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The present study was aimed at identifying genetic variants in susceptibility to childhood acute lymphoblastic leukemia (ALL) through replication and validation of polymorphisms selected from two genome wide association studies. The first part of the study was based on the replication of polymorphisms selected from a previously conducted genome wide scan using 50K DNA-SNP microarrays. 47 selected

Lärares praktiska yrkeskunskaper bjuder motstånd mot förspråkligande. Detta problem föreligger inte minst i lärarutbildningen, där det i verksamhetsförlagda delar kan råda både osäkerhet och skilda uppfattningar om vad studenterna behöver göra eller prestera för att uppnå de mål som (bokstavligen) föreskrivits dem. Syftet med avhandlingen har varit att beskriva och förstå villkor och förutsättning

Disasters are the result of a vulnerable socioecological system interacting with a hazard. Causal – or the root causes of – vulnerability relates to historical and contemporary social, economic, political, cultural, and biophysical processes and factors, and human and institutional actors that increase the susceptibility of socioecological systems. Indigenous cultures throughout Papua New Guinea s

Despite profound progress made in reducing neonatal mortality, it remains one of the major global health challenges. In 2019, the World Health Organization estimated that 2.4 million neonatal deaths occurred, accounting for over 45 percent of under-5 deaths worldwide. Most of these neonatal mortalities occur in low-and middle-income (LMIC) with East African countries of Kenya, Uganda and Tanzania

BackgroundTreatment following traumatic knee injury includes neuromuscular training, with or without surgical reconstruction. The aim of rehabilitation is to restore muscle function and address psychological factors to allow a return to activity. Attention is often on rehabilitation of knee function, but deficiencies often persist. Specific interventions addressing psychological factors are sparin

Based on trend, cross-cutting relationships and U-Pb dating, Precambrian mafic dykes in the Singhbhum craton, earlier collectively identified as ‘Newer Dolerite Swarm’ have been separated into seven distinct swarms, which are thought to be the plumbing systems for Large Igneous Provinces (LIPs). These Singhbhum swarms range in age from ∼2.80 Ga to ∼1.76 Ga, and include the ∼2.80 Ga NE-SW trending

A comprehensive understanding of the emotional mechanisms that motivate the symptoms of pediatric obsessive-compulsive disorder (OCD) is important for models of the etiology and treatment of the disorder. Existing models have emphasized the central role of fear, but recent research has highlighted that OCD may also be underpinned by incompleteness and disgust. However, whether incompleteness is re

Background:For software-intensive organizations, Open Source Software (OSS) may provide a pivotal building block in business models and strategies, product and service offerings, as well as in tool and infrastructure setups. The Requirements Engineering (RE) and development processes of OSS take place inside communities where the focal organization is a stakeholder among many, including competitor

The holotype (KUVP 1301) of Styxosaurus snowii—one of the earliest described elasmosaurid plesiosaurians—consists of a well-preserved cranium, mandible and articulated sequence of anterior–mid-series cervical vertebrae found in the lowermost Campanian strata of the Smoky Hill Chalk Member in the Niobrara Formation of Kansas, USA. This particular specimen has proven important for recent phylogenies

Since the beginning of African decolonisation in the mid-twentieth century, many newly independent countries struggled to embark upon a path of sustained economic growth to raise their populations out of poverty. One of these countries is Tanzania. Surrounded by the Great Lakes on the west and bordering the Indian Ocean to the east, Tanzania is the fifth-most populous country in Africa. It is also

Plastics are widely used in our daily lives and industry. Unfortunaltely, most plastics are produced from non-renewable fossil resources. The transition toward sustainable resources such as various biomass is critically important for the future of plastic industry and the whole society. Polyesters consitute a major class of plastics, which are widely used in textiles, packaging and other applicati

Advances in understanding how cancer cells interact with the immune system allowed the development of immunotherapeutic strategies, harnessing patients’ immune system to fight cancer. Dendritic cell-based vaccines are being explored to reactivate anti-tumor adaptive immunity. Immune checkpoint inhibitors and chimeric antigen receptor T-cells (CAR T) were however the main approaches that catapulted

Avhandlingen består av fyra artiklar som alla kretsar kring hur ett effektivt nyttjande av infrastruktur kan uppnås. Tre av artiklarna berör externaliteter i transportsektorn medan den fjärde artikeln rör bostadsmarknaden och hur en skattereform påverkade äldre småhusägares flyttbeteende. Externaliteter uppstår när de beslut som en person (eller företag) tar har effekter även för andra och detta iAll four papers in the thesis share a common theme: how to achieve an efficient use of infrastructure and the built environment. In the presence of externalities, pricing according to the (short-run) marginal cost is one answer on how this can be achieved and the first two papers estimates parts of the marginal cost of traffic. Paper I examines the effect of road and railway noise on property pric

Background Several pressing issues face municipal planners including increased land use and climate change. Managing these issues requires a balance between different actions to accommodate citizen’s demands of ecosystem services (ES) and development projects. The implementation of ES as a new tool for assessments needs to be contrasted by research considering existing tools such as Environmental