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Thermodynamic parameters are presented here illustrating the effects caused by the two anticancer active metal complexes cisplatin and oxaliplatin after introduction into four closely related RNA and DNA duplexes. The duplexes used are blunt end, fully complementary 15-mer duplexes with a centrally located either GG- or GNG (here: N = T or U) binding site. For all duplexes, a common trend of reduc
Little is known about prescription trends in atrial fibrillation (AF) in primary health care in Sweden. The aim was to study time trends in pharmacotherapy, in men and women with AF. We also aimed at studying doctors' adherence to CHADS2 for prescribing warfarin. CHADS2 assesses stroke risk by presence of known risk factors, i.e., congestive heart failure, hypertension, age > 75 years, diabetes, p
We present detailed observations of the bright short-hard gamma-ray burst GRB 090510 made with the Gammaray Burst Monitor (GBM) and Large Area Telescope (LAT) on board the Fermi observatory. GRB 090510 is the first burst detected by the LAT that shows strong evidence for a deviation from a Band spectral fitting function during the prompt emission phase. The time-integrated spectrum is fit by the s
Background: In experimental studies, the apolipoprotein D (APOD) and the sigma receptor type 1 (SIGMAR1) have been related to processes of brain damage, repair and plasticity. Methods: We examined blood samples from 3081 ischemic stroke (IS) patients and 1595 control subjects regarding 10 single nucleotide polymorphisms (SNPs) in the APOD (chromosomal location 3q29) and SIGMAR1 (chromosomal locati
Background: There is a great variability in licit prescription drug use in the population and among patients. Factors other than purely medical ones have proven to be of importance for the prescribing of licit drugs. For example, individuals with a high age, female gender and low socioeconomic status are more likely to use licit prescription drugs. However, these results have not been adjusted for
BACKGROUND: There are increasing reports of deaths and serious complications associated with the use of negative pressure wound therapy (NPWT), of which right ventricular heart rupture is the most devastating. The use of a rigid barrier has been suggested to offer protection against this lethal complication by preventing the heart from being drawn up against the sharp edges of the sternum. The aim
Risk communication is recognised as an essential component of crisis preparedness, enabling people at risk to take informed decisions to protect themselves. Research has shown that foreign-born people including refugees and immigrants to a lesser extent than others are reached by the information and are less prepared for crisis, making them particularly vulnerable in crisis situations. Employing a
This article discusses the challenges associated with maintaining water quality, particularly the issue of eutrophication, and the importance of technology advancements for monitoring and managing water quality. The potential of machine learning is highlighted, along with the importance of affordable and effective water quality monitoring techniques. The study aims to identify factors contributing
The main aim of the current study was to explore the association between self-leadership strategies and organisational commitment dimensions whilst focusing on work arrangement flexibility. The final study sample included 102 employees that worked in various work arrangements that differed in degree of flexibility (i.e., office, remote, hybrid by personal choice, or hybrid by company policy). The
In an extensive analysis of seven coastal sites that are spread across the East and West coast of southern Sweden, animal economy and specialised hunting is at the forefront of interpreting the subsistence strategy and mobility in Mesolithic hunter-gatherer societies. Through comparative data, the following thesis will observe the differences and similarities between the aforementioned coastal reg
Outsourcing and contract manufacturing have developed as effective business strategies for electronics manufacturing services in the recent years. Most Consumer Electronic brand firms do not actually make the consumer products they sell but hire contract manufacturers, mostly in the developing world. Asia is currently the major production base of mobile phones for instance, with China and ASEAN ac
This essay examines the representation of women in Mad Men in relation to fashion and stereotypes. What does Mad Men say about feminism and femininity, and does the show reveal more about the contemporary view on feminism and gender than it does about the 1960’s? By analyzing the three female lead characters’ clothing this essay proves that there is a link between fashion and feminism, past and pr
“Amphawa” the district in Samutsongkram province where is plentiful of natural resources, local wisdoms and unique fascination of waterside living lifestyle, the area was trading and transportation hub of lower central and western part included of Thailand. Amphawa is widely well-known and people are able to define how the area was. Nowadays, technology and innovation magically shrink the world in
This research project presents an example of how students and teachers can work together to analyze Of Mice and Men. In this paper, critical theory is used as a form of scaffolding, in order to both develop students’ Theory of Mind (ToM) and make canonical literature more accessible. The research questions answered in this paper are concerned with asking how critical theory can be applied to the n
Technological development has been used to improve human conditions over time, but has in the process created detrimental impacts on the environment. As political forces shift the focus of technology to solve sustainability-related problems, much faith is put into that technologists will change the way they conduct their work so they create technologies that are more sustainable. Given the lack of
It is clear from evidence such as rotational curves and cosmic microwave background measurements that dark matter exists. The light dark matter experiment (LDMX) will search for dark matter in the sub-GeV range. It will do this using missing-momentum measurements of electrons interacting with a Tungsten target. The electron will recoil and be measured in the electromagnetic calorimeter (ECal) of t
The aim of this project is to analyse planetary boundary layer height (BLH) measurements from the Hyltemossa research station and find their dependence on seasonality, time of day, and air temperature. Further, investigation was made into the correlation between mass concentration of particulate matter with equivalent diameter<1μm (PM1) and black carbon (BC) aerosol and the BLH and how this varies
BACKGROUND: Postoperative pancreatic fistula (POPF) is the most important complication after left pancreatectomy. Superiority of hand-sewn closure or stapler closure of pancreatic stump in terms of short-term outcomes is not established. The aim of this study was to compare short-term surgical outcomes between the 2 modalities after left pancreatectomy. STUDY DESIGN: An international, multicenter,
Abstract Poor ovarian response (POR) in IVF can lead to cancelling a treatment cycle which is a physical and mental strain on the patient. To beforehand identify the patient’s ovarian response would possibly prevent the risk of unsuccessful stimulation. POR has been linked to polymorphisms in the FSH receptor. Using the FSHR genotype as prognostic criteria would permit individualisation of dosing
