemes are often a very competitive choice. In this article, we investigate the
