Filtyp
Bronchodilatory substances such as the phosphodisterase inhibitor (PDE-I) theophylline stimulate mucociliary activity. With the introduction of selective PDE-Is it has become possible to study the functional importance of each phosphodiesterase enzyme (PDE) concerning the regulation of the ciliary beat. The effects of rolipram (inhibiting a cAMP specific PDE (PDE4), milrinone (inhibiting a cGMP in
The origins of early modern cult images are seldom easy to account for. Some of the images venerated in Italy in the Renaissance were already existing images which were suddenly activated by devotees claiming that the paintings were capable of performing miracles, while others were, according to circulating legends, ancient images painted by angels, St Luke, or even by a miracle. This article exam
In 2020, almost all research labs in industry, academia, and the government were shut down for long periods of time by political leaders to control the spread of the coronavirus. We consider the “micro” and “macro” implications of ongoing coronavirus disruptions in scientific research and the dissemination and commercialization of that research. We have identified three key unanswered research que
Allozyme data were used to assess the genetic structure between 37 sympatric populations of the species-pair Silene vulgaris and S. uniflora ssp. petraea, and to infer levels of intra- and interspecific gene flow in the two species. Silene vulgaris is a geographically widespread weed of disturbed habitats whereas S. uniflora ssp. petraea is endemic to the Baltic islands of Öland and Gotland. On Öl
By changing the institutionalised practices associated with resource distribution, the sharing economy could support sustainable urban transformations. However, its impacts on urban sus-tainability are unknown and contested, and key actors hold different perceptions about them. Understanding how they frame these impacts could help solve conflicts and outline what can be done to influence the devel
In the last 15 years or so, soft selective sweep mechanisms have been catapulted from a curiosity of little evolutionary importance to a ubiquitous mechanism claimed to explain most adaptive evolution and, in some cases, most evolution. This transformation was aided by a series of articles by Daniel Schrider and Andrew Kern. Within this series, a paper entitled “Soft sweeps are the dominant mode o
While the glucose transporter-4 (GLUT4) is fundamental to insulin-regulated glucose metabolism, its dynamic spatial organization in the plasma membrane (PM) is unclear. Here, using multicolor TIRF microscopy in transfected adipose cells, we demonstrate that insulin regulates not only the exocytosis of GLUT4 storage vesicles but also PM distribution of GLUT4 itself. In the basal state, domains (clu
This article studies the import of East German films by Swedish public service broadcaster Sveriges Radio, and their reception in the Swedish public sphere. While few GDR films reached theatrical distribution, Swedish television imported and broadcasted over 30 productions by the state-owned film studio DEFA during the 1970s and 1980s, making this the primary distribution window for East German fi
The Royal flagship Gribshunden carried the Danish King Hans on its way to the city of Kalmar in Sweden when the ship sank in the summer of 1495. The ship caught fire while anchored north of the Stora Ek o Island and sank to the seafloor, where it lies to this day. The wreck was rediscovered in the 1970s and is remarkably well preserved.Since 2001, scientific investigations have been performed on t
When developing reliable and useful models for selective laser melting processes of large parts, various simplifications are necessary to achieve computationally efficient simulations. Due to the complex processes taking place during the manufacturing of such parts, especially the material and heat source models influence the simulation results. If accurate predictions of residual stresses and def
We examine the impact of innovation disclosure through patenting on firms' cost of debt, focusing on the American Inventors Protection Act (AIPA) as an exogenous shock in innovation disclosure regulation. Post-AIPA, firms have an incentive to apply for patents only if commercial success is likely. Accordingly, we expect post-AIPA patents to be a better proxy for successful innovation activity, and
Purpose: Healthy spinal balance is dependent on spinal sagittal alignment. It is evaluated by several spinopelvic measures. The objective of this study is to investigate the effect of age and body mass index and the bone mineral density on the several vertebral measures and sagittal spinopelvic measurements. Methods: In this cross-sectional study, a total of 89 female patients were grouped accordi
Human carbonic anhydrases (hCAs) belong to a well characterized group of metalloenzymes that catalyze the conversion of carbonic dioxide into bicarbonate. There are currently 15 known human isoforms of carbonic anhydrase with different functions and distribution in the body. This links to the relevance of hCA variants to several diseases such as glaucoma, epilepsy, mountain sickness, ulcers, osteo
Mammographic sensitivity in breasts with higher density has been questioned. Higher breast density is also linked to an increased risk for breast cancer. Even though digital breast tomosynthesis (DBT) offers an attractive solution, for varied reasons it has not yet been widely adopted in screening. An alternative could be to boost the performance of standard mammography by using computer-aided det
People who spread misinformation in public debates expose others to the risk of forming false beliefs. Excluding them from participation can limit this exposure, but fact-checking takes up resources of time and money, and censorship violates social and political norms. Here, computer simulations of Bayesian learning in social networks suggest that, in some contexts anyway, the epistemic benefits o
The relative environmental impact from the building construction phase is increasing compared to the operation phase for new buildings. Therefore, it is important to consider the complete environmental life cycle of energy improvement measures. Many advanced optimization methods have been developed in recent years to assess building life cycle impact. However, these previous studies have not fully
How well can people identify semantic incongruities, which are often used in linguistic research and experimental psychology (e.g., Clifton, Staub, & Rayner, 2007)? Acceptability judgment tasks measure how natural a sentence sounds (e.g., Dąbrowska, 2010), and are often used with sentences with or without incongruities, but can these judgments be affected by expectation and bias? Two experimen
The summed probability distribution of 162 radiocarbon dates from Gotland was analysed with reference to archaeological and environmental data in order to evaluate possible variations in settlement intensity on the island. The data indicated variations in demographic development on the island, with probably several different colonization events and external influences; the pioneer settlement reach
This thesis delves into two ‘edge areas’ located in and around East Jerusalem. It attempts to unfold and analyze the dynamics in these edge areas, while investigating the agency of the people present there through their own perceptions and practices towards the land, the urbanization processes, the power circulation and the structural impositions. Squeezed by a settler-colonial domination that con
