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Niemann-Pick disease type C (NP-C) is a lysosomal storage disease in which impaired intracellular lipid trafficking leads to excess storage of cholesterol and glycosphingolipids in the brain and other tissues. it is characterized clinically by a variety of progressive, disabling neurological symptoms including clumsiness, limb and gait ataxia, dysarthria, dysphagia and cognitive deterioration (dem

In a previous report we used the Linked Dipole Chain model unintegrated gluon densities to investigate the uncertainties in the predictions for central exclusive production of scalars at hadron colliders. Here we expand this investigation by also looking at other parameterizations of the unintegrated gluon density, and look in more detail on the behavior of these at small k(<^>). We confirm our co

The original immunocompetence handicap hypothesis (ICHH) suggested that testosterone has a handicapping effect in males by both promoting the development of sexual signals and suppressing immune function. A modified version, the stress-linked ICHH, has recently proposed that testosterone is immunosuppressive indirectly by increasing production of corticosterone. To test both the original and stres

The main missions of the EuPA Education Committee (EuPA-EC) are to promote and enhance the quality of proteomics knowledge by creating educational programs and to initiate European-wide scientific exchange programs for young proteomics researchers. In this first report we present the initial actions we have undertaken in relation to the missions of the EuPA-EC, and the educational activities that

The Type 1 Diabetes Genetics Consortium (T1DGC), funded September 2002, is a collaborative effort to develop resources for the purpose of identifying risk genes for type 1 diabetes. One of the aims is to establish a renewable resource of DNA on 2500 affected sib-pair families. Regional networks have been established and in continental Europe, the European Type 1 Diabetes Genetics Network (ET1DGN)

Developmental instability and fluctuating asymmetry (FA) describe the inability of organisms to correct for random accidents under development and has become a major but controversial topic in evolutionary biology. Theoretical models predict that the level of FA should increase as a result of inbreeding, but empirical results are ambiguous. Moreover, the relationship between fitness and FA is stil

In 1980, Sweden was a highly regulated economy with several state monopolies and low levels of economic freedom. Less than twenty years later, liberal reforms turned Sweden into one of the world's most open economies with a remarkable increase in economic freedom. While there is resilience when it comes to high levels of taxes and expenditure shares of GDP, there has been a profound restructuring

OBJECTIVES: Measurement of transglutaminase autoantibodies (TGAA) is considered to be the most efficient single serologic test for celiac disease (CD) by the American Gastroenterological Association Institute. We hypothesized that a large international collaborative effort toward improving and standardizing TGAA measurement is both feasible and necessary. The primary aim of this workshop is to com

BACKGROUND: The study focused on investigating the effect of aminoguanidine on cardiovascular damages in diabetes and the possible mechanisms of its action. METHODS: Aminoguanidine (AMNG) was used to treat streptozotocin-induced diabetic rats, and the effects were compared to those obtained under insulin treatment. Blood metabolic parameters, *NO and ONOO- as well as protein carbonyl levels and ca

The effects of electrode thickness, electrolyte filling and current collector geometry on the performance of MCFC cathodes are investigated by using a steady state mathematical model. A two-dimensional pseudo-homogeneous model for the three-phase system in the cathode is used, which includes the polarisation curves from the heterogeneous agglomerate model[1] as local source functions. The model ta

The purpose of this paper is to investigate banking stability in countries where Negative Interest Rate Policies (NIRPs) are implemented, then study this stability by examining the relationships between policy interest rates and indicators of not only banking profitability but also capital adequacy, asset quality, and liquidity. The dataset used are the Financial Soundness Indicators (FSIs) collec

By exploring a case study of a Swedish media company, this thesis examines the roles of the middle management in influencing the decision-making of the top management and employees in decentralized innovation departments. For the top management’s decision-making, it was found that the middle manager performs an informing role, an inspiring role and a championing role, which are manifest on either

This paper addresses a gap in the open innovation in the emerging countries. The main purpose was to describe the open innovation in Russian better and contribute to academic literature. The study researches the effect of foreign ownership on open innovation in Russia. The study aims to better describe how foreign owned organizations build their open innovation network in Russia. It uses qualitati

Purpose: The purpose of this thesis is to provide an understanding of how consumer-brand relationships are affected by a radical rebranding strategy of a football club’s logo. This further leads the paper to contribute to the literature of consumer-brand relationships in the special context of football. Methodology: The interpretative nature of this research calls for a qualitative research appro

Title: The effect of cornerstone investors on the Swedish IPO market - An event study on underpricing, aftermarket performance and effects of cornerstone investors Seminar date: 2017-05-29 Course: BUSN79: Degree Project in Accounting and Finance: Corporate Financial Management, Master level, 15 ECTS Authors: Jonathan Engman & Markus Levéen Pehrson Supervisor: Maria Gårdängen Purpose: The