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The ability of protein kinase C and casein kinase 2 substrate in neurons (PACSIN)/syndapin proteins to self-polymerize is crucial for the simultaneous interactions with more than one Src homology 3 domain-binding partner or with lipid membranes. The assembly of this network has profound effects on the neural Wiskott-Aldrich syndrome protein-mediated attachment of the actin polymerization machinery
alpha 1-Antitrypsin (AAT), a major endogenous inhibitor of serine proteases, plays an important role in minimizing proteolytic injury to host tissue at sites of infection and inflammation. There is now increasing evidence that AAT undergoes post-translational modifications to yield by-products With novel biological activity. One Such molecule, the C-terminal fragment of AAT, corresponding to resid
Papers from a conference in Lund, Sweden. The title of the conference was "What's new in the Neolithic". The book brings together the latest research on the Neolithic of northern Europe. In the study of the distant human past, certain events and periods have come to represent decisive passages from one human state to another. From a global perspective, the characteristic feature of the last ten t
In this paper, we introduce two computer simulation models to study molecular exchange between aggregates in a colloidal dispersion. The Brownian motion of the colloidal aggregates is simulated as a random walk with a Gaussian distributed step length. In model I, the exchanging molecules are simulated as discrete particles with the exchange process characterized by desorption, molecular diffusion,
Background. A spectrum of cutaneous human papillomaviruses (HPVs) is detectable in nonmelanoma skin cancers, as well as in healthy skin, but the significance that the presence of these types of HPV DNA has for the pathogenesis of skin cancer remains unclear. Methods. We studied 349 nonimmunosuppressed patients with skin lesions (82 with squamous cell carcinomas, 126 with basal cell carcinomas, 49
The use of performance enhancing drugs, especially anabolic androgenic steroids (AAS) has emerged as a social problem outside competitive sports, linked to substance abuse and crime. The purpose of this article is to analyze the use of doping and attitudes to doping outside the competitive sports context in relation to age, gender, ethnicity, so¬cio-economic status, and branch of sport. The articl
Popular Abstract in Swedish Bröstcancer är den vanligaste maligna sjukdomen hos kvinnor i världen. Årligen insjuknar mer än 7300 kvinnor i Sverige, vilket innebär nästan 30 % av all kvinnlig cancer. Mer än 80 000 kvinnor i Sverige är friska efter att ha blivit behandlade för bröstcancer, och cirka 3000 kvinnor lever med återfall av sjukdomen. Prognosen har förbättrats de senaste decennierna, delvi
Popular Abstract in Swedish Hårdare krav på lägre energianvändning i byggnader samt ökade energipriser har gjort att välisolerade hus har blivit vanligare. Ökad medvetenhet om koldioxidens påverkan på klimat-förändringarna har också ökat intresset för trähus. Tjockare isolering ökar dock risken för höga fukttillstånd och med detta också risken för fuktskador. För att förutse och undvika fuktskadorDue to increased awareness of climate change and higher energy costs, well-insulated buildings have become more common. Furthermore, interest in the use of wood in building to produce more carbon dioxide-efficient buildings has increased. However, thicker thermal insulation in building envelopes increases the risk of high relative humidity levels and the risk of mold-related damage in wood frame b
Background and purpose - Childhood fractures are associated with lower peak bone mass (a determinant of osteoporosis in old age) and higher adult fracture risk. By examining time trends in childhood fracture epidemiology, it may be possible to estimate the vector of fragility fracture risk in the future. Patients and methods - By using official inpatient and outpatient data from the county of Skån
The superfamily of G protein-coupled receptors (GPCR) is the largest gene family in the human genome. GPCR-mediated signaling operates in every human cell, and about 50% of existing clinically useful drugs act through GPCR. Kinins are proinflammatory peptides that are rapidly produced extracellularly following pathological insults and tissue damage. These peptides act through two GPCR subtypes, B1
