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ABSTRACT Radioimmunotherapy (RIT) consists of using monoclonal antibodies (mAbs) recognizing tumor-selective antigens, as carriers of cytotoxic radionuclides to tumor tissue. RIT has been effective in lymphoma but less successful in solid tumors. mAbs slowly diffuse from the vasculature into and through solid tumors, resulting in slow, limited accretion of antibodies. The outcome is a low tumor-to
Today, one of the main economic engines is construction field. A few periods of history showed that in Lithuania, the main goal for the companies were to build fast, cheap dwellings on the empty lots. The capital of Lithuania, Vilnius city is not an exception. City is built ineffectively. Functions, neighbourhoods are far apart from each other and the transportation ineffectiveness leads to the lo
Den 5 februari 2016 införde Danmark den beryktade ”smyckeslagen” som bemyndigar den danska polisen att beslagta asylsökandens och andra utlänningars egendom för att täcka kostnader för deras försörjning, logi och hälsovård. Redan som lagförslag fick regleringen hård kritik och många menade att den kan stå i strid med egendomsskyddet i artikel 1 i tilläggsprotokoll 1 i europakonventionen om de mänsOn the 5th of February 2016, an act entered into force in Denmark that give the Police the right to confiscate asylum seekers’ and other aliens’ property in order to use them to cover costs that the authorities might have for their accommodation, health care and other living-costs. Before the act had formally passed, it was subjected to extensive critique. Some critics pointed out that the new leg
Literature reviews from different countries show that the difference between the calculated and measured energy use of the building, often known as “energy performance gap”, can be as high as 100-200%. Knowing the size of the building energy performance gap, if it exists, along with its underlying causes will enable professionals to make more informed assumptions and produce better predictions. As
This essay explores the refugee’s access to human rights in regard to the case of Hirsi Jamaa and others v. Italy. The status of refugee, official or not, entails certain rights and state obligation, but the correlation between refugee rights and human rights is problematic. The analysis of the case parties’ arguments for and against violation of relevant articles of the European Convention for th
As international cross-border tax planning increasingly tests domestic legal frameworks,Sweden has relied on a patchwork of different provisions to combat treaty abuse. Throughthe dynamic interplay between its domestic anti-avoidance rules and international treatyprovisions, Sweden has occasionally deployed its targeted Specific Anti-Avoidance Rules(SAARs) and even discussed the possibility of app
The persistent Energy Performance Gap (EPG) in buildings poses a major obstacle to achieving predicted energy savings and sustainability targets. This study provides a comprehensive review of EPG root causes and mitigation strategies across the building life cycle, encompassing the design, construction, and operation phases. Technical and soft mitigation measures were synthesized, including smart
Idiopathic pulmonary fibrosis is characterized by the accumulation of fibroblasts/myofibroblasts and aberrant remodeling of the lung parenchyma. However, the sources of fibroblasts in IPF lungs are unclear. Fibrocytes are circulating progenitors of fibroblasts implicated in wound healing and fibrosis. In this study we evaluated evidence for the presence of fibrocytes in the lung of patients with i
We show that a generalization of the DAG-like query-to-communication lifting theorem, when proven using sunflowers over non-binary alphabets, yields lower bounds on the monotone circuit complexity and proof complexity of natural functions and formulas that are better than previously known results obtained using the approximation method. These include an nΩ(k) lower bound for the clique function up
Building occupant behaviour is known to be an important factor that drives building energy use and the associated carbon emissions. A substantial body of work has investigated occupant behaviour and the underlying drivers. Yet it is generally known that some buildings allow only minimal behavioural intervention, such as on/off control of lights. Other buildings allow a much higher degree of interv
The advent of high-throughput single-cell transcriptomic analysis of microglia has revealed different phenotypes that are inherently associated with disease conditions. A common feature of some of these activated phenotypes is the upregulation of galectin-3. Representative examples of these phenotypes include disease-associated microglia (DAM) and white-associated microglia (WAM), whose role(s) in
Aerobic granular sludge (AGS) plants have gained growing interest and application due to their low energy demand, small footprint, and low operational costs. However, the fulfilment of strict discharge limits for nitrogen and phosphorus, vast seasonal temperature variations, and large peaks in influent flows may pose challenges to the implementation of AGS. Moreover, the knowledge about microbial
Neural induction by cell-cell signaling was discovered a century ago by the organizer transplantations of Spemann and Mangold in amphibians. Spemann later found that early dorsal blastopore lips induced heads and late organizers trunk-tail structures. Identifying region-specific organizer signals has been a driving force in the progress of animal biology. Head induction in the absence of trunk is
Sustainable supply chain design can be performed using optimisation strategies for minimising environmental impacts while maximising profit. It is not clear how such strategies influence the resilience of a supply chain – its ability to handle disturbances without compromising its function. This research used the ecosystem network analysis (ENA) to evaluate the resilience during the design of a su
Besides reducing fuel demands and indoor air pollution, pyrolytic cooking stoves produce a by-product (biochar) that can improve soil fertility and serve as a sink for carbon sequestration. Most smallholder farmers in Africa depend on wood for fuel, suffer from exposure to smoke and soils in their cultivated farms are deteriorating. Biochar (bio-charcoal) production has potentials to reduce energy
Dimethyl sulfide (DMS) is the dominant biogenic sulfur compound in the ambient marine atmosphere. Low-volatility acids from DMS oxidation promote the formation and growth of sulfur aerosols and ultimately alter cloud properties and Earth's climate. We studied the OH-initiated oxidation of DMS in the Aarhus University Research on Aerosol (AURA) smog chamber and the marine boundary layer (MBL) with
Adaptive phenotypic plasticity may improve the response of individuals when faced with new environmental conditions. Typically, empirical evidence for plasticity is based on phenotypic reaction norms obtained in reciprocal transplant experiments. In such experiments, individuals from their native environment are transplanted into a different environment, and a number of trait values, potentially i
