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Pathogenic germline TP53 variants predispose to a wide range of early onset cancers, often recognized as the Li-Fraumeni syndrome (LFS). They are also identified in 1% of families with hereditary breast cancer (HrBC) that do not fulfill the criteria for LFS. In this study, we present a total of 24 different TP53 variants identified in 31 Swedish families with LFS or HrBC. Ten of these variants, ni
The paper focuses on skills and competences used in audio description (AD) of a Swedish popular scientific journal. The journal, containing complex images and visualizations, is made accessible for visually impaired audiences by producing an audio version. The task is to create a verbal description to enhance understanding and enjoyment. The interpretative process of meaning-making is uncovered by
The Galactic Archaeology with HERMES (GALAH) survey is a large-scale stellar spectroscopic survey of theMilkyWay, designed to deliver complementary chemical information to a large number of stars covered by the Gaia mission. We present the GALAH second public data release (GALAH DR2) containing 342 682 stars. For these stars, the GALAH collaboration provides stellar parameters and abundances for
Mutations in the androgen receptor gene are considered as incompatible with preservation of fertility and have been suggested as a cause of male infertility. Two adult brothers, referred because of gynecomastia and hormonal levels in serum indicating androgen insensitivity (high sex hormone-binding globulin, and LH levels, despite extremely high testosterone concentration), turned out to be relati
In 66 CE, Marcia Servilia (PIR2 S 606) was summoned before the Senate to answer the accusation that she had paid magicians to conduct rites on her father’s behalf (Tac. Ann. 16.30–3; Dio Cass. 62.26.3; Marshall 1990, 363, case no. 24; Pollard 2014). Servilia and her father, who was accused of maiestas, made pleas before the Senate on each other’s behalf and in Tacitus’ narrative her illegal action
BackgroundDuring recent years FLASH radiotherapy (FLASH-RT) has shown promising results in radiation oncology, with the potential to spare normal tissue while maintaining the antitumor effects. The high speed of the FLASH-RT delivery increases the need for fast and precise motion monitoring to avoid underdosing the target. Surface guided radiotherapy (SGRT) uses surface imaging (SI) to render a 3D
