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OBJECTIVE: MR (mineralocorticoid receptor) activation is associated with cardiovascular ischemia in humans. This study explores the role of the MR in atherosclerotic mice of both sexes and identifies a sex-specific role for endothelial cell (EC)-MR in vascular inflammation. Approach and Results: In the AAV-PCSK9 (adeno-associated virus-proprotein convertase subtilisin/kexin type 9) mouse atheroscl
Coprostanol was tested as ecological indicator to trace domestic and manure effluents and to investigate possible pollution sources in surface water. Pollution assessment was performed by analysing NO3 −, NO2 −, coprostanol (5β(H)-Cholestan-3β-ol), and cholestanol (5α(H)-Cholestan-3β-ol) in water samples from 42 sites along rivers in Shimabara and Unzen City, Japan. NO2-N concentration exceeded 0.
The crystalline lens of the vertebrate eye grows throughout life. This growth may be enormous in fish, while the lens must be functional from larva to adult. During growth, the fiber cells of the lens must increase the concentration of specific proteins (crystallins) in the cytoplasm to increase refractive index. However, the bulk of the fiber cells in a vertebrate lens are denucleated and have no
Motivation: Comparisons of microbiome communities across populations are often based on pairwise distance measures (beta-diversity). Standard analyses (principal coordinate plots, permutation tests, kernel methods) require access to primary data if another investigator wants to add or compare independent data. We propose using standard reference measurements to simplify microbiome beta-diversity a
The ability to capture alterations in the genome or transcriptome by next-generation sequencing has provided critical insight into molecular changes and programs underlying cancer biology. With the rapid technological development in single-cell sequencing, it has become possible to study individual cells at the transcriptional, genetic, epigenetic, and protein level. Using single-cell analysis, an
African governments have been faster than most of their European counterparts in imposing measures to deal with the COVID-19 outbreak despite dealing with numerous other challenges. However, context matters, and for Africa, the political and socioeconomic consequences of the lockdown measures may cause more havoc than the actual virus.This brief identifies political, economic and social risks rela
As physical distancing is a core measure of containing the spread of COVID-19, this pandemic is a crisis that has uprooted social interaction. While current research mainly focuses on crises as a challenge for entrepreneurial ventures and potential regulatory response mechanisms, we complement this research by addressing the question of how crises in general—and COVID-19's physical distancing meas
Extensive durability problems such as weathering and degradation are found in historic Scandinavian brick masonry buildings, especially from the neo-Gothic period. These are largely due to the crystallization of salts and frost action in the bricks and mortars. This article aims to show and illustrate which salts and crystals are found in historic brick masonry buildings and to describe their appe
Oceanic deoxygenation is increasingly affecting marine ecosystems; many taxa will be severely challenged, yet certain nominally aerobic foraminifera (rhizarian protists) thrive in oxygen-depleted to anoxic, sometimes sulfidic, sediments uninhabitable to most eukaryotes. Gene expression analyses of foraminifera common to severely hypoxic or anoxic sediments identified metabolic strategies used by t
Recurrent circuitry components are distributed widely within the brain, including both excitatory and inhibitory synaptic connections. Recurrent neuronal networks have potential stability problems, perhaps a predisposition to epilepsy. More generally, instability risks making internal representations of information unreliable. To assess the inherent stability properties of such recurrent networks,
Aquaporins (AQPs) are membrane channel proteins that facilitate the movement of water down osmotic gradients across biological membranes. This protocol allows measurements of AQP-mediated water transport across the plasma membrane of live mammalian cells. Calcein is a fluorescent dye that is quenched in a concentration-dependent manner. Therefore, on short timescales, its concentration-dependent f
Screening for atrial fibrillation (AF) with a handheld device for recording the ECG is becoming increasingly popular. The poorer signal quality of such ECGs may lead to false detection of AF, often caused by transient noise. Consequently, the need for expert review in AF screening can become extensive. A convolutional neural network (CNN) is proposed for transient noise identification in AF detect
Access to metabolic information in vivo using magnetic resonance (MR) technologies has generally been the niche of MR spectroscopy (MRS) and spectroscopic imaging (MRSI). Metabolic fluxes can be studied using the infusion of substrates labeled with magnetic isotopes, with the use of hyperpolarization especially powerful. Unfortunately, these promising methods are not yet accepted clinically, where
Study regionThis study focuses on the twelfth largest lake in Sweden, Lake Bolmen and its catchment.Study focusDuring the last decades the process of brownification has resulted in water with browner color, affecting water quality and ecosystems. The occurrence of brownification and its governing factors, especially with regard to the interaction with the environment, is not yet fully understood.
Background/Aim: To evaluate quality of life (QoL) in women treated for ovarian tumors one year after laparotomy. Patients and Methods: The validated quality of life questionnaires (EORTC QLQ-C30 and QLQ-OV28) were sent to women who had undergone laparotomy due to ovarian tumors 12 months after surgery. The answers were analyzed and grouped according to the ovarian tumor histology (benign, borderli
Objective: No dedicated studies have been performed on the optimal management of patients with an acute stroke related to carotid intervention nor is there a solid recommendation given in the European Society for Vascular Surgery guideline. By implementation of an international expert Delphi panel, this study aimed to obtain expert consensus on the optimal management of in hospital stroke occurrin
ObjectiveTo report the outcomes of redo fenestrated and/or branched endovascular aortic repair (F/BEVAR in FEVAR) to rescue previous failed FEVAR.MethodsRetrospective review of all consecutive patients undergoing F/BEVAR in FEVAR at eight aortic centres including pre-, intra-, and post-operative data according to a pre-established protocol. Follow up consisted of at least yearly computed tomograph
Introduction:It has been suggested that the future of diagnostic imaging relies on engagement inresearch and evidence-based practice. This implies a role transition from a clinical radiographer to aclinical radiographer-researcher. Clinical radiographers’stimuli for engaging in research in Nordiccountries are unknown. This study aimed to address this gap.Methods:Cross-sectional data collection via
