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Mutualism, interspecific cooperation that yields reciprocal benefits, can promote species coexistence, enhancing biodiversity. As a specific form of mutualism, cross-feeding, where each of two mutualists produces a resource the other one needs, has been broadly studied. However, few theoretical studies have examined competition between cross-feeding mutualists and cheaters, who do not synthesize r

The technique to perform adnexectomy for adnexal masses has shifted over the last decades, from open surgery towards minimally invasive approaches. At the same time caution is warranted to prevent perioperative intra-abdominal spilling of cyst content which can be a challenge especially for very large masses. vNOTES (vaginal Natural Orifice Transluminal Endoscopic Surgery) combines a vaginal appro

Background: The transition process from being an occupational therapy student to becoming an occupational therapist has been shown to be stressful, with an increased risk of burnout and job turnover. Consequently, there is a need to gain a deeper understanding of this process in order to identify ways of making it easier. Aims/objectives: To describe newly graduated Swedish occupational therapists

Hypomethylating agents (HMAs) are frontline therapies for Myelodysplastic Neoplasms (MDS) and Acute Myeloid Leukemia (AML). However, acquired resistance and treatment failure are commonplace. To address this, we perform a genome-wide CRISPR-Cas9 screen in a human MDS-derived cell line, MDS-L, and identify TOPORS as a loss-of-function target that synergizes with HMAs, reducing leukemic burden and i

INTRODUCTION: Providing medical advice regarding lifestyle changes is currently the most effective intervention for delaying dementia onset among individuals with subjective cognitive decline (SCD). Adherence to such advice can be influenced by individual's social environment. We measured that impact within a Latinamerican population. METHODS: We recruited 183 SCD individuals from a Memory Clinic,

Objective: To generate a list of candidate items potentially useful for discriminating individuals with Early-stage Symptomatic Knee Osteoarthritis (EsSKOA) from those with other conditions and from established osteoarthritis (OA), and to reduce this list based on expert consensus. Design: We conducted a three-round online international modified Delphi exercise with OA clinicians and researchers (

Haematopoietic stem cell (HSC) self-renewal is a process that is essential for the development and homeostasis of the blood system. Self-renewal expansion divisions, which create two daughter HSCs from a single parent HSC, can be harnessed to create large numbers of HSCs for a wide range of cell and gene therapies, but the same process is also a driver of the abnormal expansion of HSCs in diseases

UVA radiations contribute up to 95% of the total UV exposure and are known to induce cell damage, leading to apoptosis. Since the benefic effects of ascorbic acid on human health are well known, a new tomato genotype (named DHO4), highly rich in ascorbic acid, has been recently obtained. Here, we compared the effects of ascorbic acid and hydrophilic DHO4 extracts in protecting human keratinocytes

High quality research data and analytical code are essential for ensuring the credibility of scientific results, are key research outputs, and are crucial elements to facilitate reproducibility. However, in ecology and evolution (E&E) in particular, it is currently unknown how many journals have policies on data- and code-sharing for peer review purposes, or upon manuscript acceptance. Further

An appealing procedure to obtain operating pressures in the 10-8 Pa range, which is necessary for the insertion devices elements of synchrotron sources, is to coat the inner ultra-high vacuum chamber walls with a thin film of non-evaporable getter (NEG) metals. Titanium, zirconium, vanadium, and their alloys are used as NEG materials due to their low activation temperature, high chemical activity,

Pollinators have been negatively impacted by agricultural intensification, loss of natural habitats and habitat fragmentation. This has raised concern about the persistence of plant species dependent on insect pollination in semi-natural grasslands where these are remnants of larger grazed areas, now surrounded by intensive agriculture and forests. To better understand landscape composition effect

Intimate partner violence (IPV) is a global issue requiring a thorough understanding of risk factors to inform prevention strategies. This study applies Kraemer et al.‘s (2005) categorization system to classify risk factors for IPV perpetration, addressing two research questions: 1) What variables or attributes are commonly employed to assess the risks associated with IPV perpetration, and how can

Developing bones can be severely impaired by a range of disorders where muscular loading is abnormal. Recent work has indicated that the effects of absent skeletal muscle on bones are more severe early in development, with rudiment length and mineralization lengths being almost normal in muscle-less limbs just prior to birth. However, the impact of abnormal mechanical loading on the nanoscale stru

Recent research on normal human tissues identified omnipresent clones of cells, driven by somatic mutations known to be responsible for carcinogenesis (e.g., in TP53 or NOTCH1). These new insights are fundamentally changing current tumor evolution models, with broad oncological implications. Most studies are based on surgical remnant tissues, which are not available for many organs and rarely in a

X-ray fluorescence emission spectroscopy is a powerful tool to gain chemical information on a wide variety of samples. Its combination with focused X-ray beams and translation stages enables X-ray fluorescence microscopy, generating quantitative distribution maps for sets of chemical elements, depending on incident photon energy and detector specifications. The use of synchrotron radiation for X-r

In analyses of affordances and opportunities in different neighbourhoods it is found that access to public buildings and a well-functioning public space are of outmost importance. This is found to be especially important in neighbourhoods having a population with fewer resources, areas often discussed in terms as ‘deprived’ or ‘excluded’, concepts that alludes to the phenomenon of segregation. Pre