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The 13-amino acid glycopeptide tx5a (Gla-Cys-Cys-Gla-Asp-Gly-Trp*-Cys-Cys-Thr*-Ala-Ala-Hyp-OH, where Trp* = 6-bromotryptophan and Thr* = Gal-GalNAc-threonine), isolated from Conus textile, causes hyperactivity and spasticity when injected intracerebral ventricularly into mice. It contains nine post-translationally modified residues: four cysteine residues, two gamma-carboxyglutamic acid residues,

Hematopoietic stem cells (HSCs) are ultimately responsible for the all mature blood cell production. They can primarily be found in the bone marrow (BM) at a low frequency (~0.02%). Unlike other blood cells, HSCs have a high degree of self-renewal capacity, the process where upon cell division, at least one daughter cell has the same properties as the stem cell it was generated from. In addition,

The immune system is an important part of the physiology of higher organisms. In the immune system antibodies play a key role in neutralizing and clearing potentially lethal threats from the environment. The importance of antibodies in the immune system has made them come to the attention as a tool in chemistry and medicine. This thesis, which is based on four original papers, deal with antibody d

Popular Abstract in Swedish Den forskning som presenteras här bygger på studier av ett antal beståndsdelar i bindväv vars funktioner är i stort sett helt okända. Bindväv finns i många strukturer i människokroppen; brosk, senor, skelett, blodkärlens väggar, hud, stödjevävnad runt olika organ etc. Karakteristiskt för bindväv är att cellerna sitter glest, omgivna av ett heterogent material som kallas

Popular Abstract in Swedish Denna avhandling belyser reformer och åtgärder inom högskolesektorn (policies of higher education) som genomfördes av socialdemokratiska regeringar i Sverige och Tyskland, här speciellt i Nordrhein-Westfalen, från mitten av 1960-talet till och med år 2000. Utgångspunkten för avhandlingen var den omfattande litteraturen om förändringar inom europeiska högskolesystem. Det

The European project Nature-SDIplus has developed data and metadata specifications for three INSPIRE Annex III themes: Habitat and Biotopes, Bio-geographical regions and Species distributions. These serves as a foundation for the thematic groups developing the corresponding INSPIRE specifications. The aim of this study is to test a data harmonization approach to make Swedish environmental geodata

Models based on generalized plant physiological theory represent a promising approach for describing vegetation responses to environmental drivers on large scales but must be tested for their ability to reproduce features of real vegetation. We tested the capability of a generalized vegetation model (LPJ-GUESS) to simulate vegetation structural and compositional dynamics under various disturbance

This work deals with different aspects of air movements in building components . The investigation shows to what degree the concept of fluid mechanics can be applied to problems concerning air flows in building Components. The applicable parts of fluid mechanics are presented as thoroughly as possible. Based on this concept, routines are outlined to make it possible to handle complex flow and pres