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Strain has frequently been suggested to play an important role in the function of several proteins. In this paper, we review various definition of strain and discuss how it may be quantified. We show that covalent strain (i.e. strain caused by covalent interactions) plays a minor role for the function of all proteins we have studied, e.g. blue copper proteins, desulforedoxin, CuA in cytochrome c o
A helicopter flying through an atmosphere containing particulates may accumulate high electrostatic charges which can challenge its operational safety. In this paper we report on the in uence of the helicopter configuration on its electrification. Our study is based on a recently developed numerical approach according to which the turbulent air flow around the rotorcraft is estimated via large edd
Onshore wind turbines are becoming increasingly widespread globally, with the associated net effect that a greater number of people will be exposed to wind turbine noise (WTN). Sleep disturbance by WTN has been suggested to be of particular importance with regards to a potential impact on human health. Within the Wind Turbine Noise Effects on Sleep (WiTNES) project, we have experimentally investig
Trabecular bone is viscoelastic under dynamic loading. However, it is unclear how tissue viscoelasticity controls viscoelasticity at the apparent-level. In this study, viscoelasticity of cylindrical human trabecular bone samples (n = 11, male, age 18–78 years) from 11 proximal femurs were characterized using dynamic and stress-relaxation testing at the apparent-level and with creep nanoindentation
The adult adaptive immune system is comprised of a wide spectrum of lymphocyte subsets with distinct antigen receptor repertoire profiles, effector functions, turnover times and anatomical locations, acting in concert to provide optimal host protection and self-regulation. While some lymphocyte populations are replenished by bone marrow hematopoietic stem cells (HSCs) through adulthood, others eme
In this paper we consider random distance graphs motivated by applications in neurobiology. These models can be viewed as examples of inhomogeneous random graphs, notably outside of the so-called rank-1 case. Treating these models in the context of the general theory of inhomogeneous graphs helps us to derive the asymptotics for the size of the largest connected component. In particular, we show t
Timetables are important for train punctuality. However, relatively little attention has been paid to the people who plan the timetables: the research has instead been more centred on how to improve timetables through simulation, optimisation, and data analysis techniques. In this study, we present an overview of the state of practice and the state of the art in timetable planning by studying the
The combined quantum mechanical (QM) and molecular mechanical (MM) approach (QM/MM) is a popular method to study reactions in biochemical macromolecules. Even if the general procedure of using QM for a small, but interesting part of the system and MM for the rest is common to all approaches, the details of the implementations vary extensively, especially the treatment of the interface between the
Understanding the relationships between snow and vegetation is important for interpretation of the responses of alpine ecosystems to climate changes. The Qinghai-Tibetan Plateau is regarded as an ideal area due to its undisturbed features with low population and relatively high snow cover. We used 500 m Moderate Resolution Imaging Spectroradiometer (MODIS) datasets during 2001–2010 to examine the
Background: Knee arthroscopy is one of the most common surgical procedures worldwide and the number of arthroscopies has substantially increased in the last 30 years. Thus, our aim was to provide updated estimates on the risk of complications and compare it with the background risk in the general population. Methods: We identified patients aged 15-84 years with knee arthroscopy in the years 2005-2
Obesity is closely associated to several diseases such as type 2 diabetes, cardiovascular disease, hepatic steatosis, airway disease, neurodegeneration, biliary diseases and certain cancers. It is, therefore, of importance to assess the role of nutrition in disease prevention as well as its effect in the course of such pathologies. In the present study, we addressed the impact of the exposure to d
We consider the perturbation of an electric potential due to an insulating inclusion with corners. This perturbation is known to admit a multipole expansion whose coeffcients are linear combinations of generalized polarization tensors. We define new geometric factors of a simple planar domain in terms of a conformal mapping associated with the domain. The geometric factors share properties of the
The increased stiffness of a tumor triggers a multitude of responses that aid cancer cell dissemination. Stiffness-induced expression of CCN1 mediates autocrine signaling in the endothelium to upregulate N-Cadherin levels. This permits more stable interactions with cancer cells and increases their ability to spread into the circulation.
According to the International Energy Agency about 14% of greenhouse gases (GHG) are generated by the transportation sector globally and this share is estimated to increase to 50% by 2030. At the same time consumption of mobility is continuously increasing, making it one of the most crucial sectors to focus on for sustainable consumption. Several measures and policies are being implemented to redu
Technological developments of the last decades allow the production and the dispersion of particles of sizes ranging between 10 and 100 nm in liquids. In a large number of recent studies the resulting nanofluids have been reported to display anomalously high increase in convective heat transfer. The present study compiles experiments from five independent research teams investigating convective he
We investigate the backscattering of low-power millimeter-wave pulses (wavelets) on the human hand in order to determine the detection limit of scattering features. Using an in-house wavelet radar setup with a nominal spatial resolution of 2.29 cm, we measure a hand in three different postures: a flat hand, a fist, and a hand with raised index finger. For the latter, we are able to resolve backsca
Pancreatic islets rich in beta-cells were isolated from non-inbred ob/ob-mice and used for studying various aspects of the function of the plasma membrane. A review is given of the authors' work along the following lines: the role of transmembrane transport or membrane binding in the recognition of insulin-releasing sugars, amino acids, sulfonylureas, and sulphydryl-blocking agents; the role of cy
