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PURPOSE: Currently, radiologic response of brain tumors is assessed according to the Macdonald criteria 10 weeks from the start of therapy. There exists a critical need to identify nonresponding patients early in the course of their therapy for consideration of alternative treatment strategies. Our study assessed the effectiveness of the parametric response map (PRM) imaging biomarker to provide f

Världen är föränderlig. För att kunna överleva måste allt liv kunna anpassa sig till rådande förhållanden. För cellen, livets minsta enhet, sker detta bland annat genom reglering av produktionstakten av proteiner, vilka är de molekyler som utför de flesta grundläggande funktioner. En speciell klass av proteiner utgörs av så kallade transkriptionsfaktorer. Dessa slår av eller på en gens produktion Living organisms can be viewed as complex biological machines. In order to function, they must regulate their internal mechanism to do the right thing, at the right time, and in the right amount. Part of this regulation is encoded in gene regulatory networks. These are built up of genes which produce special proteins (transcription factors, tf) that regulate other tf-producing genes. Thus a networ

Checkpoint blockade therapies that reactivate tumour-associated T cells can induce durable tumour control and result in the long-term survival of patients with advanced cancers1. Current predictive biomarkers for therapy response include high levels of intratumour immunological activity, a high tumour mutational burden and specific characteristics of the gut microbiota2,3. Although the role of T c

The shipping industry is of great importance within the European Union since approximately 90 per cent of the Unions external trade goes by sea. There have been several block exemptions that have enabled, and simplified for liner consortia to cooperate and on the 26th of April 2010 a new exemption will enter into force. This thesis focuses on this new exemption and its aim is to investigate under

Purpose: The purpose of this thesis is to gain knowledge and visualize significant issues that a future leadership of the Øresund Region should take into consideration in order to promote regional development. Context: In 2000 Copenhagen in Denmark and Malmö in Sweden got connected by the 18km long Øresund Bridge. The bridge’s explicit purpose was not only to physically connect Denmark and Sweden

Am I allowed to help? – The care manager’s new dilemma Authors: Thea Nilsson Svegard and Helena Rülf Title: Am I allowed to help? – The care manager’s new dilemma Supervisor: Staffan Blomberg Assessor: Alexandru Panican The aim of this essay was to examine how care managers working with elderly look upon their own role in relation to customer-choice. The customer-choice reform is spreading rapi

Det kan vara problematiskt att hålla förhör och åberopa förhör med barn som bevittnat våld i nära relation. När barnet inte uppnått en viss ålder och mognad så att barnets medgivande till förhör är tillräckligt, ska barnet enligt föräldrabalkens bestämmelser företrädas av, vanligtvis, vårdnadshavaren. Åldersgränsen för när barn uppnått en tillräcklig ålder och mognad så att denne själv kan ta till, can be problematic. When the child doesn´t reach a certain age and maturity so the child's consent to interrogation is sufficient, the child will under föräldrabalkens provisions represented by, usually, the guardian. The age limit for when the children reached a sufficient age and maturity, so they can take advantage of their right appears as a general rule be fifteen years. If the child wi

Den globala uppvärmningen orsakar stigande havsnivåer till följd av avsmältning av landis samt termisk expansion av vattnet. Allvarliga konsekvenser befaras till följd av detta, stora landarealer kan komma att svämmas över vilket bland annat kan bidra till klimatflyktingar. Om havsnivån ökar drastiskt står vi i Sverige inför väldiga utmaningar eftersom stora delar av befolkningen är bosatta längs Global warming is causing rising sea levels due to melting of land ice and thermal expansion of water. This could lead to serious consequences around the world, such as environmental refugees. In case of a radical sea level rise, Sweden faces big challenges because many people live along the coasts. This thesis includes a study on how the Scanian coastal municipalities attack the problem of preven

De flesta aktiebolag i Sverige är fåmansföretag – vilket innebär att de ägs till övervägande del av en eller ett fåtal personer – och för dessa företag gäller särskilda skatterättsliga regler. Bakgrunden till denna särreglering är att det inte föreligger något sant tvåpartsförhållande mellan företaget och dess ägare, vilka utan särreglering därför skulle kunna skaffa sig omotiverade skattemässiga Most limited companies in Sweden are closely held companies – which mean that they are predominantly owned by one or a few persons – and for these companies there are special regulations applicable. The reason for having special regulations is that there does not exist a bilateral relationship between the company and the owner. Hence, without these special regulations the owner could receive unjus

questions: Where are the largest gaps between how HES (Heat Exchanger System) are working today and how they could be working according to lean philosophies? How could these gaps be reduced and what effect will it have to HES and their customers? Deliverables: The project contains a gap analysis which is the foundation to a new suggested work pattern. The new work pattern was implemented, evaluate

This study attempts to receive insights and thus, expand the general understanding of customers‟ perceptions and associations towards store image for grocery store in an emerging Lithuania market. The case study of Rimi Baltic company is taken as an example. Further on, a qualitative strategy is employed in this research. Information is collected by employing photo elicitation method, tw

Finansiella tjänster är undantagna från mervärdesskatt och har varit det sedan långt tillbaka. I samband med skattereformen 1990 diskuterades huruvida den generella skatteplikten som gäller för omsättning av varor och tjänster skulle komma att innefatta även finansiella tjänster. Dessa diskussioner ledde emellertid inte till något mer konkret än ett förslag till en särskild skatt i den finansiellaFinancial services are exempt from VAT and have been that for a long time. When the 1990 Swedish-tax reform took place it was discussed whether the overall tax liability applicable to sales of goods and services would also include financial services. The discussions did not lead to anything more concrete than a proposal for a special tax in the financial sector. Technical difficulties, mainly rela

Research aim and questions: The aim of this research is to investigate the way Radio Free Europe’s Romanian Language Service presented the events of December 1989 in Romania. Since Radio Free Europe/Radio Liberty was one of the most important international broadcasting institutions during the Cold War, it is relevant to see what kind of interpretation was assigned to Romania’s 1989 political and