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Integrin dependent adhesion and dynamic modulations of the actin network are prerequisites for normal cell locomotion. To investigate whether the actin microfilamentous system does play a role in regulation of β2-integrin-induced signalling, we pretreated granulocytes with staurosporine, a well-known protein kinase inhibitor that has also been shown to disrupt the cytoskeleton of intact cells. Pre

Since the seriousness and urgency of climate change has surfaced during the last decade, researchers, experts, and even the pope have argued that dealing with it is a moral issue. However, emissions keep rising and it seems as if few people in the north are ready and willing to make any substantial lifestyle changes to minimize the potentially catastrophic consequences, mainly to the south. Intern

Ions differ in their ability to salt out proteins from solution as expressed in the lyotropic or Hofmeister series of cations and anions. Since its first formulation in 1888, this series has been invoked in a plethora of effects, going beyond the original salting out/salting in idea to include enzyme activities and the crystallization of proteins, as well as to processes not involving proteins lik

Patients with intracranial tumours have an increased risk of venous thromboembolism, particularly during the first month after neurosurgery. A proposed explanation for this increased risk, are procoagulant tumour-derived substances, such as tissue factor, usually measured in peripheral blood. The aim of the present study is to investigate whether a rotational thromboelastometry (ROTEM) can measure

Objective. To investigate the inter- and intra-observer reliability of both qualitative and quantitative parameters used in the assessment of nail-fold capillaroscopy images.Methods. Fifty mosaic nail-fold images of healthy controls (n = 10), patients with primary RP (n = 10) and SSc (n = 30) were assessed in random order by two blinded observers on two occasions at centres in Sweden, UK and The N

Water and salt mass balances for the Dead Sea were modeled to consider different possible methods for maintaining its water level and water volume. In the models, precipitation, evaporation, rivers, ground water, input/output from potash companies and salt production, and brine discharge were included. The mixing time in the Dead Sea was modeled by a 1) single-layer (well-mixed) system, and a 2) t

Within the nuclear Fermi-liquid approach, the memory effect on the Landau-Vlasov-Langevin dynamics is considered. The basic collisional kinetic equation for the Wigner distribution function is reduced to a macroscopic equation of motion for the shape variables of the nucleus. Parametrizing the potential energy of the nucleus at descent from the fission barrier by the inverted oscillator potential,

The aim of the present study was to investigate physiological effects of highly similar production systems with different degrees of automation by use of urinary catecholamines and cortisol as well as salivary cortisol. Furthermore, it was determined whether the physiological response was related to real-time self-reports in terms of feelings of positive and negative arousal, physical exertion, an

Laser thermotherapy is interesting from an immunological point of view since it can reduce tumor volume without causing immunosuppression at the same time as it may induce and/or enhance tumor immunity. In a rat liver tumor model, we have demonstrated that laser thermotherapy 1) is superior to surgical resection, 2) gives a strong rejection immunity associated with an immune cellular response of t

Nutrient availability is of major importance for plant productivity. When estimating long-term sustainability from a nutrient perspective it is therefore interesting to focus on long-term changes in the soil nutrient pools when comparing different forest types. Here, we have highlighted some factors of importance for long term nutrient sustainability (e.g., several forest rotations) and pointed ou

Background: HIV-1 infection is associated with an increased incidence of and mortality from tuberculosis. Few community studies have examined the effect of HIV-2 on tuberculosis. Methods: We investigated the association between HIV-1, HIV-2 and active tuberculosis in four districts (population 42 709) in Bissau, capital of Guinea-Bissau, with the highest known seroprevalence of HIV-2 infection in

Using the resource-based view, we present a set of propositions related to enterprise resource planning (ERP) development, reflections on competitive advantage and the different roles that stakeholders play in the value-chain. This has the goal of building a foundation for future research on ERPs and how stakeholders' desire to achieve competitive advantage influence ERP development, especially wh

Introduction: The role of the exocrine pancreas in regulating gut microflora colonization is unclear. The main objective in the current study was to assess the effect of pancreatic fluid on the growth of pathogenic bacteria and fungi. Methods: The antibacterial activity of pure pig pancreatic juice collected from catheterized, healthy, conscious, and anesthetized pigs was investigated with multir