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Background Quadrivalent human papillomavirus (HPV types 6/11/16/18) L1 VLP vaccine is highly effective in preventing HPV 6/11/16/18-related cervical and external genital disease. Herein, we evaluated the impact of the quadrivalent HPV 6/11/16/18 L1 VLP vaccine on prevention of HPV-associated cervico-genital lesions in a broad population of sexually active European women. Methods Female subjects (N
The risk of gastric cancer (GC) associated with dietary intake of nitrosodimethylamine (NDMA) and endogenous formation of nitroso compounds (NOCs) was investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC). The study included 521 457 individuals and 314 incident cases of GC that had occurred after 6.6 average years of follow-up. An index of endogenous NOC (ENOC) fo
Members of the bone morphogenetic protein-1/tolloid (BMP-1/Tld) family of metalloproteinases, also known as procollagen C-proteinases (PCPs), control multiple biological events ( including matrix assembly, cross-linking, cell adhesion/migration and pattern formation) through enzymatic processing of several extracellular substrates. PCP activities on fibrillar procollagens can be stimulated by anot
Popular Abstract in Swedish Vård och behandling av akut postoperativ och cancer-relaterad smärta: Patienters erfarenheter och uppfattningar i förhållande till hälsorelaterad livskvalitet och smärtans dimensioner Trots att det finns effektiva behandlingsmetoder för patienter med postoperativ smärta och cancer-relaterad smärta så lider många patienter av smärta. Denna avhandling beskriver patienterThis thesis describes patients in acute postoperative pain as well as patients with acute cancer-related pain in palliative care, and their experiences and perceptions of pain management in relation to HRQOL and the multidimensionality of pain. A combination of qualitative and quantitative methods was chosen. Data were collected using interviews and questionnaires; APS, SF:36 and a new developed q
The ubiquitin E3 ligase Cbl has been shown to negatively regulate tyrosine kinase receptors, including the stem cell factor receptor/c-Kit. Impaired recruitment of Cbl to c-Kit results in a deregulated positive signalling that eventually can contribute to carcinogenesis. Here, we present results showing that Cbl is activated by the SFKs (Src family kinases) and recruited to c-Kit in order to trigg
We used the tropical oceanic planktonic diatom species Nitzschia marina, Rhizosolenia bergonii and Azpeitia africana/Azpeitia neocrenulata, most commonly found in the surface sediments of the northeastern most South China Sea (SCS) where the Kuroshio Current enters the SCS through the Bashi Strait north of Luzon, to analyse the influence of the the Kuroshio Current on the SCS. The impact of the Ku
Background Earlier reports on reduced physical performance and osteoporosis-related fractures have mostly been short-term studies. The aim of this investigation was to examine the effects of fractures on physical functioning 3 years after trauma, the latter being stratified for pain. Participants and methods The study consisted of a population-based case-control study including 289 subjects from t
Objectives To create reference values representative of normal findings on two-dimensional (2D) and three-dimensional (3D) transvaginal ultrasound (TVS) examination of the cervix from 17 to 41 weeks' gestation and to determine the agreement between cervical measurements taken by 2D and 3D TVS. Methods Cross-sectional study covering 17 to 41 weeks in 419 nulliparous and 360 parous women who deliver
Circling behaviour in unilateral 6-OHDA-lesioned rats is interpreted as being opposite in direction to the side of the brain with highest striatal dopaminergic activation. Ipsiversive rotation indicates an action on the intact striatum, while contraversive rotation demonstrates an effect on dopamine receptors in the denervated striatum and is taken as predictive of symptomatic benefit in Parkinson
The BB (BioBreeding) rat is one of the best models of spontaneous autoimmune diabetes and is used to study non-MHC loci contributing to Type 1 diabetes. Type 1 diabetes in the diabetes-prone BB (BBDP) rat is polygenic, dependent upon mutations at several loci. Iddm1, on chromosome 4, is responsible for a lymphopenia (lyp) phenotype and is essential to diabetes. In this study, we report the positio
The purpose of this study was to test napsin A as a diagnostic marker of metastatic lung adenocarcinoma in pleural effusions, and to compare its performance with TTF-1. Napsin A and TTF-1 reactivities were determined immunohistochemically on.formalin-fixed paraffin embedded cell blocks from 50 pleural effusion (5 mesotheliomas, 10 mesothelial proliferations, 12 pulmonary, and 23 nonpulmonary metas
Attenuated total reflectance FTIR spectroscopy was used to characterize Al(III)-acetate complexation at 25 degrees C, in homogeneous aqueous solution and at the water-aluminum hydroxide interface. The data collected in aqueous solution, at [Al](tot) = 0.080 M, [OAc](tot) = 0.040 M, and pH < 4.3, indicate the presence of only one dominating complex which, by spectral analysis, is shown not to invol
Brent geese were tracked by satellite telemetry from spring staging areas in Denmark to Arctic breeding areas in Svalbard and Greenland in 1997 and 2001. From estimated departure masses and carcass analysis we used flight mechnical theory to estimate maximum flight ranges of both sexes, and remaining stores of fat and protein upon arrival in females. Model predictions suggested that all birds but
Background: The mechanisms underlying high-frequency QRS components (HF-QRS) are incompletely understood. One theory is that HF-QRS are related to the conduction velocity of the heart. The purpose was to test this hypothesis by comparing HF-QRS in patients with left or right bundle branch block (LBBB and RBBB, respectively) to those in healthy subjects and in patients with ischemic heart disease (
