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Patients with haemophilia A (and their physicians) may be reluctant to switch factor VIII (FVIII) concentrates, often due to concerns about increasing the risk of inhibitors; this reluctance to switch may contribute to patients missing the clinical benefits provided by the arrival of new factor VIII products. This topic was explored at the Eleventh Zurich Haemophilia Forum. Clinical scenarios for
In recent decades, comprehensive rationalisations have been implemented in public dentistry in Sweden. How rationalisations affect working conditions, health and production from a long-term perspective has been poorly investigated. This study aims to analyse changes and associations in dentists' working conditions, health and productivity during a 5-year period. In 2003 and 2008, 65 dentists respo
This study explores the influence of long-range intra-protein electrostatic interactions on the conformation of calmodulin in solution. Ensemble Förster resonance energy transfer (FRET) is measured for calmodulin with a fluorophore pair incorporated specifically with a donor at residue 17 and an acceptor at position 117. This construct was generated by a combination of solid phase peptide synthesi
Twenty-one placentae from type I (insulin-dependent) pregnant diabetic patients, treated with continuous subcutaneous insulin infusion (CSII), were studied morphologically. Despite a near-optimal blood glucose control the placental changes were identical to those previously reported in diabetic pregnancy. The most frequently observed lesion was that of relative placental immaturity; this, when ext
Molecular evolution approaches to developing molecules with characteristics particularly suited for specific applications have become important tools in biomedicine and biotechnology. Not only is it possible to identify molecules with specificities that cannot easily be obtained by other means, but it is also possible to fine-tune in an efficient manner the properties for, in principle, any specif
Previous work has shown that amylose (AM) can cross-link hydrophobically modified polymers by inclusion complexation, whereby thermoreversible cold-setting gels are formed. Here we investigate the complexation of AM with different samples of hydrophobically modified ethyl(hydroxyethyl) cellulose (HMEHEC), distinguished by differences in the architecture of the hydrophobes (the hydrophobic side cha
Since emf measurements with amalgam electrodes have been used, in most studies of the stabilities of complexes between soft metal acceptors and halide ions a series of investigations of the kinetics of electrode reactions were accomplished with halide systems of metal ions in the Groups 11 and 12 in aqueous and/or DMSO solutions. The aim was to establish which complexes contribute to the exchange
The present study of Brassica cretica had two objectives. First, we compared estimates of population structure (Q(st)) for seven phenotypic characters with the corresponding measures for allozyme markers (F-st) to evaluate the supposition that genetic drift is a major determinant of the evolutionary history of this species. Secondly, we compared the genetic (co) variance (G) matrices of five popul
All guidelines recommend short-acting inhaled beta 2-adrenoceptor agonists as the first-line drugs in acute asthma attacks and inhaled corticosteroids as the drugs of choice when regular daily treatment is needed. Short-acting inhaled beta 2-adrenoceptor agonists are not effective in reducing nocturnal awakenings because of their short duration of action. In addition there has been an intense deba
Intumescent coatings are increasingly used as a method of passive fire protection on steel constructions. By forming a carbon network and releasing a blowing agent, the thin intumescent film swells 100-fold at elevated temperatures. The highly insulating foam effectively prevents the load bearing steel from reaching its critical temperature at which it looses its mechanical properties and collapse
Females of many songbird species show a preference for mating with males that have larger song repertoires, but the advantages associated with this preference are uncertain. We tested the hypothesis that song complexity can serve as an indicator of male quality because the development of the brain regions underlying song learning and production occurs when young birds typically face nutritional an
No large randomized multicentre trial has evaluated the efficacy of radiofrequency ablation (RFA) vs. anti-arrhythmic drug (AAD) therapy as a first-line treatment of paroxysmal atrial fibrillation (AF). The Medical ANtiarrhythmic Treatment or Radiofrequency Ablation (MANTRA-PAF) trial is a randomized, controlled, parallel group, multicentre study designed to test whether catheter-based RFA is supe
Mating is costly for both male and female insects and should therefore only occur if it is likely to be successful. Within one scotophase, which is the dark period of the light cycle, male moths can only produce one single spermatophore, which is transferred to the female during mating. Remating within the same scotophase would thus be unsuccessful. We tested the hypothesis that newly mated males
Computer simulations were used to study the effect of a single reinforcement fiber added to a mechanical fibre network. The stresses of the surrounding fibers and inter-fiber bonds increased proportionally to the logarithm of the elastic stiffness of the reinforcement fibre. In the case of fiber failure the breaking stress of the model system increased only little and breaking strain decreased lit
Background: Cystic Fibrosis is a pleiotropic disease in humans with primary morbidity and mortality associated with a lung disease phenotype. However, knockout in the mouse of cftr, the gene whose mutant alleles are responsible for cystic fibrosis, has previously failed to produce a readily, quantifiable lung phenotype. Results: Using measurements of pulmonary mechanics, a definitive lung phenotyp
The measurement of ATP as an estimate of microbial biomass C in humus was studied. Three different acid extractants, H2SO4, TCA and H3PO4 were compared, as well as two different buffers, Tris and arsenate. No difference in extraction efficiency was found when the light output was converted to ATP content using internal ATP standards, but the different extraction agents and buffers influenced the l
A systematic review of radiation therapy trials in several tumour types was performed by The Swedish Council of Technology Assessment in Health Care (SBU). The procedures for evaluation of the scientific literature are described separately (Acta Oncol 2003; 42: 357-365). This synthesis of the literature on radiation therapy for skeletal metastases is based on data from 16 randomized trials. Moreov
Control of orthograde posture and use of adaptive adjustments constitutes essential topics of human movement control, both in maintenance of static posture and in ensuring body stability during locomotion. The objective was to investigate, in twelve normal subjects, how head, shoulder, hip and knee movements and torques induced towards the support surface were affected by vibratory proprioceptive
Popular Abstract in Swedish Jag har huvudsakligen studerat läderbaggen Osmoderma eremita, en ca tre cm lång skalbagge som lever inne ihåliga träd. Larverna av denna s k bladhorning lever av den döda veden på stammens insida i levande ihåliga lövträd (i Sverige främst ek) och av mulmen inne i trädet (den mjölliknande blandning av nedbruten ved, vedsvampar, löv, gamla fågelbon, fladdermöss, insekterThis thesis starts with a review of different biodiversity assessment methods in forests and the rest deals with the metapopulation ecology of Osmoderma eremita, a threatened beetle living in hollow trees. I concentrate on the effect of dispersal, habitat quality and habitat history for the presence, population size and future survival of this species. Dispersal was studied by using both capture-m
