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Protease‐catalyzed peptide synthesis in acetonitrile water mixtures, containing 0–90% water, was investigated. α‐Chymotrypsin, as well as thermolysin, were deposited on solid supports, prior to exposure to the reaction media. Peptide syntheses were performed using both a kinetically controlled process (chymotrypsin) and an equilibrium‐controlled synthesis (thermolysin). The activity of chymotrypsi
We extend Burnashev's [5] classic result for the error exponent of discrete memoryless channels with feedback to the case of Markov channels with ISI and feedback. This is a nontrivial extension of our previous work [6] where we treated the case of Markov channels with feedback but without ISI. Tools from stochastic control theory are used to treat the case with ISI.
The progesterone metabolite, allopregnanolone (AlloP), is a GABAA receptor modulating steroid and is known to have orexigenic and pro-obesity effects. The neurobiological mechanisms underpinning these effects are most likely due to enhanced GABAergic signaling in the lateral arcuate nucleus (ARC) and medial paraventricular nucleus (PVN) of the hypothalamus. Inspired by the finding that GABAergic s
Atmospheric deposition is a source of inorganic nutrients and organic matter to the ocean, and can favor the growth of some planktonic species over others according to their nutrient requirements. Atmospheric inputs from natural and anthropogenic sources are nowadays increasing due to desertification and industrialization, respectively. While the impact of mineral dust (mainly from the Saharan des
Topical application of capsaicin is thought to deplete substance P from local sensory nerve terminals. In experiments on human skin inflammation was induced by injection of substance P (SP) or histamine intradermally, UV irradiation, non-immunologic contact urticaria, tuberculin reaction, contact allergens and benzalkonium chloride with or without capsaicin pretreatment. The flare response to SP a
The internal morphology of the crustacean larval form that Hansen (1899) called nauplius y has revealed a remarkably advanced early nauplius. The nervous system is well developed and differentiated. It is connected with the anlagen of the compound eyes. A presumed filamentous base of the SPX-organ connects with these. The nauplius eye is present in a three-partite form with two retinula cells in e
Gossypol at micromolar concentrations (2 μM) was found to inhibit axonal transport and a microsomal ATPase activity in the frog sciatic nerve, although axonal microtubules and the neuronal content of AMP, ADP and ATP were not affected. At slightly higher concentrations (30-40 μM), gossypol also inhibited microtubule assembly and neuronal energy metabolism. Gossypol accumulated in the nerve and the
The purpose of this study is to present and analyze previously unpublished quantitative agricultural data for the area on the shores of Lake Chad in Chad, and explore its relations to hydro-climatic factors (lake levels, rainfall and temperature). This is a rural area with livelihoods based on agropastoral and fishing activities, which are directly dependent on the region's high-varying hydro-clim
Repetition Repeats all Other Repetitions is a composition for 10-string guitar and electronics by Henrik Frisk. This is a CD release of the first version of the piece.
A generalized reaction scheme for the kinetic interaction of two reactants in a metabolic pathway has been examined in order to establish what minimal mechanistic patterns are required to support a damped oscillatory transient‐state kinetic behaviour of such a two‐component system when operating near a steady state. All potentially oscillating sub‐systems inherent in this scheme are listed and bri
The US Endangered Species Act (ESA) regulates what landowners, land managers, and industry can do on lands occupied by listed species. The ESA does this in part by requiring the designation of habitat within each listed species’ range considered critical to their recovery. Critics have argued that critical habitat (CH) designation creates significant economic costs while contributing little to spe
A negative association between interval length and infant and child mortality has been consistently identified in modern developing countries. The reasons for this association are unclear, however. Leading hypotheses explain these differences as a result of sibling competition, maternal depletion, infection transmission, or unobserved maternal factors, but none has received overwhelming support.
Aeolian–coastal sediments and landforms are excellent palaeoenvironmental archives, but chronological studies of coastal records are scarce in Sweden. In this study, we provide luminescence and radiocarbon ages of aeolian activity and coastal landscape evolution on the Kristianstad plain, SE Sweden, based on the investigations of two foredunes and two inland dunes at Åhus and Vittskövle. Additiona
The problem of identifying and correctly attributing speaker stance in human communication is addressed in this paper. The data set consists of political blogs dealing with the 2016 British referendum. A cognitive-functional framework is adopted with data annotated for six notional stance categories: concession/contrariness, hypotheticality, need/ requirement, prediction, source of knowledge, and
