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Background: In luminal breast cancer, adjuvant CDK4/6 inhibitors (eg, abemaciclib) improve invasive disease-free survival. In patients with T1–2, grade 1–2 tumours, and one or two sentinel lymph node metastases, completion axillary lymph node dissection (cALND) is the only prognostic tool available that can reveal four or more nodal metastases (pN2–3), which is the only indication for adjuvant abe
Six rotational bands up to energies Ex = 24.7 MeV and spins Jπ=(79/2−) have been identified in 109Sn using the GAMMASPHERE γ-detector array. Four of the bands show smoothly decreasing dynamic moments of inertia at rotational frequencies ℏω > 0.6 MeV. The bands arise at medium spins from a coupling of a valence d5/2, g7/2 or h11/2 neutron to the deformed 2p2h proton excitation of the Z=50 core 108S
Estetik1.pptx RELIGION ANDLIGHET !KONST ESTETISKA VÄRDEN SMAK! Känsloladdade, subjektiva och personliga fenomen Faktorer i social identitet, sammanhållning och exklusion Saknar omedelbar praktisk nytta Involverar upplevelser som är svåra/omöjliga att beskriva ESTETIK RELIGIONS- FILOSOFI PRAKTISK FILOSOFI TEORETISK FILOSOFI Blandade discipliner Grundvalar för trosföreställningar, livshållni
https://www.fil.lu.se/media/utbildning/dokument/kurser/FPRA11/20141/Estetik1.pdf - 2026-07-21
UNLABELLED: Children with congenital and acquired heart disease have an increased risk of thromboembolic events. There is a paucity of evidence on the optimal approach to thromboprophylaxis for this population, and the introduction of direct oral anticoagulants in recent years has led to significant variation in clinical practice. The aim of the study was to describe current practice in thrombopro
Purpose: Although epilepsy has been reported in survivors of childhood cancer outside the central nervous system (CNS), little evidence exists on risk factors for this late complication. Our study aimed to identify risk factors of late-onset epilepsy. Methods: A case-cohort study was conducted within 5-year survivors of non-CNS childhood cancer from the Adult Life after Childhood Cancer in Scandin
Hemispheric asymmetry is a universal property of brain organization with wide implications into brain function and structure, and diseases. This study presents a laterality index for characterizing hemispheric asymmetries that underlie cortical maps using geometric eigenmodes derived from human cortical surfaces. We develop a generalized design to quantify asymmetries across various cortical spati
Objective: To estimate the effect on healthcare resource use after introducing the World Health Organization diagnostic criteria (WHO-2013) for gestational diabetes mellitus (GDM) compared to former criteria in Sweden (SWE-GDM). Design: A cost-analysis alongside the Changing Diagnostic Criteria for Gestational Diabetes (CDC4G) randomised controlled trial. Setting: Sweden, with risk-factor based sc
Zika virus (ZIKV) is a neurotropic flavivirus capable of infecting the adult brain, however its impact on hypothalamic function and metabolic regulation remains unclear. Here, we show that ZIKV invades the hypothalamus of immunocompetent adult mice, where it replicates and persists, leading to sustained insulin resistance. Following infection, ZIKV RNA and negative strand were detected in the hypo
With the aim to understand prolonged and repeated marine anoxia after the Triassic-Jurassic massextinction event, a continuously cored, 338 metre thick succession of Rhaetian to Toarcian sediments was retrieved close to the village of Schandelah near Braunschweig (Lower Saxony, northern Germany). Here, preliminary biostratigraphical, lithological, sedimentological, geochemical, and geophysical bor
ImportanceThe genetic variation in patients with sensorineural hearing loss (SNHL) in the Nordic countries has not been previously reported.ObjectivesThe aim was to describe the genetic variation in a Swedish population and identify factors in favor of a high diagnostic yield.DesignThis was a prospective cohort study. Children with bilateral SNHL and adults with bilateral SNHL and clinically suspe
Background. Treatment of childhood medulloblastoma has evolved to reduce neurotoxicity while improving survival. However, the impact of evolving therapies on late neurocognitive outcomes and adult functional independence remains unknown. Methods. Adult survivors of childhood medulloblastoma (n = 505; median [minimum–maximum] age, 29 [18–46] years) and sibling controls (n = 727; 32 [18–58] years) f
Cardiovascular comorbidity is common in small cell lung cancer (SCLC) and may significantly affect treatment tolerability and patient outcome. Still, there are no established biomarkers for objective and dynamic assessment as a tool for improved treatment decisions. We have investigated circulating levels of midregional-pro-adrenomedullin (MR-proADM), midregional-proatrial-natriuretic peptide (MR-
Retrospectively, the first 143 patients who were operated on with bilateral internal thoracic arteries (BITA group) were matched with 143 patients operated on with only one left internal thoracic artery anastomosed on the left anterior descending artery and additional vein grafts (LITA group) and followed up for a maximum of 8 years. At 5 years follow-up there were no significant differences in ev
The medial temporal lobe (MTL) is connected to the rest of the brain through two main networks: the anterior-temporal (AT) and the posterior-medial (PM) systems. Given the crucial role of the MTL and networks in the physiopathology of Alzheimer's disease (AD), the present study aimed at (1) investigating whether MTL atrophy propagates specifically within the AT and PM networks, and (2) evaluating
Squamous-cell carcinoma of the anus (ASCC) is a rare disease. Barriers have been encountered to conduct clinical and translational research in this setting. Despite this, ASCC has been a prime example of collaboration amongst researchers. We performed a bibliometric analysis of ASCC-related literature of the last 20 years, exploring common patterns in research, tracking collaboration and identifyi
We have identified a first group of 33 new candidates for symbiotic stars (SySt) of the accreting-only variety among the 600 255 stars so far observed by the GALactic Archaeology with HERMES (GALAH) high-resolution spectroscopic survey of the Southern hemisphere, more than doubling the number of those previously known. GALAH aims to high latitudes and this offers the possibility to sound the Galax
PURPOSE: We performed an exploratory analysis of prostate cancer-related pain and fatigue on health-related quality of life in patients with metastatic castration-sensitive prostate cancer receiving apalutamide (240 mg/day) or placebo, with continuous androgen deprivation therapy (ADT), in the phase 3, randomized, double-blind, placebo controlled TITAN trial (NCT02489318). MATERIALS AND METHODS: P
In the last ten years, x-ray free-electron lasers (XFELs) have been successfully employed to characterize metalloproteins at room temperature using various techniques including x-ray diffraction, scattering, and spectroscopy. The approach has been to outrun the radiation damage by using femtosecond (fs) x-ray pulses. An example of an important and damage sensitive active metal center is the Mn4CaO
Health system resilience, known as the ability for health systems to absorb, adapt or transform to maintain essential functions when stressed or shocked, has quickly gained popularity following shocks like COVID-19. The concept is relatively new in health policy and systems research and the existing research remains mostly theoretical. Research to date has viewed resilience as an outcome that can
Aim: To examine international time trends in the incidence of renal replacement therapy (RRT) for end-stage renal disease (ESRD) by primary renal disease (PRD). Methods: Renal registries reporting on patients starting RRT per million population for ESRD by PRD from 2005 to 2014, were identified by internet search and literature review. The average annual percentage change (AAPC) with a 95% confide
