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In the past years, extracellular vesicles (EVs) have become an important field of research since EVs have been found to play a central role in biological processes. In pathogens, EVs are involved in several events during the host–pathogen interaction, including invasion, immunomodulation, and pathology as well as parasite–parasite communication. In this report, we summarised the role of EVs in inf
We manipulate the information subjects can share on the web concerning socially sensitive actions (public good contribution) and visibility (selfie) to determine the effect on social image, as captured by the price subjects demand for publication. Our novel design incorporates aspects of social media interaction including limited anonymity and the possibility to manipulate published information in
The aim of this work is the development of a thermodynamically consistent fully coupled thermo-viscoplastic material model for metals.The model is based on a split of the free energy into a thermo-elastic, a thermo-plastic and a purely thermal part and covers nonlinear cold-work hardening and thermal softening.Nonlinear temperature dependent effects are accounted for the elastic moduli, the plasti
Steam-diluted combustion in gas turbine systems is an effective approach to control pollutant emissions and improve the gas turbine efficiency. The primary purpose of the present research is to analyze the influence of steam dilution on the combustion stability, flame structures, and CO emissions of a swirl-stabilized gas turbine model combustor under atmospheric pressure conditions. The premixed
e consider waveform iterations for dynamic coupled problems with respect to therole of time window length. We review existing theoretical results about the error of waveformiterations and the role of the time window length. Furthermore, we present numerical resultsfor waveform iterations with both time adaptive sub solvers and with fixed time steps. Thisway, we are able to give a recommendation on
Italian dialects, especially in the south of Italy, have been stigmatised for a long time. Despite more recent revalorization, dialect speakers may still have negative attitudes towards their own variety as a result of internalized prejudices. By comparing Sicilian and Venetan, two of the most spoken dialects in Italy, this study aims to investigate what attitudes dialect speakers have towards the
Background and purpose: Galectin-3 (Gal-3) is a pro-fibrotic β-galactoside binding lectin highly expressed in fibrotic liver and implicated in hepatic fibrosis. GB1107 is a novel orally active Gal-3 small molecule inhibitor that has high affinity for Gal-3 >1000-fold selectively over other galectins. The aim of this study was to characterise GB1107 and galectin-3 in vitro and in vivo in the contex
roduction of biomass for bioenergy on marginal land has been promoted to decrease the use of non-renewable energy without competing with food production. Previous estimates of marginal land and abandoned farmland in Sweden available for bioenergy production are based on general statistics and assumptions but lack in-depth analyses of potential alternative land-use values. Easily accessible public
Objectives: To define requirements that condition trust in artificial intelligence (AI) as clinical decision support in radiology from the perspective of various stakeholders and to explore ways to fulfil these requirements. Methods: Semi-structured interviews were conducted with twenty-five respondents—nineteen directly involved in the development, implementation, or use of AI applications in rad
Purpose: To investigate the impact of reduced injected doses on the quantitative and qualitative assessment of the amyloid PET tracers [18F]flutemetamol and [18F]florbetaben. Methods: Cognitively impaired and unimpaired individuals (N = 250, 36% Aβ-positive) were included and injected with [18F]flutemetamol (N = 175) or [18F]florbetaben (N = 75). PET scans were acquired in list-mode (90–110 min po
The active manipulation of particle and cell trajectories in fluids by high-frequency standing surface acoustic waves (sSAW) allows to separate particles and cells systematically depending on their size and acoustic contrast. However, process technologies and biomedical applications usually operate with non-spherical particles, for which the prediction of acoustic forces is highly challenging and
The management of breast cancer during pregnancy (PrBC) is a relatively rare indication and an area where no or little evidence is available since randomized controlled trials cannot be conducted. In general, advances related to breast cancer (BC) treatment outside pregnancy cannot always be translated to PrBC, because both the interests of the mother and of the unborn should be considered. Eviden
Using Marcus theory, the electric-field-dependent charge-separation dynamics of non-fullerene acceptors D/A heterojunctions are simulated. On the D/A interface, the excited-state characteristics show obvious differences under different electric field intensities, providing microscopic details of the non-fullerene D/A interface at the atomic level. For different electric field conditions, so the ca
A flexible way to generate bimetallic nanoparticles with high control of their composition is to use spark ablation of alloyed electrodes. It has been generally accepted and stated that particles produced using spark ablation of alloyed electrodes obtain the same chemical composition as the electrodes. However, we identify a lack of studies fully supporting the connection between electrode and par
This article explores how the right to respect one’s home under Article 8 of the European Convention on Human Rights would apply in the context of housing and social control. After explaining the connections between social control, housing, and human rights, it analyzes the selected case law of the European Court of Human Rights on Article 8 in certain cases concerning housing with a view to under
Under global warming, flooding has become one of the most destructive natural disasters along the China–Pakistan Economic Corridor (CPEC), which significantly jeopardizes the construction and ongoing stability of the CPEC. The assessment of regional flood potential is, therefore, crucial for effective flood prevention and relief measures. In light of this, our study applied MIKE 11 hydrodynamic mo
Monolayers of soft colloidal particles confined at fluid interfaces are at the core of a broad range of technological processes, from the stabilization of responsive foams and emulsions to advanced lithographic techniques. However, establishing a fundamental relation between their internal architecture, which is controlled during synthesis, and their structural and mechanical properties upon inter
