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Mutation-bearing peptide ligands from mutated nucleophosmin-1 (NPM1) protein have been empirically found to be presented by HLA class I in acute myeloid leukemia (AML). We hypothesized that HLA genotype may impact allogeneic hematopoietic stem cell transplantation (allo-HCT) outcomes in NPM1-mutated AML owing to differences in antigen presentation. We evaluated the effect of the variable of predic

When two putatively cryptic species meet in nature, hybrid zone analysis can be used to estimate the extent of gene flow between them. Two recently recognized cryptic species of banded newt (genus Ommatotriton) are suspected to meet in parapatry in Anatolia, but a formal hybrid zone analysis has never been conducted. We sample populations throughout the range, with a focus on the supposed contac

Context. Gaia Data Release 3 (Gaia DR3) time series data may contain spurious signals related to the time-dependent scan angle. Aims. We aim to explain the origin of scan-angle-dependent signals and how they can lead to spurious periods, provide statistics to identify them in the data, and suggest how to deal with them in Gaia DR3 data and in future releases. Methods. Using real Gaia (DR3) data al

BACKGROUND: Abiraterone acetate plus prednisone significantly improved radiographic progression-free survival compared with placebo plus prednisone in men with chemotherapy-naive castration-resistant prostate cancer at the interim analyses of the COU-AA-302 trial. Here, we present the prespecified final analysis of the trial, assessing the effect of abiraterone acetate plus prednisone on overall s

Standard interpolation techniques are implicitly based on the assumption that the signal lies on a single homogeneous domain. In contrast, many naturally occurring signals lie on an inhomogeneous domain, such as brain activity associated to different brain tissue. We propose an interpolation method that instead exploits prior information about domain inhomogeneity, characterized by different, pote

Atopic dermatitis (AD) is a common inflammatory skin disease that affects both children and adults, including a large number of adults of reproductive age. Several guidelines for the treatment of AD exist, yet specific recommendations for the treatment of pregnant or lactating women and for adults planning to have a child are often lacking. This position paper from the European Task force on Atopi

Background: Widespread implementation of Alzheimer's disease biomarkers in routine clinical practice requires the establishment of standard operating procedures for pre-analytical handling of cerebrospinal fluid (CSF). Methods: Here, CSF collection and storage protocols were optimized for measurements of β-amyloid (Aβ). We investigated the effects of (1) storage temperature, (2) storage time, (3)

There is increasing evidence that microbial volatile organic compounds (mVOCs) play an important role in interactions between microbes in soils. In this minireview, we zoom in on the possible role of mVOCs in the suppression of plant-pathogenic soil fungi. In particular, we have screened the literature to see what the actual evidence is that mVOCs in soil atmospheres can contribute to pathogen sup

Short-duration extreme rainfall can cause severe impacts in built environments and flood mitigation measures require high-resolution rainfall data to be effective. It is a particular challenge to observe convective storms, which are expected to intensify with climate change. However, rainfall monitoring networks operated by national meteorological and hydrological services generally have limited a

Background Cognitive deficits may be characteristic for only a subgroup of first-episode psychosis (FEP) and the link with clinical and functional outcomes is less profound than previously thought. This study aimed to identify cognitive subgroups in a large sample of FEP using a clustering approach with healthy controls as a reference group, subsequently linking cognitive subgroups to clinical and

As climate change and unsustainable waste practices present major global challenges, effective waste management in developing countries becomes critically important. In South Africa, organic waste constitutes a significant share of general waste and is often landfilled, contributing to methane emissions and serious health risks for the population. In response, the Western Cape province has introdu

Forest plantations play a crucial role in the livelihoods of Rwandan people. They provide valuable wood resources, such as timber and biomass energy. The first plantations created in the colonial period from 1920 to 1948 contained only exotic Eucalyptus species, which is thought to out-perform native species in terms of more rapid wood production. Over time, this resulted in the domination of non-

The ability to manipulate spin states with light forms the basis of spin-based photonics. The development of semiconductors with tunable spin properties will enable devices that use spin for information storage, circular polarized light emission, etc. With the recent reports of a chirality-induced spin selectivity (CISS) effect in electrons, the question arises whether structural chirality provide

Svensk straffrätt intar en särställning genom sin avsaknad av ett formellt tillräknelighetskrav, vilket är en fundamental förutsättning för straffansvar i många jämförbara rättsordningar. Frågan om en gärningspersons bristande mentala kapacitet hanteras i stället primärt inom ramen för den subjektiva skuldprövningen, där medvetenhetskravet vid uppsåtsbedömningen spelar en central roll. Denna uppsaSwedish criminal law is distinctive in that it lacks a formal requirement of accountability, even though such a requirement is considered fundamental to criminal liability in many other legal systems. Instead, when a perpetrator has a reduced mental capacity, this is primarily addressed by examining their subjective guilt. A crucial part of this assessment is the awareness requirement when decidin

The screening of foreign direct investment (FDI) has emerged as one of the most contested points of intersection between the interests of national security and the free movement of capital under Article 63 TFEU. Within this evolving regulatory landscape, the Czech FDI Screening Act introduces a residual cate-gory of investments that, while falling outside the scope of mandatory screening, remain s

Introduction: Falls among hospitalized older adults increase morbidity, prolong hospital stays, and raise healthcare costs. Sensor-based technologies and medical devices are emerging tools for fall prevention, but their clinical effectiveness remains uncertain. This systematic review aimed to assess their effectiveness in reducing inpatient falls, staff workload, and physical restraint use in hosp