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Type 2 diabetes is a growing health problem. 537 million people had diabetes in 2021 and the number is continuously increasing. Our group previously showed that the isoforms of the complement inhibitor CD59, named IRIS-1 and IRIS-2 (Isoforms Rescuing Insulin Secretion 1 and 2) are localized in the cytoplasm of pancreatic ß-cells, where they are needed for insulin secretion. A downregulation in the
