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Kristallin nanocellulosa i vattensuspensioner självordnar till vackra, iriserande, kiralt ordnade filmer om vattnet i suspensionen låts evaporera bort över några dagar. Denna processen kallas evaporation induced self-assembly. Filmernas egenskaper kan påverkas genom tillsättning av additiv till startsuspensionen och denna effekt har undersökts, men sällan med mer än ett additiv åt gången. För att
Hepatobiliary excretion can be a major clearance pathway dictating the pharmacokinetics of drugs. Quantitative prediction of human hepatobiliary excretion of drugs is thus essential in early drug development. Extrapolations from current in vitro models are challenging due to differences in expression of enzymes and transporters from native liver tissue. This study aims to utilise 3D spheroids of p
Since 1986, the Vietnamese socialist state has gradually opened towards the global market. Subsequently, socialist modernity may increasingly be outrivaled by the individualistic culture associated with global capitalism which is now gaining ground in Vietnam, especially among the urban middle-class who can easily access it. Proceeding from a post-colonial feminist framework, this thesis aims to i
This thesis focuses on participatory development discourse in Sweden’s support to civil society in developing countries, channelled through Swedish civil society organisations with which Sida has framework agreements. The thesis uses a modified version of Norman Fairclough’s critical discourse analysis, with an operationalisation of participatory development discourse that defines it as either for
Neuroepithelial stem (NES) cells derived from induced pluripotent stem cells (iPSCs), hold promise as a novel cell therapy for treating various neurological disorders such as, neurodegenerative diseases, spinal cord injury, and stroke. NES cells’ therapeutic potential lies in their ability to differentiate into multiple cell types and restore neuronal function. However, in order for this therapeut
The UN-affiliated World Health Organization (WHO) estimated that in 2019, more than 90 % of people living on Earth were constantly exposed to concentrations of ambient outdoor pollutants higher than the air quality guideline limits. One of the most notorious air pollutants is particulate matter, consisting of fine natural or anthropogenic particles suspended in the air. Recent studies have shown t
Anthropogenic noise is an increasing form of environmental change that alters natural soundscapes. Human activities, including road traffic, have led to a notable increase in ambient noise, which may impair how animals use their sensory systems to fulfill vital activities. Previous experiments suggest that noise affects the hunting behavior of nocturnal predators, but it is still scarcely document
Background/Objectives: Irritable bowel syndrome (IBS) is presented with both gastrointestinal and extraintestinal symptoms. In addition, overweight/obesity and metabolic syndrome is prevalent in IBS. Dietary interventions with a low content of fermentable oligo-, di-, and monosaccharides and polyols (FODMAP) or a starch- and sucrose-reduced diet (SSRD) efficiently reduce symptoms and weight. Our h
Human-induced habitat loss, fragmentation and degradation are among the leading causes of species decline worldwide. This is particularly true in tropical forests, where unique, often highly specialized fauna is under threat. By altering resource availability, anthropogenic habitat change can impose resource constraints on animals and may influence their allocation of resources to competing life h
Background Obsessive-compulsive disorder (OCD) is associated with an increased risk of cardiometabolic disorders. We developed a lifestyle intervention, named LIFT, aimed at improving lifestyle habits (physical activity, diet, alcohol and tobacco use, stress, sleep) and reducing cardiometabolic risk factors in OCD. Aims This study aimed to establish the feasibility and acceptability of LIFT, evalu
Using a mixed-methods approach, we assessed understanding of risks from exposure to the non-threshold carcinogen hexavalent chromium (Cr(VI)) among workers (n = 113) and occupational health and safety managers (n = 13) at 14 worksites with potential exposure to Cr(VI). We found that 55% of the workers had a measurable concentration of inhalable Cr(VI), with 19% exceeding 1 µg/m3, a level that corr
Although variation in effect sizes and predicted values among studies of similar phenomena is inevitable, such variation far exceeds what might be produced by sampling error alone. One possible explanation for variation among results is differences among researchers in the decisions they make regarding statistical analyses. A growing array of studies has explored this analytical variability in dif
Aim: The degree to which species' niches remain stable over space and time–the niche conservatism hypothesis–is critical for predicting species' responses to environmental change. Tests of this hypothesis typically focus on changes in niche centroids and boundaries. An outstanding question is whether species' environmental associations differ within the interior of their niche space–that is, acros
The thesis explores the migration experiences of Syrian refugees who arrived in Sweden and Denmark by crossing the Mediterranean Sea in small, precarious boats. It aims to illuminate how these refugees managed the risks they faced during their journey to Europe and the meanings they associated with these risks. The research focuses on the socio-cultural and individual contexts within which risk is
Introduction: There is no recommendation regarding the optimal prime solution for the cardiopulmonary bypass circuit in adult cardiac surgery. Despite the lack of scientific evidence, mannitol has frequently been added to the prime solution with intention to prevent acute kidney injury. The aim of this study was to investigate the impact of mannitol in cardiopulmonary bypass circuit prime in patie
Purpose: Among visually Tau-PET-positive scans, large variation exists in the size of the visually tau-positive area. Here, we propose a metric quantifying the spatial extent of visual Tau-PET-positivity, termed “TAU-SPEX”, and evaluate associations with visual read status, neurofibrillary tangle (NFT) pathology at autopsy, and cognition. Methods: [18F]flortaucipir data from 1,645 participants (ag
Introduction: Familial risk of lung cancer (LC) is at the level of many common cancers (ca 2.0) but as cigarette smoking is the main cause of LC, it has remained undefined to what extent smoking contributes to the familial risk. We take advantage of the natural experiment of divorce. In Sweden, it has been customary that children stay with their mother after divorce. We thus hypothesize that only
N1-methyladenine (m1A), a modification of transcripts, regulates mRNA structure and translation efficiency. In a recent issue of Nature, Sun et al. reported that m1A in CAG repeat RNA contributes to CAG repeat expansion-induced neurodegeneration in Caenorhabditis elegans and Drosophila through enhancing the ability of endogenous TDP-43 to partition into stress granules mediated by m1A. The study i
Ubiquitously used for monitoring pipelines and infrastructures, distributed fibre-optic acoustic sensing is becoming an emerging technology for earthquake monitoring thanks to the possibility to interrogate a large vast of distances with a dense number of sensing points in which an optical fiber cable can be retrofitted. Moreover, it can also be used as a tool by geophysicists for the characteriza
A central challenge in water electrolysis lies with the oxygen evolution reaction (OER) where the formation of molecular oxygen (O2) is hindered by the constraint of angular momentum conservation. While the reactants OH− or H2O are diamagnetic (DM), the O2 product has a paramagnetic (PM) triplet ground state, requiring a change in spin configuration when being formed. This constraint has prompted
