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The 13-amino acid glycopeptide tx5a (Gla-Cys-Cys-Gla-Asp-Gly-Trp*-Cys-Cys-Thr*-Ala-Ala-Hyp-OH, where Trp* = 6-bromotryptophan and Thr* = Gal-GalNAc-threonine), isolated from Conus textile, causes hyperactivity and spasticity when injected intracerebral ventricularly into mice. It contains nine post-translationally modified residues: four cysteine residues, two gamma-carboxyglutamic acid residues,

Models based on generalized plant physiological theory represent a promising approach for describing vegetation responses to environmental drivers on large scales but must be tested for their ability to reproduce features of real vegetation. We tested the capability of a generalized vegetation model (LPJ-GUESS) to simulate vegetation structural and compositional dynamics under various disturbance

This work deals with different aspects of air movements in building components . The investigation shows to what degree the concept of fluid mechanics can be applied to problems concerning air flows in building Components. The applicable parts of fluid mechanics are presented as thoroughly as possible. Based on this concept, routines are outlined to make it possible to handle complex flow and pres

We showed earlier that over-expression of protein kinase C (PKC) epsilon induces neurite outgrowth. The effect is mediated by a region (PKC epsilon PSC1V3) encompassing the pseudosubstrate, the two C1 domains and part of the V3 region, and is independent of the catalytic activity of the enzyme. In this region, residues immediately N-terminal of the C1b domain are crucial for neurite outgrowth. How

Popular Abstract in Swedish Konstant produktion av blodceller i benmärgen krävs för att bibehålla normal syretransport i blodet, sårläkning och ett effektivt immunförsvar. Bakom denna produktion ligger hematopoetiska blodstamceller som regleras av en komplex interaktion mellan dem och deras omgivning. Varje blodstamcell kan med självförnyande celldelningar, där minst en dottercell bibehåller en stHematopoietic stem cells (HSC) are sufficient and required for life long production of all blood cell lineages. Steady state HSCs are largely quiescent and we demonstrate that the kinetics of HSC cell cycling are slower compared to more committed progenitor cells also during expansion and self-renewal ex vivo and in physiological conditions. Such slow kinetics during cell division might reflect a

Dystroglycan is a receptor for extracellular matrix proteins that plays a crucial role during embryogenesis in addition to adult tissue stabilization. A precursor product of a single gene is post-translationally cleaved to form two different subunits, alpha and beta. The extracellular alpha-dystroglycan is a membrane-associated, highly glycosylated protein that binds to various extracellular matri

Popular Abstract in Swedish I denna avhandling har jag studerat jordlöparnas (Carabidae) dynamik i de intensivt brukade landskapen som återfinns i Skånes slättbygd. Jordlöpare är en artrik familj av rovlevande skalbaggar som är vanligt förekommande i jordbruksmark. De livnär sig på en mängd olika insekter, andra leddjur och blötdjur, som t.ex. skadedjur såsom bladlöss eller kålflugans ägg. För attIn this thesis I have focused on studying dynamics of ground beetle assemblages in intensively managed agricultural landscapes. By definition, the land cover of these landscapes is dominated by annually tilled farmland, comprising a range of different crop types, in the context of the southern Swedish province of Scania mostly winter wheat, spring barley, winter rapeseed, and sugar beets. This bac

This work concerns an experimental study of pressure drop and heat transfer for turbulent flow inside a U-duct with relevance for tip cooling of gas turbine blades. The U-duct models the internal blade cooling flow passages. Both friction factors and convective heat transfer coefficients were measured along the bend (turn) part of the U-duct for three different rib configuration cases, namely (a)