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Introduction: Galectin-3 is a pro-fibrotic β-galactoside binding lectin highly expressed in fibrotic liver and implicated in hepatic fibrosis. Selvigaltin (previously known as GB1211) is a novel orally active galectin-3 small molecule inhibitor that has high affinity for galectin-3 (human KD = 25 nM; rabbit KD = 12 nM) and high oral bioavailability in rabbits and man. In this study the efficacy of

Introduction. Information overload, special competences need in the area of information analysis, demand of business innovation, a struggle in the grant jungle are strong factors that influence the daily work flow for a researcher. Taking these aspects into consideration, we introduce a concept that we have named The State of The Research. Aim. We aim to broaden the researcher’s view in his/her re

Tubes fabricated from dilute Zr-alloys serve as miniature pressure vessels in Pressurized Heavy Water Reactors and are subjected to stress, aqueous corrosion and intense irradiation during service. Hydrogen evolved during the corrosion reaction may enter into the material and precipitate as hydride phase, which acquire platelet shaped morphology in Zr-alloys and are known to embrittle the host mat

The paper will argue that the centre-periphery dynamics of the modernisation of sexuality is more complex and difficult to grasp than is usually shown in queer studies and gay history. Existing historiography on the emerging of a modern gay and lesbian identity has failed to study the links between different sites for the emergence of a gay and lesbian subculture. The contacts between Greenland

Popular Abstract in Swedish När vi äter kolhydrater, fett, protein och andra näringsämnen sker kemiska reaktioner i kroppen som kan liknas vid dom som sker när man eldar en brasa. Vid förbränning reagerar kolhydrater med syre och bildar koldioxid och vatten. Denna förbränning frigör den energi som funnits lagrad i kolhydraterna, i brasan i form av värme, och i kroppens celler omvandlas den till keNADH:quinone oxidoreductase, or complex I, is a large, complex and poorly understood bioenergetic enzyme in the respiratory chain of living organisms. The enzyme has a conserved core structure, comprising fourteen protein subunits: Seven subunits protrude from the membrane and contain a flavin prosthetic group and eight iron-sulfur clusters that guide electrons from the oxidation of NADH towards t

This thesis concerns students’ learning and meaning-making in science. The theoretical framework builds upon Human Constructivism. This perspective underlines the unique interplay that occurs between thinking, feeling, and acting in human meaning-making and also stresses the important role of language in learning proc-esses. The aim of the thesis is to learn more about how individual students deve

Large Eddy Simulations (LES) are carried out targeting an unconfined premixed bluff body burner operated with ethanol, n-heptane, Jet A, and a Sustainable Aviation Fuel (SAF) labeled C1. The purpose is to validate the chosen simulation methodology for these fuels, which have not been simulated in the targeted case before, and to provide new information about how they burn and stabilize. The combus

Introduction: Elevated pulmonary vascular resistance (PVR) is observed in both physiological and pathological states. Pulmonary hypertension (PH) is a condition associated with significant morbidity and mortality in neonates and children and curative pharmacotherapy is lacking in most cases. In utero, a high PVR allows for blood to bypass the lungs through the open ductus arteriosus (DA). Vascular

Most companies and organizations are primarily interested in universities' educational activities and to a lesser extent in universities' research activities. Against this background, it is strange that the research on collaboration between universities and the surrounding society is primarily directed towards research collaboration between universities and companies/organizations and to a lesser

Popular Abstract in Swedish Syftet med denna avhandling är att skapa en bättre förståelse för vilken betydelse institutioner har för innovationsprocesser inom regionala innovationssystem. Den fokuserar särskilt på hur olika typer av institutioner på skilda geografiska nivåer samspelar; hur institutionell påverkan förändras i samband med att innovationsprocesser utvecklas över tid; samt vilka möjli

The majority of the large hydro power plants in Sweden were built 1935 - 1975 and are located in a cold climate in the northern parts of Sweden. Since the power plants were designed for a service life of 50-100 years, some of them are soon to reach their estimated service life and some have already passed it. During a condition assessment to determine the status of the Porsi hydro power plant, con

Functional magnetic resonance imaging (fMRI) is a non-invasive technique used for the investigation of brain function, which has found numerous applications within basic neuroscience. The introduction of fMRI as a clinical tool for presurgical mapping of pertinent cortical regions in patients with tumour or epilepsy has facilitated neurosurgical planning, and most likely reduced the risk of severe

I inkomstskattelagen 24 kap. 10 a–10 f §§ finns regler om begränsningar i avdragsrätten för ränta på vissa skulder. Reglerna syftar till att förhindra att den svenska bolagsskattebasen urholkas, genom att ränteavdrag avseende koncerninterna lån gör det möjligt för företag att välja var deras inkomster ska beskattas. Syftet med uppsatsen är att undersöka hur de centrala bestämmelserna i regelverketIn Chapter 24 Sections 10 a–10 f of the Swedish Income Tax Act, there are rules that limit the deductibility of interest expenses related to certain kinds of debts. The purpose of the rules is to prevent companies from using intra-group loans to choose the jurisdiction where their incomes should be taxed, which could erode the Swedish company income tax base. The aim of this thesis is to investiga

Sammanfattning Modern teknologi har medfört helt nya möjligheter för museum att nå ut till en global marknad. Museum har tagit sig an omfattande digitaliseringsprojekt och lanserar numera sina konstkollektioner online. Digitaliseringen omfattar även konstverk som tillhör public domain, vilket betyder att vem som helst är tillåten att mångfaldiga och sprida verken. Problematik uppstår när museum häSummary Modern technology offer entirely new possibilities for museums to reach out on a global market. Museums have undertaken far-reaching mass digitisation projects of their art collections and have established online collections. The digitisation comprises both copyrighted and public domain works of art. Public domain works of art are free for everyone to distribute and reproduce. Problems ari