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Background: The aim was to develop a theoretical framework for how errors in estimated activities propagate to a dispersion in time-integrated activity in radionuclide-therapy dosimetry and how this affects the comparison of radionuclide-therapy dosimetry schemes. Methods: Formulae for the variance of relative errors of estimated time-integrated activities and relative differences in time-integrat
The formation of a lipid vesicle from a lamellar phase involves a cost in bending energy of 100–1000 times the thermal energy for values of the membrane bending rigidity κ typical for phospholipid bilayers. The bending rigidity of a bilayer is however a strongly decreasing function of its thickness h, and the bilayer can thus reduce its bending energy by stretching (and thus thinning) the bilayer.
The tyrosine residue in amyloid-β (Aβ) is susceptible to attack by various reactive nitrogen intermediates, leading to the formation of 3-nitrotyrosine (3-NT), a post-translational modification associated with the pathophysiology of Alzheimer's disease (AD). Although considered a “dead-end” product, emerging evidence suggests that 3-NT can be reduced to 3-aminotyrosine (3-AT) in vivo. This study a
We show that for a positive linear operator acting in ℓ2 and defined from anxn+1 + bn xn + an-1xn-1 its so-called Friedrichs and Krein extensions may be explicitly characterized by boundary conditions as n → ∞.
The 1952 General Plan for Stockholm stands among Sweden’s most ambitious postwar planning documents, often cited as evidence for or against the large-scale ambitions of Welfare State modernism. Viewed through the lens of assemblage thinking, the plan does not appear as a self-referential, determinist blueprint subsuming social space. Instead, it is read as what this chapter calls a model assemblag
We consider a class of external potentials on the complex plane C for which the coincidence set to the obstacle problem contains a Jordan curve in the exterior of the droplet. We refer to this curve as a spectral outpost. We study the corresponding Coulomb gas at β=2[jls-end-space/].Generalizing recent work in the radially symmetric case, we prove that the number of particles which fall near the s
CONTEXT: Uptake of organic farming falls short of stated sustainability targets, particularly in highly productive regions where adoption could mitigate environmental impacts of intensive farming. Several hypotheses have been advanced to explain the constraints on adoption, but these have not been assessed within an integrative, interdisciplinary framework.OBJECTIVE: The objective was to develop a
Introduction: Treatment strategies for endometriosis have traditionally been biomedical. There is a need for a more multidimensional understanding of endometriosis and more targeted and individualized treatment interventions, including psychological approaches. Methods: The aims of this study were twofold: (1) to identify key biopsychosocial characteristics in individuals attending a tertiary clin
The Bcl-2 family of proteins governs mitochondrial outer membrane (MOM) permeabilization, a critical step in apoptosis that is dysfunctional in many cancers. Although cellular studies have long implicated direct interactions between the pore-forming apoptotic Bax protein and its opponent, the antiapoptotic Bcl-2 protein in apoptosis regulation, the underlying basic principles behind this control r
This study investigates how decision makers at the fire service responds to different types of information and how it can enhance fire service operations during incidents. Semi-structured interviews were conducted with 47 incident commanders from three countries (Sweden, Finland and USA) to assess the influence of pre-planned, real-time, and predictive information on decision-making. The results i
Autonomous vehicles (AVs) have been the subject of extensive research in recent years and are expected to completely transform the operation of transport networks and revolutionize the automotive industry in the coming decades. Modeling detailed interactions among vehicles with varying levels of penetration rates is essential for evaluating the potential effects. One such investigation is being pe
Integrating learning-based techniques, especially reinforcement learning, into robotics is promising for solving complex problems in unstructured environments. Most of the existing approaches rely on training in carefully calibrated simulators before being deployed on real robots, often without real-world fine-tuning. While effective in controlled settings, this framework falls short in applicatio
This paper address the role of music in relation to whathere is defined as cultural trauma. The text takes its starting point in Jeremy Eichler’s (2023) project on the music of remembrance, in which he shows how music bears witness to history and carries the memory of the past, using the cases of composers that lived through the 2nd WW and the Holocaust, the paper establishes acase of how music ma
Conservation grazing is widely used to manage open ecosystems, but inconsistent definitions and inadequate reporting of grazing patterns hinder effective communication among researchers, practitioners and policymakers, limiting the understanding and success of conservation grazing regimes. We demonstrate detailed measurement of the grazing pattern (comprising timing, intensity, duration and freque
To broaden our understanding of bradyarrhythmias and conduction disease, we performed common variant genome-wide association analyses in up to 1.3 million individuals and rare variant burden testing in 460,000 individuals for sinus node dysfunction (SND), distal conduction disease (DCD) and pacemaker (PM) implantation. We identified 13, 31 and 21 common variant loci for SND, DCD and PM, respective
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