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The immunoglobulin genes of inbred mouse strains that are commonly used in models of antibody-mediated human diseases are poorly characterized. This compromises data analysis. To infer the immunoglobulin genes of BALB/c mice, we used long-read SMRT sequencing to amplify VDJ-C sequences from F1 (BALB/c x C57BL/6) hybrid animals. Strain variations were identified in the Ighm and Ighg2b genes, and an

BackgroundCarotid artery disease is highly prevalent and a main cause of ischemic stroke and vascular dementia. There is a paucity of information on predictors of serious vascular events. Besides percentage diameter stenosis, international guidelines also recommend the evaluation of qualitative characteristics of carotid artery disease as a guide to treatment, but with no agreement on which qualit

The major histocompatibility complex (MHC) is of central importance to the immune system, and an optimal MHC diversity is believed to maximize pathogen elimination. Birds show substantial variation in MHC diversity, ranging from few genes in most bird orders to very many genes in passerines. Our understanding of the evolutionary trajectories of the MHC in passerines is hampered by lack of data on

Biologically active vitamin B6-derivative pyridoxal 5′-phosphate (PLP) is an essential cofactor in amino acid metabolic pathways. PLP-dependent enzymes catalyze a multitude of chemical reactions but, how reaction diversity of PLP-dependent enzymes is achieved is still not well understood. Such comprehension requires atomic-level structural studies of PLP-dependent enzymes. Neutron diffraction affo

While Raman spectroscopy provides opportunities for simultaneous detection and quantitative analysis of multiple species, it also suffers from certain limitations, such as low signal strength, which often makes it unsuitable for the study of minor species. The present work employs a high-repetition-rate and high-power laser and re-introduces an amplification technique to improve the detection limi

The article argues that in Denmark during the past 150 years, moral elites have been central in settling paradoxes within social policy by developing ‘classifications’ of citizens and sectors: who are deserving of help and what sector (public or third) should provide care. Contrary to widely held beliefs, historically, there is no logical or practical connection between ‘more deserving’ and ‘state

Sharing is considered as one of the key elements in circular economy, as well as away to deliver social impact. According to the New Bauhaus initiative by the EuropeanCommission, new neighbourhoods should be environmentally sustainable, provide anaesthetic experience, and deliver social inclusion. This study explores the emergence of sharing business models in the real estate industry. The aim is

A thin (20–80 cm), patchy layer of silt-rich sediment occurs at the surface throughout Svartedalen, a nature reserve 30 km north of Gothenburg, Sweden. This surface silt mantles a bedrock-dominated, fracture-valley landscape. Using data from grain-size analysis, OSL dating and detrital-zircon U-Pb dating, we argue that the silt is loess sourced from glacial sediment that was eroded from local bedr