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BACKGROUND: Cardiovascular calcification is a significant predictor and contributor to cardiovascular diseases. Vascular smooth muscle cell (SMC)-derived extracellular vesicles (EVs) play a crucial role in microcalcification formation. EVs can originate from the endosomal system, and PIKFYVE (1-phosphatidylinositol 3-phosphate 5-kinase), a lipid kinase, plays a key role in endomembrane maturation.
Introduction: It is well known that urinary tract infection (UTI) during pregnancy is associated with preterm birth, but information about the risk of preterm birth depending on gestational week of infection is sparingly described in the literature. Material and Methods: An observational study based on data from Swedish registers including women giving birth 2014–2020 (n = 684 595). Pregnant women
Objective: To describe longitudinal changes of Magnetic Resonance Imaging (MRI) features in the medial vs lateral tibiofemoral (TF) and patellofemoral (PF) compartments, in knees with no radiographic osteoarthritis (OA) at baseline. Design: In 340 individuals from the Osteoarthritis Initiative aged 45–55 years (51% women) with 430 knees at risk for OA and 250 not at risk, we assessed MRI scans of
Background: Pro-neurotensin (pro-NT) is the stable circulating precursor of neurotensin (NT), a neuropeptide expressed mainly in the central nervous system and small intestine that regulates key physiological processes like fatty acid absorption in the gut and suppresses appetite via central mechanisms. Studies in NT-deficient mice and humans implicate NT in obesity and insulin resistance, highlig
This work investigates the cryogenic performance of InAs-based vertical nanowire ferroelectric field-effect transistors (VNW-FeFETs) with hafnium zirconium oxide (HZO) as the ferroelectric gate dielectric. Measurements at 300 K and 14 K reveal a 25% increase in memory window, from 560 mV at room temperature to 700 mV at 14 K, indicating enhanced polarization stability at low temperatures while als
Hyperbolic phonon polaritons - hybridized modes arising from the ultrastrong coupling of infrared light to strongly anisotropic lattice vibrations in uniaxial or biaxial polar crystals - enable to confine light to the nanoscale with low losses and high directionality. In even lower symmetry materials, such as monoclinic (Formula presented.) -Ga2O3 (bGO), hyperbolic shear polaritons (HShPs) further
Aims: Testing insulin resistance could help improve physician assessment of patients’ risk of prediabetes or type 2 diabetes (T2D), even among normoglycemic individuals. Methods: The longitudinal study followed 16,333 normoglycemic participants in a nation-wide employer-sponsored health assessment program starting in August 2020 with a median follow-up time of 2.9 years for incident prediabetes or
The Swedish music and arts school (SAMS) has been described as “a foundation for Swedish culture, where children and youth are given opportunities to express themselves through dance, fine art, drama, music or other art forms” (Öhrman & Holmdahl, 2022, s. 103). Current debates have questioned SAMS capacity to meet contemporary needs, revolving around themes such as broadening of target groups,
Syftet med denna studie är att analysera hur ungdomar som varit placerade på särskilda ungdomshem upplever, definierar och tolkar ett behandlingsprojekt, som involverade olika myndigheter, benämnt Motverka Våld och Gäng. Dessutom uppmärksammas hur de tolkade de i projektet anställda samordnarna. Den personliga aspekten i relationen mellan ungdomar och samordnare framställs som viktig och det verkThe purpose of this study is to analyse the way young people who were institutionalised in so called special youth-homes experienced, defined and iterpreted on the one hand the project “Motverka Våld och Gäng” (meaning: “Counteract Violence and Gangs”), and on the other hand the Coordinators employed in this project. There is a big variation in the perception of the coordinators. One common deno
Popular Abstract in Swedish See attachment in related materialThe combustion engine is today the dominant technology for transportation of goods and people world-wide. Concerns for global warming, toxic exhaust emissions, as well as cost and availability of fuel have in recent years created incentives for technological evolution of combustion engines. More sophisticated engine instrumentation with additional degrees of freedom has been added to the engine de
Since 2016, the city of Stockholm has been replacing one of the region’s most important communication hubs, the so-called Slussen (The Lock). This enormous building site is situated within the historical city area of Stockholm. For this reason, archaeologists have been involved throughout the process, mapping a giant historic topographic jigsaw puzzle. This paper is a meta-study of the archaeologi
Background: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a heterogenous autoimmune disease. While traditionally stratified into two conditions, granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA), the subclassification of ANCA-associated vasculitis is subject to continued debate. Here we aim to identify phenotypically distinct subgroups and develop a da
Quantum interference (QI) can strongly affect electric and thermoelectric properties of molecular junctions (MJs). So far, however, a limited number of experimental studies have explored the influence of QI on thermoelectric transport in MJs. To address this open point, we synthesized derivatives of meta-OPE3 with an electron-withdrawing nitro (-NO2) substituent or an electron-donating N,N-dimethy
Background: Lifestyle choices, metformin, and dietary supplements may prevent GDM, but the effect of intervention characteristics has not been identified. This review evaluated intervention characteristics to inform the implementation of GDM prevention interventions. Methods: Ovid, MEDLINE/PubMed, and EMBASE databases were searched. The Template for Intervention Description and Replication (TIDieR
Myostatin negatively regulates skeletal muscle size in multiple species, and therefore, myostatin blockade has been therapeutically explored to promote muscle growth in humans, including to counter the muscle loss seen in obese humans using GLP1R agonists. In this study, we present results from a large multi-cohort genetic association analysis, using data from 1.1 million individuals to examine th
Background: Bioresorbable scaffolds have been associated with inferior outcomes compared to contemporary permanent metallic drug-eluting stents (DES) for percutaneous coronary intervention, particularly within the initial years after implantation; however, their long-term performance remains uncertain. This study aimed to evaluate the long-term outcomes of Swedish patients treated with Absorb bior
