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Electrochemical real-time monitoring of ligand binding to an engineered opioid receptor specific for morphine is reported. In the particular systems studied, 90% of the binding was found to be completed after only 85-120 s. Thus, the binding kinetics has proven to be more rapid than previously believed. The observed association rate constant for the morphine binding reaction was calculated to be 2

Background: Despite improved surgical and oncological treatment, ovarian cancer continues to be the most lethal of the gynecologic malignancies. We aimed to analyze survival trends in epithelial ovarian cancer with regard to age, tumor site, and morphology in Sweden 1960 to 2014. Methods: A nationwide population-based study was conducted using data from the Swedish Cancer Registry on 46,350 women

Popular Abstract in Swedish Lymfom är en grupp tumörsjukdomar som uppkommer från de vita blodkropparna i vårt immunförsvar. Diffust storcelligt B-cellslymfom (DLBCL) är en av de mest aggressiva varianterna av lymfom och uppkommer från den typen av vita blodkroppar som kallas B-celler. Varje år drabbas ca 500 personer i Sverige av DLBCL. Typiska symtom är hastigt tillväxande lymfkörtlar samt viktneDiffuse large B-cell lymphoma (DLBCL) is an aggressive and heterogeneous disease. Identification of prognostic and predictive markers is important to design individualised and effective treatment strategies. This thesis describes different approaches to search for molecular prognostic markers and an attempt to overcome chemotherapy resistance in DLBCL. In the first study it was investigated whet

Nitrogenase is the only enzyme that can cleave the triple bond in N2, making nitrogen avaiable for other organisms. It contains a complicated MoFe7S9C(homocitrate) cluster in its active site. Many computational studies with density-functional theory (DFT) of the nitrogenase enzyme have been presented, but they do not show any consensus-they do not even agree where the first four protons should be

På grund av vissa 3:12-reglers utformning och praxis på området har överlåtelser av fåmansbolag genom den sk. trädabolagsmetoden behandlats skattemässigt olika beroende på om förvärvaren av bolaget ingår i närståendekretsen eller inte. Riksdagen har genom att bifalla Prop. 2018/19:54, avsett att ändra på olikbehandlingen genom att det bl.a. införs ett nytt lagrum i lagstiftningen, 57 kap. 4 a § ILDue to the construction of some 3:12 rules and precedents from the Supreme Administrative Court, transfers of close companies through the so-called ”trädabolagsmetoden” is from a tax aspect treated differently, depending on whether the acquirer of the close company is related to the seller or not. Related persons is currently disfavoured. The Swedish Parliament has through accepting Prop. 2018/19:

Popular Abstract in Swedish Hjärnan är ett komplext system, som är uppbyggd av många olika sorters celler. Alla dessa celler har sitt ursprung i en speciell typ av cell, stamcellen. Neurala stamceller är omogna celler som har förmågan att genom delning både föröka sig själva genom att bilda fler stamceller, och ge upphov till de olika mogna celltyper som finns i hjärnan. Mycket av intresset för deThe molecular specification of neural precursor cells has been suggested to be a progressive process, with a transition from an early requirement for extrinsic signals to intrinsic mechanisms. Thus, the cells in the nervous system acquire distinct fates in response to extrinsic signals, which activate repertoires of transcription factors in a region and cell type specific manner. The studies in th

This thesis deals with the general problem of controlling rigid-body systems through space, with a special focus on unmanned aerial vehicles (UAVs). Several promising UAV control algorithms have been developed over the past decades, enabling truly astounding feats of agility when combined with modern sensing technologies. However, these control algorithms typically come without global stability gu

PURPOSE: The R2Pulm trial was conducted to evaluate the effect of busulfan-melphalan high-dose chemotherapy with autologous stem-cell rescue (BuMel) without whole-lung irradiation (WLI) on event-free survival (main end point) and overall survival, compared with standard chemotherapy with WLI in Ewing sarcoma (ES) presenting with pulmonary and/or pleural metastases. METHODS: From 2000 to 2015, we e

Knowledge of species-environment associations is critical for the management of threatened amphibian populations facing habitat fragmentation and a restricted range. The Coastal Giant Salamander (Dicamptodon tenebrosus) is subject to habitat degradation from logging and human development and is classified as Threatened at its northern range limit in British Columbia, Canada. We examined habitat as

