Filtyp
Larger plastic pieces break down into micro- and eventually nano-sized plastics. This makes nanoplastics ubiquitous in the environment, giving rise to great concern for its effect on biota. Many studies use polystyrene nanoparticles (PS-NPs) as a model for nanoplastics, showing a negative impact on various organisms, but the molecular effects are yet not fully explored. Here we applied 1H nuclear
AIMS: Heart failure (HF) is a frequent condition in the elderly, further complicated by associated pulmonary hypertension (PH), with impact on morbidity and mortality. Plasma proteins associated with cardiovascular disease, related to inflammation, neurohormonal changes, and myocyte stress, pathways recognized in the pathophysiology of HF, may provide information on disease severity and prognosis.
In this study, we use the photosynthetic purple bacterium Rhodobacter sphaeroides to find out how the acclimation of photosynthetic apparatus to growth conditions influences the rates of energy migration toward the reaction center traps and the efficiency of charge separation at the reaction centers. To answer these questions we measured the spectral and picosecond kinetic fluorescence responses a
Background: Molecular signatures in prostate cancer (PCa) tissue can provide useful prognostic information to improve the understanding of a patient's risk of harbouring aggressive disease. Objective: To develop and validate a gene signature that adds independent prognostic information to clinical parameters for better treatment decisions and patient management. Design, setting, and participants:
For deformable registration of computed tomography (CT) scans in image guided radiation therapy (IGRT) we apply Riemannian elasticity regularization. We explore the use of spatially varying elasticity parameters to encourage bone rigidity and local tissue volume change only in the gross tumor volume (GTV) and the lungs. We evaluate the method on the point-validated 4DCT breathing thorax POPI-model
A constitutive model for concrete is formulated. Tensile fracture is described using a smeared crack approach where the fracrure energy is considered and the shear stiffneess in the cracked region is gradually reduced as crackling develops. Environmentally induced strain due to variation of moisture and temperature is taken into account and may be made dependent on the stress state. Creep is model
Objective: Blood biomarkers of neuronal injury such as neurofilament light (NfL) show promise to improve diagnosis of neurodegenerative disorders and distinguish neurodegenerative from primary psychiatric disorders (PPD). This study investigated the diagnostic utility of plasma NfL to differentiate behavioural variant frontotemporal dementia (bvFTD, a neurodegenerative disorder commonly misdiagnos
The inability to culture hematopoietic stem cells (HSCs) in vitro hinders the full study of physiologic and pathologic hematopoiesis “in a dish.” Recent efforts have been taken to generate HSCs via transcription factor (TF) mediated reprogramming. Most of these studies, however, rely on lentiviruses capable of genomic integration, running the risk of insertional mutagenesis and oncogenesis. Applic
Qdenga® has been approved by the European Medicines Agency (EMA) for individuals > 4 years of age and for use according to national recommendations. The vaccine shows high efficacy against virologically confirmed dengue and severe dengue in clinical studies on 4–16-year old's living in endemic areas. For individuals 16–60 years old only serological data exists and there is no data for individuals
The ongoing climate change can modulate the behavior of global vegetation and influence the terrestrial biosphere carbon sink. Past observation-based studies have mainly focused on the linear trend or interannual variability of the vegetation greenness, but could not explicitly deal with the effect of natural decadal variability due to the short length of observations. Here we put the variabilitie
Due to its potential geo-political and environmental implications, climate migration is an increasing concern to the international community. However, while there is considerable attention devoted to migration in response to sea-level rise, there is a limited understanding of human mobility due to freshwater and inland hydroclimatic changes. Hence, the aim of this paper is to examine the existing
This research explores teacher educators' self-reported preparedness to teach students with special educational needs. Teacher educators are concerned with preparing the next generation of teachers who will, in turn, be addressing the needs of students with special educational needs within schools. Being able to address this important task also in their own teaching at the teacher education progra
Hydropower is a clean and efficient technology for producing renewable energy. Assessment and forecasting of hydropower production are important for strategic decision-making. This study aimed to use machine learning models, including adaptive neuro-fuzzy inference system (ANFIS), gene expression programming, random forest (RF), and least square support vector regression (LSSVR), for predicting hy
The rising price and demand for energy are significant issues for the food sector, which consumes a substantial amount of energy throughout the supply chain. Hence, improving energy efficiency has become an essential priority for the food sector. However, most food businesses have limited awareness of the recent technological advancements in real-time energy monitoring. Thus, the concept of “Inter
The oxidation of aromatics contributes significantly to the formation of atmospheric aerosol. Using toluene as an example, we demonstrate the existence of a molecular rearrangement channel in the oxidation mechanism. Based on both flow reactor experiments and quantum chemical calculations, we show that the bicyclic peroxy radicals (BPRs) formed in OH-initiated aromatic oxidation are much less stab
Regular exercise leads to widespread salutary effects, and there is increasing recognition that exercise-stimulated circulating proteins can impart health benefits. Despite this, limited data exist regarding the plasma proteomic changes that occur in response to regular exercise. Here, we perform large-scale plasma proteomic profiling in 654 healthy human study participants before and after a supe
