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Species-related inhibition of human and rat dihydroorotate dehydrogenase by immunosuppressive isoxazol and cinchoninic acid derivatives

The isoxazol leflunomide (N-(4-trifluoromethylphenyl)-5-methylisoxazol-4-carboxamide) and its active metabolite A77-1726 (N-(4-trifluoromethyl)-phenyl-2-cyano-3-hydroxy-crotonic acidamide) are promising disease-modifying antirheumatic drugs now in clinical trials. The malononitrilamides MNA279 (2-cyano-3-cyclopropyl-3-oxo-(4-cyanophenyl)propionamide) MNA715(N-(4-trifluoromethyl)-phenyl-2-cyano-3-h

Reglering av banker

The subject of this dissertation is the regulation of banks. The enquiry is built around three overreaching research questions:1. What is a bank?2. Why do banks have to be regulated?3. How should banks be regulated? Each of these three questions is dedicated a separate and comprehensive section, each consisting of several chapters. Even though the subject is jurisprudence, the perspective of the

Samhällskunskap för alienerad elit : Observationsstudie av Särskilda läroverket

This thesis is built around an observational study of a class at an elite school. The study follows the class through their upper secondary school education (ages 16-19), focusing on social science lessons. I have used ethnographic methodology to describe and problematize how social science and value-based ambitions of equality conflict with the student role of superiority cultivated at this schoo

Reprogramming primary melanoma cells to dendritic cell fate enhances tumor immunogenicity

Background Direct cell reprogramming is characterized by the use of defined factors to rewire the transcriptional and epigenetic network of one cell-type into one of a different lineage. We have recently identified the transcription factors PU.1, IRF8, and BAFT3 (PIB) as sufficient to induce a type 1 conventional dendritic cell (cDC1) fate in both somatic and cancer cells.1,2 cDC1 is a rare dendri

Sigrid Combüchen's Parsifal – time and memory in a dissoluting Europe. A Narrative analysis in Comparison with Aethiopica by the ancient novelist Heliodorus (300 AD).

A comparison between the narrative technique of the ancient Greek novel, 'The Aethiopica' by Heliodorus, and Sigrid Combüchen´s modern tale 'Parsifal'.

Sigrid Combüchen is a Swedish writer, born in Germany 1943, a european 'war child'. Her tale Parsifal (1998) gives perspective of the perils in European history. She uses a historical, mythical and contemporary narrative in a genuinely

Genetic analyses of multiple myeloma and related plasma cell dyscrasias

Popular Abstract in Swedish Elakartade (maligna) blodsjukdomar uppstår i den blodbildande benmärgen, vilken är innesluten i hålrummen i de skelettdelar som kan sägas täckas av en badmössa och en gammaldags baddräkt. En av de celltyper som bildas i benmärgen är plasmacellen, en vit blodkropp som utgör mindre än 2% av benmärgscellerna och som tillverkar specifika antikroppar vid infektioner. Vid monAcquired genetic changes have proved to be of diagnostic and prognostic importance in different hematologic malignancies as well as in some solid tumor types. However, although multiple myeloma (MM), an incurable disease, and its proceeding stage monoclonal gammopathy of undetermined significance (MGUS) are quite common, little is known about the karyotypic features of these plasma cell dyscrasias

Studiehandledning Med Schema SOAN54 HT24-2

1 Studiehandledning med schema och anvisningar En kurs i fyra block Kursen och därmed litteraturen har delats in i fyra ”block” som alla har betydelse för och används i forskning i socialt arbete. Varje block ägnas tre till fyra veckor. Efter ett inledande block om teori i allmänhet och specifikt i samhällsvetenskap och socialt arbete följer tre block som behandlar samhällsvetenskapliga perspektiv

https://www.soch.lu.se/sites/soch.lu.se/files/2024-06/Studiehandledning%20med%20schema%20SOAN54%20HT24-2.pdf - 2026-05-28

Lunds-universitets-magasin-1-2009

LUM Lunds universitets magasin | Nr 1 | 2009 forskning forever Historisk lycka mest olycka Rektor vill göra LU mer synligt 2 LUM nr 1 | 2009 spegLingar av akadeMin LUM nr 1 | 2009 3 Under sin tid som rektor för Lunds universitet traskade Håkan West- ling många gånger med utländska gäster från Domkyrkan och nord- ost, förbi nästan alla universitetets byggnader, upp till Ideon. Redan då föddes idén

https://www.lu.se/sites/www.lu.se/files/lunds-universitets-magasin-1-2009.pdf - 2026-05-28

No title

Course evaluation Course:Monte Carlo Methods for Statistical Inference:MASM11 Evaluted on LTH: Yes Lecturuier: Magnus Wiktorsson Number of students: 16 Grades: 10 VG, 2 G, 4 U Summary: The students were overall satisfied. Some students had issues regarding the grading of the projects. Comments: The course works in general well. However, next time we should be more clear about what we expect from t

https://www.maths.lu.se/fileadmin/maths/utbildning_education/KU_Monte_Carlo_Methods_for_Statistical_Inference.pdf - 2026-05-25

