Filtyp
Streptococcus pyogenes is the causative agent in a wide range of diseases in humans. Thrombin-activatable fibrinolysis inhibitor (TAFI) binds to collagen-like proteins ScIA and ScIB at the surface of S. pyogenes. Activation of TAFI at this surface redirects inflammation from a transient to chronic state by modulation of the kallikrein/kinin system. We investigated TAFI binding characteristics to S
Background and Purpose-Previous studies suggest that genetic variation plays a substantial role in occurrence and evolution of intracerebral hemorrhage (ICH). Genetic contribution to disease can be determined by calculating heritability using family-based data, but such an approach is impractical for ICH because of lack of large pedigree-based studies. However, a novel analytic tool based on genom
Clonal plants from poor habitats benefit less from morphologically plastic responses to heterogeneity than plants from more productive sites. In addition, physiological integration has been suggested to either increase or decrease the foraging efficiency of clonal plants. We tested the capacity for biomass production and morphological response in two closely related, rhizomatous species from habit
Detraditionalization in late modernity has both affected traditional religion and the domain of clinical therapy. Sweden, which is said to be one of the most secularized societies in the world, instead has allowed the public domain to be colonized by new, spiritualized practices. Sold as therapy, the services of new spiritual leaders offer anti-stress techniques to prevent burn-out, or leaders are
In 1996 there was no convincing laboratory evidence that EMFs used in wireless communication could cause tumour promotion at non-thermal exposure levels. Therefore we then performed a study of the effects from exposure to such electromagnetic fields in the rat brain glioma model we were using in our research for brain tumour therapy. By stereotaxic technique rat glioma cells (RG2 or N32) were inje
To identify markers of non-response to neoadjuvant chemotherapy (NAC) that could be used in the adjuvant setting. Sixteen pathologists of the European Working Group for Breast Screening Pathology reviewed the core biopsies of breast cancers treated with NAC and recorded the clinico-pathological findings (histological type and grade; estrogen, progesterone receptors, and HER2 status; Ki67; mitotic
This paper concerns the use of sequential Monte Carlo methods (SMC) for smoothing in general state space models. A well-known problem when applying the standard SMC technique in the smoothing mode is that the resampling mechanism introduces degeneracy of the approximation in the path space. However, when performing maximum likelihood estimation via the EM algorithm, all functionals involved are of
Popular Abstract in Swedish Oönskade reaktioner efter vaccination och allergenspecifik immunoterapi - Kontaktallergi för aluminium och kliande knutor För att ett vaccinationsprogram ska fungera krävs kontinuerlig uppföljning av vaccinernas säkerhet vad gäller eventuella oönskade reaktioner. Under de senaste 10 till 15 åren har en ökad oro noterats bland allmänhet och profession beträffande oönskadThe aim of the work presented in this thesis was to investigate two different types of adverse reactions, persistent itching nodules and contact allergy to aluminium, after immunization with aluminium-containing vaccines and aluminium-containing allergen extracts used for allergen-specific immunotherapy (ASIT). The first paper describes active parental reporting of adverse events (AEFIs) after a
The transparency regulator hypothesis (TRH) proposes that ultraviolet radiation (UVR) is a main driving force behind diel vertical migration (DVM) of zooplankton in clearwater systems. While previous studies have mainly studied DVM in relation to the TRH on a spatial scale across systems we here focus on long-term trends in a single system in order to assess if UVR explains observed patterns in DV
Recently, we constructed a focused antibody library tailored to interact with haptens. High functionality of this library was demonstrated, as specific binders could be retrieved to a range of different haptens. In the current study we have developed a mutagenesis and selection strategy in order to further fine-tune the hapten binding properties of these antibody fragments. Testosterone was chosen
Animal and a few human studies suggest that polybrominated diphenyl ethers (PBDEs) may affect male reproductive function. The aim of the present study was to evaluate if male reproductive function was associated with serum level of PBDEs. We evaluated, in a cross-sectional study, the effects of environmental exposure to BDE-47 and BDE-153 on reproductive hormones and semen quality, including marke
Purpose – The purpose of this paper is to explore how students construct narratives of themselves as information seekers in a school context where their descriptions of their information activities are assessed and graded. Design/methodology/approach – Blog posts on credibility judgements written by 28 students at a Swedish upper secondary school were analysed through a bottom-up coding process b
The nature of warfare is changing in ways that increasingly endanger women and girls. Besides suffering from the general brutality inflicted by violent conflict, women also suffer particular attacks whose form is defined by distinct notions of female sexuality. However, the ironic fact must be recognized that the upheaval of a conflict can break down social barriers and traditional patriarchal pat
The present thesis explores the interface between copyright, competition and human rights in the outfit of knowledge society through the balance between both sides of the purpose of copyright, namely to encourage a dynamic creative culture, while returning value to creators and to provide widespread, affordable access to content for the public. The landscape of intellectual property generally and
The purposes of this thesis is study the European Court of Justice from a non legal perspective and investigate the courts possibility to advance its own preferred goals rather that of the member states in cases of non-compliance. Drawing on general principal-agent theory I construct a model from which I derive certain hypothesis mainly about under what circumstances we should expect the Court to
Billions around the world require access to effective learning opportunities if we are to create a sustainable world. E-learning represents one of the tools we can utilize to help deliver these learning opportunities. Unfortunately, the e-learning field is young and many of those working on its development have failed to build upon one another's progress. This thesis addresses key elements in
As the country aiming to join the European Union, Georgia will need to be able to comply with the EU requirements. This applies to the waste management sector as well. The thesis focuses on the situation with the municipal solid waste management in Georgia illustrated with the case of its capital, Tbilisi. The backcasting approach is used to find out the way that will improve the situation in the
Financial return series are often characterized by volatility clusters and a leptokurtic distribution. Many models that account for these properties exist, with the GARCH model proposed by Bollerslev (1986) being the most popular. This thesis explores an alternative model to capture the stochastic volatility in financial time series. The considered model is denoted the autoregressive gamma varianc
Industry Foundation Classes (IFC) models from the Architecture, Engineering and Construction (AEC) -industries can contain information on building life-cycle entities. Urban planning and related domains are interested in data conversions between IFC and City Geography Markup Language (CityGML) because of this. However, the maintenance and versioning of CityGML life-cycle building data poses a s
Microbial decomposers breakdown soil organic matter, releasing carbon dioxide (CO2) to the atmosphere. This release of CO2 could therefore contribute to future climate change. However, microbial decomposers might also be affected by climate change, as for example the intensity and frequency of drought and rainfall events are expected to increase, resulting in more drying-rewetting (D/RW) events in
