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Proteoglycans (PG) are polyanionic proteins consisting of a core protein substituted with carbohydrate chains, that is, glycosaminoglycans (GAG). The biosynthesis of GAG can be manipulated by simple xylosides carrying hydrophobic aglycons, which can enter the cell and initiate the biosynthesis. While the importance of the aglycon is well investigated, there is far less information on the effect of

This study investigated psychometric properties of an instrument for assessing perceived occupational value, the 26-item OVal-pd. Data from 225 Swedish subjects with and without known mental illness were analysed regarding fit to the Rasch measurement model (partial credit model), differential item functioning (DIF), and functioning of the OVal-pd four-category response scale. The reliability (ind

The human papillomavirus (HPV) life cycle is strictly linked to the differentiation program of the infected mucosal epithelial cell. In the basal and lower levels of the epithelium, early genes coding for pro-mitotic proteins and viral replication factors are expressed, while terminal cell differentiation is required for activation of late gene expression and production of viral particles at the v

Type 1 diabetes involves the specific destruction of the pancreatic islet β-cells, eventually resulting in a complete dependency of exogenous insulin. The clinical onset of diabetes is preceded by the appearance of autoantibodies against β-cell antigens. The human leukocyte antigen (HLA) region is the single most important genetic determinant of Type 1 diabetes susceptibility, yet variability in t

The European Employment Strategy and the Destandardisation of Employment Relations: The German Case (English title) Abstract: ‘Non-standard’ employment reflects a continuum of work and employment situations, ranging from well-paid and secure occupations to precarious employment. The paper first identifies both standardisation and de-standardisation processes of work and employment by building o

PurposeThe purpose of this paper is to establish measurable factors that can be used as early indicators of which neighborhoods are most likely to undergo a process of gentrification in a reasonably near future.Design/methodology/approachUsing 1990 data on key demographic variables for 128 neighborhoods in Stockholm, Sweden a model that allows both for testing of spatial clustering and for spatial

Galectins are carbohydrate-recognizing proteins involved in many different pathological processes, including cancer and immune-related disorders. Inhibitors of galectins have evolved from natural oligosaccharides toward more drug-like truncated galactoside scaffolds that only retain key specific interactions of the galactose scaffolds with the galectin carbohydrate recognition domains. In this con

The complexity of granular (geo-)materials is associated with the mobility and interaction of their constituent particles. Under the effect of loading, these materials exhibit a highly inhomogeneous behaviour, which might vary significantly as the loading develops (i.e. certain grain assemblies take up the load whilst other, neighbouring assemblies fall into states of lower load). To that end, und

Membrane fouling is a constant challenge of membrane processes in separation and purification of organic, biomass originated compounds in food, biorefining and biotechnology industries. It persists due to the complexity and high fouling tendency of the bio-based streams and may result in a decrease of filtration capacity, rejection alteration, reduction of membrane lifetime and increase of operati

Depletion of RBMK-1500 spent nuclear fuel (SNF) with and without an erbium burnable absorber was modelled, and onegroup burn-up dependent cross-section libraries for Origen-ARP were created. Depletion calculations for the generation of crosssection libraries were performed using the SCALE 6.1 code package with the TRITON control module, which employs the NEWT deterministic 2D transport code with t

Poststroke recovery requires multiple repair mechanisms, including vascular remodeling and blood-brain barrier (BBB) restoration. Brain pericytes are essential for BBB repair and angiogenesis after stroke, but they also give rise to scar-forming platelet-derived growth factor receptor β (PDGFR-β)–expressing cells. However, many of the molecular mechanisms underlying this pericyte response after st