Åsa Hansson

Associate professor Contact details Email: asa [dot] hansson [at] nek [dot] lu [dot] se Phone: +46 46 222 86 61 Mobile: +46 70 958 48 89Organisation Department of Economics Room number: Alfa1:4023 Service point: 10 WebpageÅsa Hanssons profile in Lund University research portalOther affiliations Researcher Lund Tax Academy Researcher Rights, Regulations, and Society Profile area member LU Profile A

https://www.lusem.lu.se/asa-hansson - 2026-05-27

Richard Walters

Researcher Contact details Email: richard [dot] walters [at] mgeo [dot] lu [dot] seOrganisation Department of Earth and Environmental Sciences (MGeo) Service point: 16 WebpageRichard Walters profile in Lund University research portalOther affiliations Project manager Department of Earth and Environmental Sciences (MGeo) Member of Strategic Research Area BECC: Biodiversity and Ecosystem services in

https://www.cec.lu.se/richard-walters - 2026-05-27

Research Projects

RAMP-UP: Regenerative Medicine and Advanced Therapy Medicinal Products – United for PhD Excellence The RAMP-UP Doctoral Programme offers interdisciplinary PhD projects that address the ATMP value chain from invention to clinical translation, and societal impact. Explore the RAMP-UP doctoral fellowship positions offered in the 1st recruitment call: Projects based at Lund University: P1. Advancing G

https://www.stemcellcenter.lu.se/RAMP-UP/research-projects - 2026-05-27

Spectators’ Experience of Watching Dance without Music: A cognitive semiotic exploration of kinesthetic empathy

Empathy is our ability to experience and understand the mental states of others. In movement perception, and in particular in dance spectatorship, it has been argued that we experience observed movements through our own bodies: kinesthetic empathy. However, it has been unclear what exactly kinesthetic empathy encompasses on an experiential level as dance spectatorship research has been dominated b

Gravity water waves over constant vorticity flows: from laminar flows to touching waves

I denna uppsats studerar vi en matematisk modell av vattenvågor över djupt vatten. I synnerhet studerar vi vågor som färdas med konstant hastighet i en horisontell riktning och är likformiga i den vinkelräta horisontella riktningen. På grund av den matematiska svårigheten med den allmänna modellen är det vanligt att utgå från förenklade versioner av problemet. I denna uppsats, gör vi antaganden omIn a recent paper, Hur and Wheeler proved the existence of periodic steady water waves over an infinitely deep, two-dimensional and constant vorticity flow and subject to gravity whose profile overhangs, among which, waves whose surface touches at a point, enclosing a bubble of air. We take this further, proving the existence of a continuous curve of water waves from a laminar flow up to a touchin

Lifting with colourful sunflowers

We show that a generalization of the DAG-like query-to-communication lifting theorem, when proven using sunflowers over non-binary alphabets, yields lower bounds on the monotone circuit complexity and proof complexity of natural functions and formulas that are better than previously known results obtained using the approximation method. These include an nΩ(k) lower bound for the clique function up

Observational evidence for chemical ozone depletion over the Arctic in winter 1991-92

LONG-TERM depletion of ozone has been observed since the early 1980s in the Antarctic polar vortex, and more recently at mid-latitudes in both hemispheres, with most of the ozone loss occurring in the lower stratosphere1. Insufficient measurements of ozone exist, however, to determine decadal trends in ozone concentration in the Arctic winter. Several studies of ozone concentrations in the Arctic

Perspective on soundscapes : Verb constructions in descriptions of everyday sounds

This study explores how listeners use verb constructions to describeeveryday sounds. It considers (i) how the verb constructions provide Gestaltto events in the form of activities, processes and states, and (ii) how theconstructions correspond to different aspects of a soundscape (soundsources, acoustic properties, and listener reactions). We found that verbconstructions primarily describe sound s

A high-voltage symmetric sodium ion battery using sodium vanadium pyrophosphate with superior power density and long lifespan

Sodium ion batteries have been considered as promising alternatives to lithium ion batteries for large-scale renewable energy and smart grids applications due to their low cost and rich resources. However, critical drawbacks such as low energy density and poor stability are hindering their development and application. In this work, a stable symmetric sodium ion cell using sodium vanadium pyrophosp

Associations between human non-motorised recreational activity on nest box occupation, exploratory behaviour and breeding success in a passerine bird

Anthropomorphic activities have a large impact on ecosystems in many ways, one of which is how animals behave. Non-motorised nature recreation is a popular human activity of which the impacts on nature are largely unknown. These activities, which include hiking, biking, pet walking and horseback riding, tend to increase during the commencement of the breeding activity for most passerine forest bir

Dopaminergic neurons lacking Caspase-3 avoid apoptosis but undergo necrosis after MPTP treatment inducing a Galectin-3-dependent selective microglial phagocytic response

Parkinson’s Disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the Substantia nigra pars compacta (SNpc). Apoptosis is thought to play a critical role in the progression of PD, and thus understanding the effects of antiapoptotic strategies is crucial for developing potential therapies. In this study, we developed a unique genetic model to