Filtyp
The lack of in vitro prostate cancer models that recapitulate the diversity of human prostate cancer has hampered progress in understanding disease pathogenesis and therapy response. Using a 3D organoid system, we report success in long-term culture of prostate cancer from biopsy specimens and circulating tumor cells. The first seven fully characterized organoid lines recapitulate the molecular di
With the shift of focus of the regulatory bodies, from fixed process conditions towards flexible ones based on process understanding, model-based optimization is becoming an important tool for process development within the biopharmaceutical industry. In this paper, a multi-objective optimization study of separation of three insulin variants by reversed-phase chromatography (RPC) is presented. The
In the Western world, lymphedema most commonly occurs following treatment of cancer. Limb reductions have been reported utilizing various conservative therapies including manual lymph and pressure therapy, as well as by microsurgical reconstruction involving lymphovenous shunts and transplantation of lymph vessels or nodes. Failure of these conservative and surgical treatments to provide complete
β-Mannanases catalyze the conversion and modification of β-mannans and may, in addition to hydrolysis, also be capable of transglycosylation which can result in enzymatic synthesis of novel glycoconjugates. Using alcohols as glycosyl acceptors (alcoholysis), β-mannanases can potentially be used to synthesize alkyl glycosides, biodegradable surfactants, from renewable β-mannans. In this paper, we i
In recent years, there has been significant shift from rigid development (RD) toward agile. However, it has also been spotted that agile methodologies are hardly ever followed in their pure form. Hybrid processes as combinations of RD and agile practices emerge. In addition, agile adoption has been reported to result in both benefits and limitations. This exploratory study (a) identifies developme
Glycosaminoglycans (GAGs) are essential polysaccharides in normal physiology and disease. However, understanding of the contribution of specific GAG structures to specific biological functions is limited, largely because of the great structural heterogeneity among GAGs themselves, as well as technical limitations in the structural characterization and chemical synthesis of GAGs. Here we describe a
The angular distributions of Drell-Yan charged lepton pairs in the vicinity of the Z-boson mass peak probe the underlying QCD dynamics of Z-boson production. This paper presents a measurement of the complete set of angular coefficients A0−7 describing these distributions in the Z-boson Collins-Soper frame. The data analysed correspond to 20.3 fb−1 of pp collisions at s=8 TeV, collected by the ATLA
Drying has been used for thousands of years to preserve foods. One of the first methods used was open air sun drying which exposes foods directly to solar radiation and ambient air. This method is still used today around the world but it remains underdeveloped on the small-scale for two main reasons. The first is that it can be unhygienic since the food is easily contaminated by pests, dust or mic
This dissertation is about the view of writing. One of the intentions of the study is to analyse different notions of writing that become manifest in media debates about student writing. Another intention is to analyse conceptions of writing in curricula and course plans for upper secondary school in Sweden from 1970 to 2011. Drawing from theories of critical discourse analysis, the study aimThis dissertation is about the view of writing. One of the intentions of the study is to analyse different notions of writing that become manifest in media debates about student writing. Another intention is to analyse conceptions of writing in curricula and course plans for upper secondary school in Sweden from 1970 to 2011. Drawing from theories of critical discourse analysis, the study aim
Using resonant angle-resolved photoemission spectroscopy and electron band-structure calculations, we explore the electronic structure and properties of Sm atoms at the surface and in the bulk of the antiferromagnet SmRh2Si2. We show that the Sm atoms reveal weak mixed-valent behavior both in the bulk and at the surface. Although trivalent 4f emission strongly dominates, a small divalent 4f signal
The Worldwide LHC Computing Grid (WLCG) is today comprised of a range of different types of resources such as cloud centers, large and small HPC centers, volunteer computing as well as the traditional grid resources. The Nordic Tier 1 (NT1) is a WLCG computing infrastructure distributed over the Nordic countries. The NT1 deploys the Nordugrid ARC-CE, which is non-intrusive and lightweight, origina
Context. The Galactic bulge has a bimodal metallicity distribution function: different kinematic, spatial, and, potentially, age distributions characterize the metal-poor and metal-rich components. Despite this observed dichotomy, which argues for different formation channels for those stars, the distribution of bulge stars in the ff-abundance versus metallicity plane has been found so far to be a
The over-arching aim of the access and benefit-sharing (ABS) of genetic resources is to enable fair distribution of benefits between the users (such as universities and biotech companies) and providers (such as biodiversity rich countries) so as to both open the doors for innovation and create incentives for biodiversity conservation. Access to genetic resources is crucial for research related to
The earless, nose-horned agamid lizard Pseudocophotis sumatrana is only represented by a few specimens in collections worldwide. We discovered a historical publication from 1855 by van der Hoeven where the species was described as Calotes nasicornis before the currently accepted original description by Hubrecht in 1879. In order to uphold nomenclatural stability, we provide proof that Calotes nasi
Background: It is mandatory for staff in Swedish community services for people with intellectual disabilities to report incidents of error or malpractice. Aim: The aim is to study if incident reports contribute to developing quality in services for people with intellectual disabilities who present with challenging behaviours. Method: 159 reports on incidents from group homes and daily activities s
