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Background: Genetic polymorphisms associated with common aetiologically complex diseases have recently been identified through genome-wide association studies. Direct-to-consumer genetic testing for such polymorphisms, with provision of absolute genetic risk estimates, is marketed by several commercial companies. Polymorphisms associated with atrial fibrillation (AF) have shown relatively large r

We have implemented a self-contained package for DNA microarray analysis in R. The package is named aroma and is formerly known as com.braju.sma. The purpose of the package is to provide end-users with easy access to the latest statistical tools and methods, to provide other statisticians with a structured platform to develop and test new analysis methods, and to make our methods available to an a

The activity of the manganese (Mn) efflux transporter SLC30A10 in the liver and intestines is critical for Mn excretion and preventing Mn toxicity. Homozygous loss-of-function mutations in SLC30A10 are a well-established cause of hereditary Mn toxicity. But, the relationship between more common SLC30A10 polymorphisms, Mn homeostasis, and disease is only recently emerging. In 2021, the first coding

INTRODUCTION: Tourette syndrome (TS) and chronic motor or vocal tic disorder (CTD) are neurodevelopmental disorders associated with functional impairment and reduced quality of life. Behavioral therapy (BT) is an effective treatment, but lack of experienced practitioners makes it hard for patients to receive appropriate help. One approach to bridge the gap between demand and availability is to off

Global warming and its effects on climate are of great concern. Climate change can affect buildings in different ways, i.e. it can change the energy demand or the moisture durability of buildings in the future. In Sweden, most of the last 20 years have been mild and wet compared to the 1961-1990 climate reference period. Future needs and risks of the building sector depend on the future climate wh

Personer som självskadar har historiskt sett inte haft så mycket att säga till om i sina egna vårdprocesser. När de har sökt psykiatrisk vård akut, ofta för att de upplevt akut svåra tankar och impulser att skada sig själva och kanske har planerat göra suicidförsök, har personer som självskadar ofta blivit hemskickade utan hjälp, eller så har de blivit inlagda för långvarig psykiatrisk vård som faPeople who self-harm have historically not had much say in their healthcare processes. When seeking psychiatric emergency care, people who self-harm have frequently been turned away, or admitted for lengthy hospitalisations that may aggravate self-harm. The attitudes of psychiatric clinicians toward people who self-harm are important to healthcare users’ experience of care, affecting quality and a

Introduction The benefits of alveolar recruitment manoeuvres (ARMs) conducted during general anaesthesia (GA) have been a topic of debate. An ARM is an intentional transient increase in trans-pulmonary pressure aimed at reopening non-aerated or poorly aerated alveoli that are subsequently kept open by applying positive end-expiratory pressure (PEEP). However, an inappropriately high positive intra

The complexity of human tibiofemoral joint motion is now better understood with the advancement of new methodologies to measure tibiofemoral kinematics in vivo. Marker clusters anchored to stainless steel bone pins inserted directly into the femur and tibia provide the most sensitive and accurate means for directly measuring skeletal tibiofemoral joint motion. Despite its invasiveness, this techni

Background: The COVID-19 pandemic has necessitated changes in European healthcare systems, with a significant proportion of COVID-19 cases being managed on an outpatient basis in primary healthcare (PHC). To alleviate the burden on healthcare facilities, many European countries developed contact-tracing apps and symptom checkers to identify potential cases. As the pandemic evolved, the European Un

In recent decades, distributed temperature sensing (DTS) has emerged as a robust technology for environmental applications, enabling high-resolution temperature measurements along fibre optic cables (FOCs). The actively heated fibre optic (AHFO) method is employed to monitor soil moisture ((Formula presented.), m3 m−3), wherein the soil temperature subsequent to the application of a heat pulse is