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Allergic contact dermatitis (ACD) is a common T cell mediated skin disease. Small reactive organic molecules called haptens induce ACD. Haptens are not recognized by themselves, but need to bond to endogenous proteins in the skin, and processed further into complete antigens. Antigen specific T cells then recognize the resulting antigen. Although the haptens are well known, the chemical reactions
Our aim was to describe a large population-based cohort of diffuse large B-cell lymphoma (DLBCL) during the last decade, evaluating possible improvement in survival and to identify subgroups in need of novel treatment strategies. The study population encompassed all patients diagnosed with DLBCL in Sweden from 2000 through 2010. Altogether 5349 patients were identified. There was no increase in in
Functional studies of resident microglia require molecular tools for their genetic manipulation. Here we show that microRNA-9-regulated lentiviral vectors can be used for the targeted genetic modification of resident microglia in the rodent brain. Using transgenic reporter mice, we demonstrate that murine microglia lack microRNA-9 activity, whereas most other cells in the brain express microRNA-9.
Objectives - To describe demographics, injury characteristics and outcome of traumatic brain injury (TBI) in northern Sweden over 10 years. Materials and methods - Data were retrospectively collected on those individuals (n = 332) in Norrbotten, northern Sweden, with a TBI who had been transferred for neurosurgical care from 1992 to 2001. Results - A majority were older men with a mild TBI and an
Abstract in UndeterminedIndividuals with the diagnosis of autism need well-functioning home environment to make progress and achieve an acceptable level of quality of life (QoL). Long-term mapping of the daily life of individual persons with disabilities with the purpose of understanding their living situation is rare. The present study deals with the QoL of an adolescent boy with autism and intel
Excited states of Ga-65 and Ga-67 nuclei were populated through the C-12(Ni-58,alpha p) and C-12(Ni-58,3p) reactions, respectively, and investigated by in-beam gamma-ray spectroscopic methods. The NORDBALL array equipped with a charged particle ball and 11 neutron detectors was used to detect the evaporated particles and gamma rays. The level schemes of Ga-6.5.67 were constructed On the basis of g
The search for a method that utilizes biological information to predict humans' place of origin has occupied scientists for millennia. Over the past four decades, scientists have employed genetic data in an effort to achieve this goal but with limited success. While biogeographical algorithms using next-generation sequencing data have achieved an accuracy of 700 km in Europe, they were inaccurate
Scandinavia holds a prominent position in the field of translation, and Swedish is one of the most translated languages. In this study, we explore the scope of Swedish literature translated into both Greek and Spanish in recent years. There are many similarities between the two countries, especially regarding twentieth century history, and in particular as to their relations to Sweden, but at the
Much attention is given to the consequences of airborne particles on human health and well-being. Wear is one source of airborne particles and contributions in the urban environments from wheel-to-rail contacts and disc brakes cannot be neglected. Traditionally, mechanical wear has been associated with the generation of particles of diameters of some microns. However, the research described has fo
Recent studies document a 30-year decline in various measures of entrepreneurship in the U.S. Using detailed Swedish employer-employee data over the period from 1990 to 2013, we find young firms to be more prominent in the Swedish business sector than in the U.S. business sector. Young Swedish firms, aged five years or less, account for more than half of all firms during this period. We also obser
A model system consisting of pure triolein and palmitic acid and LipozymeTM, an immobilized lipase (E.C. 3.1.1.3.). has been used to determine the effects of various reaction parameters on the reaction rate and the formation of by-products in the interesterification reaction. The goal was to minimize the level of diglycerides and eliminate trisaturated triglycerides at an endpoint chosen so that t
THE DISPLACEMENT rate is given for a mode III crack growing in a steady state under dynamic conditions. The material is assumed to be visco-plastic and high strain rates are considered. A regular perturbation expansion is performed. First-order perturbing strains are, with one exception, square root singular near the crack-tip. For overstress exponents less, or equal to 2, a reasonably large regioTHE DISPLACEMENT rate is given for a mode III crack growing in a steady state under dynamic conditions. The material is assumed to be visco-plastic and high strain rates are considered. A regular perturbation expansion is performed. First-order perturbing strains are, with one exception. square root singular near the crack-tip. For overstress exponents less. or equal to 2, a reasonably large re
Activated transcription factor (TF) farnesoid X receptor (FXR) represses glucagon-like peptide-1 (GLP-1) secretion in enteroendocrine L cells. This, in turn, reduces insulin secretion, which is triggered when β cells bind GLP-1. Preventing FXR activation could boost GLP-1 production and insulin secretion. Yet, FXR's broader role in L cell biology still lacks understanding. Here, we show that FXR i
Background: Bacterial vaginosis (BV) is the most common cause of vaginal discharge. It is caused by an imbalance in the normal vaginal microbiota. Symptoms include an offensive odour. Standard oral or vaginal antimicrobial treatments have high immediate cure rates but almost as high recurrence rates. pHyph, a vaginal pessary, contains glucono-delta-lactone (GDL) and sodium gluconate (NaG) which re
During the last decades, the science of remote sensing of the Earth's surface has produced an enormous amount of data. In parallel, with the increase in computational capacity, several classification methods have been applied to the satellite retrievals. This timely combination allows recovering more accurate knowledge about the land cover maps of past times. Therefore, the main goal of this work
The recently discovered glymphatic system, which supports brain-wide clearance of metabolic waste, has become the subject of intense research within the past few years. Its nomenclature arose due to its functionally analogous nature to the lymphatic system in combination with glial cells that are part of its anatomical boundaries. The influx of cerebrospinal fluid (CSF) from perivascular spaces in
Community energy (CE) and grassroots innovations have been widely studied in recent years, especially in the UK, Germany, and the Netherlands, but very little focus has been placed on Sweden. This paper describes and analyses the development and present state of several types of community energy initiatives in Sweden. The methodology uses interviews, document studies, analysis of previous studies,
An external beam setup has been developed for the determination of elemental concentrations in fine aerosols (aerodynamic particle diameter less than about 2 μm). Carbon, nitrogen and oxygen are determined with particle elastic scattering analysis (PESA) and, simultaneously, elements heavier than silicon with PIXE at a proton energy of 3.58 MeV. Earlier work on aerosols with PESA and most PIXE wor