Popular Abstract in English The gene encoding a β-glucosidase originating from the extreme thermophile Thermotoga neopolitana has been cloned and expressed in Escherichia coli. The aim was to produce a thermostable enzyme that could be used to remove sugar residues from glucosylated natural products classified as flavonoids by applying a method combining extraction in hot pressurized water with enThe gene encoding a β-glucosidase originating from the extreme thermophile Thermotoga neopolitana has been cloned and expressed in Escherichia coli. The aim was to produce a thermostable enzyme that could be used to remove sugar residues from glucosylated natural products classified as flavonoids by applying a method combining extraction in hot pressurized water with enzymatic hydrolysis. The β-g

ReachDeckYou can choose to have the content of our webpages or PDF-files read aloud to you by ReachDeck, and save the read pages as MP3 files. ReachDeck also allows you to change the font size, text colour and other settings. ReachDeck is free software that works on smartphones, tablets and laptops. There is no need to download it to your own device first.Click on the link below to enable ReachDec

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Populärvetenskaplig sammanfattning: Mössbauerspektra är en metod som används för att bestämma hur ett mineral, eller molekyl, är uppbyggt. Man undersöker ett visst grundämne, inom geologin undersöker man oftast järn. Efter att ha analyserat ett prov i spektrometern kan man få uppgifter om var och hur järnet sitter i mineralet, eller molekylen. Metoden bygger på att man skickar gammastrålning av eThe Mössbauer effect is used in this work to determine the oxidation and site occupation in biotites that have been treated in different pHs. The work also gives an introduction to the theory behind the Mössbauer effect as well as Mössbauer spectroscopy. It is obvious that the pH has a significant role in the oxidation of the biotites, the more acidic the sample the more it will be oxidised. It is

Abstract in Undetermined Astra- och Microsoft-fallen väntar på avgöranden i Förstainstansrätten. Bägge väcker viktiga principfrågor i skärningspunkten mellan immaterialrätt och konkurrensrätt. Astra1 har fällts av kommissionen för att företaget missbrukat sin dominerande ställning. Med tveksamma och delvis felaktiga uppgifter har Astras ”blockbuster” Losec fått ett förlängt patentskydd. Trots ins

Deep learning has the potential to drastically increase the accuracy and efficiency of prostate cancer diagnosis, which would be of uttermost use. Today the diagnosis is determined manually from H&E stained specimens using a light microscope. In this paper several different approaches based on convolutional neural networks for prostate cancer classification are presented and compared, using th

Abstract Estuaries and salt marshes are important wetlands used by waterbirds during winter and migration. However, many salt-marshes have been transformed into salinas, which currently function as high-tide roosts. Since traditional salt production is no longer profitable, many salinas have been abandoned or converted into aquaculture potentially becoming less attractive to waders. In this study

In this study, we simulated heterotrophic CO2 (Rh) fluxes at six European peatland sites using the ECOSSE model and compared them to estimates of Rh made from eddy covariance (EC) measurements. The sites are spread over four countries with different climates, vegetation and management. Annual Rh from the different sites ranged from 110 to 540 g C m(-2). The maximum annual Rh occurred when the wate

The diversity and community composition of moths (both macro- and micromoths) at 32 sites, representing a wide range of habitat types (forests, grasslands, wetlands, agricultural and urban areas) within a restricted region in central Scania,southern-most Sweden, was investigated by use of light moth traps and compared with vascular plant species richness and habitat characteristics. The results re

Active site titration and activity measurements were performed in hexane on lyophilised lipase preparations containing different amounts of phosphate buffer and lipase immobilised on porous polypropylene. Lyophilisation of Thermomyces lanuginosus lipase with large quantities of phosphate salts (200 mm) increased the specific activity fourfold, and the number of rapidly titratable active sites incr

Three well-known dynamic acidification models (MAGIC, SAFE, SMART) were applied to data sets from five Integrated Monitoring sites in Europe. The calibrated models were used in a policy-oriented framework to predict the long-term soil acidification of these background forest sites, given different scenarios of future deposition of S and N. Emphasis was put on deriving realistic site-specific scena