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Introduction: There is a need for new therapies that can enhance response rates and broaden the number of cancer indications where immunotherapies provide clinical benefit. CD40 targeting therapies provide an opportunity to meet this need by promoting priming of tumor-specific T cells and reverting the suppressive tumor microenvironment. This is supported by emerging clinical evidence demonstratin
BACKGROUND: Health workers' (HWs') perspectives on the quality of maternal and newborn care (QMNC) are not routinely collected. In this cross-sectional study, we aimed to document HWs' perspectives on QMNC around childbirth in 12 World Health Organization (WHO) European countries.METHODS: HWs involved in maternal/neonatal care for at least one year between March 2020 and March 2023 answered an onl
With the aim to advance the understanding of immune regulation in MCL and to identify targetable T-cell subsets, we set out to combine image analysis and spatial omic technology focused on both early and late differentiation stages of T cells. MCL patient tissue (n = 102) was explored using image analysis and GeoMx spatial omics profiling of 69 proteins and 1812 mRNAs. Tumor cells, T helper (TH) c
Background: Sodium-glucose co-transporter 2 (SGLT2) inhibitors have been shown to reduce rates of heart failure hospitalisations and cardiovascular death in patients with type 2 diabetes and prior cardiovascular disease. We hypothesised that SGLT2 inhibitors could provide cardiovascular benefits in the post-myocardial infarction setting. We aimed to investigate cardiovascular outcomes of SGLT2 inh
This chapter discusses the development of the ne bis in idem principle and assesses whether its judicial interpretation and application in the last years can be said to constitute a revolution for the enforcement of EU competition law. The analysis is divided into pre- and post-DMA litigation, starting from the creation of the principle of ne bis in idem in the interaction between the CJEU and ECt
This paper presents an alternative workflow for thermal comfort prediction. By using the leverage of Data Science & AI in combination with the power of computational design, the proposed methodology exploits the extensive comfort data provided by the ASHRAE Global Thermal Comfort Database II to generate more customised comfort prediction models. These models consider additional, often signific
BACKGROUND: Different adiposity traits may be causally related to hypertension in different ways. By using genetic variants as randomly allocated proxies for studying the effect of modifying adiposity traits, the Mendelian randomization approach can be used to investigate this. METHODS AND RESULTS: In this study, we used 4 different genetic risk scores (GRS; GRS-BMI 565, GRS-WHR 324, GRS-VAT 208,
Purpose: Becoming widowed is a stressful health-threatening event causing major life changes. We explored how widowed people experience becoming widowed and examined if these experiences are quantitatively associated with widowhood. Methods: A multi-methods study using an exploratory sequential mixed-methods approach including a qualitative descriptive study with widowed people from Denmark and a
BACKGROUND: Quinoa (Chenopodium quinoa Willd.) flour and processed traditional Peruvian quinoa breakfast foods were studied to evaluate the effect of extrusion and post-processing on protein properties, morphology and nutritional characteristics (amino acids and dietary fibers). RESULTS: The extrusion increased quinoa protein crosslinking and aggregation observed by size exclusion high-performance
Work place design based on traditional ergonomic science has, to a large extent, been delimited by information collected from studies of individual human beings. This research approach has not been proven to influence industry shop floor work to an extent corresponding to what could be expected from research efforts (Winkel and Westgaard, 1995). Thus the practitioners are left to decide about the
This thesis, which is based on five original papers, covers different aspects of antibody specificity and diversity, with the overall goal to understand the makeup of antibody repertoires and their functionality as they occur in vivo or as they are developed in the laboratory. Besides their importance in the adaptive immune response, antibodies have emerged as an invaluable tool in applications r
A new topic that during the last years has come to the attention of researchers is supply chain security. Stakeholders are progressively realizing the importance to join the authority regulations issued by governments (e.g. AEO) to reduce transport delays at Customs or other business certifications (e.g. TAPA) to reduce theft or counterfeiting. However the differences and impacts of security certi
Popular Abstract in Swedish Kan immunförsvaret orsaka ledsjukdomar? Ett väl fungerande immunsystem är en förutsättning för att kroppen ska kunna bekämpa diverse sjukdomar orsakade av t. ex. virus och bakterier. En grundläggande egenskap hos immunsystemet är dess förmåga att kunna skilja på vad som är kroppens egna celler och molekyler och vad som är främmande. Man tror att vissa sjukdomar, så kalCollagen-induced arthritis (CIA) is a mouse model for rheumatoid arthritis, in which autoimmunity is induced by immunization with type II collagen (CII), a cartilage-specific protein. In the present work, alpha/beta T cells were shown to be required for CIA and for the production of anti-CII IgG antibodies, whereas gamma/delta T cells were neither necessary nor sufficient for development of CIA. A
The growth of social science and sociology during modernity has always been characterized by a will to create predictability for human actions, under the modern conditions of liberty seen as contingent, unpredictable and unstable. To gain systematic knowledge became a way to solve, counteract or radicalize tensions in society, and thus outweighing the risks of contingency. Furthermore, this develo
The paper discusses the modern metropolis as modernity in nucleo. Thereby it refers to notions like state of emergency, provisional realities, crisis, contingency, complexity. Recurrent references include Simmel, Blumenberg, Musil, Park.
