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Background: Nigeria is a major contributor to the global malaria burden. The genetic diversity of malaria parasite populations as well as antibody responses of individuals in affected areas against antigens of the parasite can reveal the transmission intensity, a key information required to control the disease. This work was carried out to determine the allelic frequency of highly polymorphic Plas

Complement C2 deficiency (C2D) is associated with immunological diseases and increased susceptibility to invasive infections caused by encapsulated bacteria such as Neisseria menigitidis. In this study we evaluate the immunogenicity of vaccination against N. menigitidis in C2D. C2D patients (n=22) and controls (n=52) were given a tetravalent meningococcal polysaccharide vaccine. Serum bactericidal

Small synthetic ligands for protein purification have become increasingly interesting with the growing need for cheap chromatographic materials for protein purification and especially for the purification of monoclonal antibodies (mAbs). Today, Protein A-based chromatographic resins are the most commonly used capture step in mAb down stream processing; however, the use of Protein A chromatography

Objective. Antileukoproteinase (ALP) is a physiologic inhibitor of granulocytic serine proteases. The present study was undertaken to investigate its therapeutic benefit in an antibody-transfer model of erosive polyarthritis and to elucidate its potential to interfere with immune complex-dependent inflammatory pathways. Methods. Arthritis development was induced in male (BALB/c x B10.Q)F-1 mice by

Transplantation of allogeneic embryonic neural tissue is a potential treatment for patients with Parkinson's and Huntington's diseases. The supply of human donor tissue is limited, and alternatives such as the use of animal (e.g., porcine) donor tissue are currently being evaluated. Before porcine grafts can be used clinically, strategies to prevent neural xenograft rejection must be developed. Kn

Antimicrobial peptides (AMPs) are evolutionarily ancient molecules. They are essential innate immune response molecules that protect organisms from invading pathogens. Tissue factor pathway inhibitors (TFPI-1 and TFPI-2) C-terminal derived peptides exert host defense mechanisms against microbes. Studies showed that in human plasma, C-terminal TFPI-1 and -2 derived peptides mediate bacterial killin

The archivist Martin Grass defines personal archives as that they do not have to adapt to guidelines when it comes to the culling or preservation of the material, the submitting of the material to an archive is not done directly after the material is created or collected and that they often concern broader subjects. In this thesis I study the creator of the personal archives and the driving forces

IgA nephropathy (IgAN) and Henoch-Schönlein purpura (HSP) are diseases characterized by IgA deposits in the kidney and/or skin. Both may arise after upper respiratory tract infections, but the pathogenic mechanisms governing these diseases remain unclear. Patients with IgAN (n = 16) and HSP (n = 17) were included in this study aimed at examining whether IgA-binding M proteins of group A streptococ

It has previously been shown that sera from multiparous women have increased levels of anti-idiotypic antibodies specific for anti-HLA molecules. γ-Globulins prepared from these sera may be superior to commercial preparations of intravenous γ-globulin (IVIg) for inhibiting HLA alloimmunization. To test this, F(ab′)2 fragments prepared from either commercial IVIg or from the sera of men or multipar

Hu11B6 is a monoclonal antibody that internalizes in cells expressing androgen receptor (AR)-regulated prostate-specific enzyme human kallikrein-related peptidase 2 (hK2; KLK2). In multiple rodent models, Actinium-225-labeled hu11B6-IgG1 ([225Ac]hu11B6-IgG1) has shown promising treatment efficacy. In the present study, we investigated options to enhance and optimize [225Ac]hu11B6 treatment. First,

Tissue factor pathway inhibitor-2 (TFPI-2) has previously been characterized as an endogenous anticoagulant. TFPI-2 is expressed in the vast majority of cells, mainly secreted into the extracellular matrix. Recently we reported that EDC34, a C-terminal peptide derived from TFPI-2, exerts a broad antimicrobial activity. In the present study, we describe a previously unknown antimicrobial mode of ac

This page provides information about flexitime for technical and administrative staff. Content on this page:The local flexi time agreement for technical and administrative staff (TA staff)Exceptions from flexitimeNormal working hoursFlexible working hoursRegistering working hoursIf your manager asks you to work additional working hours or overtimeWorking hours during business travelAnnual working

https://www.staff.lu.se/employment/working-hours/flexitime-technical-and-administrative-staff-ta-staff - 2026-05-26

Your website in the university-wide web solution is automatically archived twice a year, and a backup is also made every night.Websites are archived twice a yearAll websites in the university-wide web solution in Drupal are automatically archived twice a year. Archiving usually takes place just before New Year and around the end of June or beginning of July. Based on these archives, it is possible

https://www.webbpublicering.lu.se/guides-english/archiving-and-backup - 2026-05-27

This master thesis is commissioned by the company Haldex Brake Products AB based in Landskrona. The company is acting on the road vehicle market. Amongst other products the company produces disc brakes for the heavy road vehicle industry. Disc brakes developed by Haldex, based on the sliding caliper principle, are during certain circumstances experiencing problems with malfunction of the brake due

När föräldrar till barn i vårt samhälle blir oense och inte på egen hand kan lösa frågor om vårdnad, boende och umgänge träder vår rättsliga reglering in för att reda ut den konflikt som råder. Regleringen avseende vårdnad, boende och umgänge finns i 6 kap. FB. När en konflikt mellan föräldrar presenteras för socialnämnden eller tas upp i allmän domstol fyller de civilrättsliga reglerna kring vårdThe regulation concerning custody, residence and access are provided in the Swedish Parental Code Chapter 6. When a conflict between parents is presented before the social welfare committee or the general Court, our civil law regulation fills a controlling function as well as a conflict resolution function. Our social welfare committee or our Courts shall ensure that all decisions concerning cus