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Niemann-Pick disease type C (NP-C) is a lysosomal storage disease in which impaired intracellular lipid trafficking leads to excess storage of cholesterol and glycosphingolipids in the brain and other tissues. it is characterized clinically by a variety of progressive, disabling neurological symptoms including clumsiness, limb and gait ataxia, dysarthria, dysphagia and cognitive deterioration (dem

In a previous report we used the Linked Dipole Chain model unintegrated gluon densities to investigate the uncertainties in the predictions for central exclusive production of scalars at hadron colliders. Here we expand this investigation by also looking at other parameterizations of the unintegrated gluon density, and look in more detail on the behavior of these at small k(<^>). We confirm our co

The original immunocompetence handicap hypothesis (ICHH) suggested that testosterone has a handicapping effect in males by both promoting the development of sexual signals and suppressing immune function. A modified version, the stress-linked ICHH, has recently proposed that testosterone is immunosuppressive indirectly by increasing production of corticosterone. To test both the original and stres

Developmental instability and fluctuating asymmetry (FA) describe the inability of organisms to correct for random accidents under development and has become a major but controversial topic in evolutionary biology. Theoretical models predict that the level of FA should increase as a result of inbreeding, but empirical results are ambiguous. Moreover, the relationship between fitness and FA is stil

In 1980, Sweden was a highly regulated economy with several state monopolies and low levels of economic freedom. Less than twenty years later, liberal reforms turned Sweden into one of the world's most open economies with a remarkable increase in economic freedom. While there is resilience when it comes to high levels of taxes and expenditure shares of GDP, there has been a profound restructuring

OBJECTIVES: Measurement of transglutaminase autoantibodies (TGAA) is considered to be the most efficient single serologic test for celiac disease (CD) by the American Gastroenterological Association Institute. We hypothesized that a large international collaborative effort toward improving and standardizing TGAA measurement is both feasible and necessary. The primary aim of this workshop is to com

BACKGROUND: The study focused on investigating the effect of aminoguanidine on cardiovascular damages in diabetes and the possible mechanisms of its action. METHODS: Aminoguanidine (AMNG) was used to treat streptozotocin-induced diabetic rats, and the effects were compared to those obtained under insulin treatment. Blood metabolic parameters, *NO and ONOO- as well as protein carbonyl levels and ca

The effects of electrode thickness, electrolyte filling and current collector geometry on the performance of MCFC cathodes are investigated by using a steady state mathematical model. A two-dimensional pseudo-homogeneous model for the three-phase system in the cathode is used, which includes the polarisation curves from the heterogeneous agglomerate model[1] as local source functions. The model ta

Based on the body of evidence implicating ocular blood flow disturbances in the pathogenesis of glaucoma, there is great interest in the investigation of the effects of antiglaucoma drugs and systemic medications on the various ocular vascular beds. The primary aim of this article was to review the current data available on the effects of antiglaucoma drugs and systemic medications on ocular blood

Capillary electrophoresis of nucleic acids has recently employed gels of self-assembled uncharged triblock copolymers as sieving media. Pluronic F127 contains poly(ethylene oxide) (EO) and poly(propylene oxide) (PO) with the block structure (EO)(106)(PO)(70)(EO)(106). Aqueous solutions of 30% w/w of this polymer are liquids at low temperatures but above 11 degreesC the polymers assemble to micelle

The Sahel belt of Africa has been the focus of intensive scientific research since the 1960s, spurred on by the chronic vulnerability of its population to recurring drought and the threat of long-term land degradation. But satellite sensors have recently shown that much of the region has experienced significant increases in photosynthetic activity since the early 1980s, thus re-energizing long-sta

In this correspondence the error exponent and the decoding complexity of binary woven convolutional codes with outer warp and with binary convolutional codes as outer and inner codes are studied. It is shown that an error probability that is exponentially decreasing with the product of the outer and inner code memories can be achieved with a nonexponentially increasing decoding complexity

ABSTRACT: This study is the third within the project Sound, Music, and Eye Movements, and results from the two previous studies examining reading for comprehension revealed no effects on eye movements such as fixation durations and saccade amplitudes with regards to sound environments. Therefore, other eye movement measures were tested in the current study, namely oculomotor control. Participants

The paper investigates a model for authentication in which not only an outsider, but also the transmitter or the receiver, may cheat. Lower bounds on the probability of success for different types of deception as well as on the parameters of secure authentication codes are derived. The latter bounds are shown to be tight by demonstrating codes in projective space that meet the bounds with equality

It is demonstrated that an accurate approximation of the screening function is crucial for a quantitative evaluation of the XPS asymmetry index α. It is also shown that the dynamical aspects of the valence electron response are important in order to get an accurate description of the XPS spectrum at finite distances from the threshold.(23 refs)