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BACKGROUND: The combined effect from the androgen receptor (AR) CAG and GGC length polymorphisms on testosterone levels has not been studied in young women. METHODS: Testosterone levels were measured in blood drawn on both menstrual cycle days 5-10 and 18-23 in 258 healthy women, aged <= 40 years, from high-risk breast cancer families. CAG and GGC length polymorphisms were analysed by PCR and frag
Variation of PCO2 with concomitant changes in extracellular pH (pHo) may modulate cerebrovascular resistance, but the direct actions of carbon dioxide and pHo on human cerebral arteries are unknown. In this study, we have evaluated the effects of different carbon dioxide tensions (2.7, 4.2 and 7.2 kPa) with either fixed (pHo = 7.44) or concomitant changes in pHo, on contractions induced by depolar
Apoptotic cells have been reported to down- regulate membrane-bound complement regulatory proteins ( m- C- Reg) and to activate complement. Nonetheless, most apoptotic cells do not undergo complement- mediated lysis. Therefore, we hypothesized that fluid phase complement inhibitors would bind to apoptotic cells and compensate functionally for the loss of m- C- Reg. We observed that m- C- Reg are d
The major theme underlying this symposium is the development and growth of many new forms of business associations over the last few decades. These new forms are characterized by a combination of personal freedom from partner/owner liability and far-reaching freedom of contract for partner/owners. The question thus becomes whether this development of new business associations amounts to an extensi
In order to correlate behavioural deficits to lesion size and to reveal possible functional asymmetries in the rat brain, locomotor activity, rotation and sensorimotor integration to touch were studied in spontaneously hypertensive rats (SHR) subjected to right or left middle cerebral artery occlusion. Control and infarcted rats showed no difference in locomotor activity. Infarcted rats tended to
Huntington's disease is an autosomal dominant hereditary neurodegenerative disorder characterized by severe striatal cell loss. Dopamine (DA) has been suggested to play a role in the pathogenesis of the disease. We have previously reported that transgenic mice expressing exon 1 of the human Huntington gene (R6 lines) are resistant to quinolinic acid-induced striatal toxicity. In this study we show
The primary aim of this study was to investigate the possible relationship between coagulation factor level and bleeding frequency during prophylactic treatment of haemophilia after stratification of the patients according to joint scores. The secondary aim was to obtain a systematic overview of the doses of coagulation factors prescribed for prophylaxis at the Malmo haemophilia treatment centre d
Popular Abstract in Swedish Globala internationella standards har stort inflyttande i var nutida teknikorienterade värld. Exemplen är många: vi kan importera och exportera produkter och tjänster i de flesta andra länder, vi kan kommunicera med andra personer var de än befinner sig, vi kan även resa snabbt och effektivt. Men skapande och underhåll av internationella standarder är ingen enkel procesStandards are used everywhere in the modern world and are a fundamental part of a functioning society. But the creation and maintenance of international standards is not an easy task. In addition to the technical prerequisites that must exist to create a standard, there are also political, economic and cultural aspects that must be considered. The present thesis does not interpret all these aspec
Four experiments manipulated the stimulus situation encountered by great tits on their feeding visits to the brood in order to explore its effect on feeding rate. Three broods containing 8, 8, and 10 nestlings were studied. A higher feeding rate was observed under the following conditions: (1) after a period of food deprivation, as compared with normal conditions and satiation through artifical fe
Design is often described as a profession where the result of the work is future oriented. Herbert Simon defined it as work that aims at “changing existing situations into preferred ones” . This may refer to a design process where the result can be very unpredictable even if the goal is thoroughly outlined. David Pye has portrayed this performance as “workmanship of risk” which differs from “workm
Zintl compounds form a category in intermetallic chemistry somewhere between metallic and ionic compounds. Classical Zintl compounds form between electropositive and electronegative elements, such as the alkaline earth metals and the p-block elements, i.e. elements with a relatively large electronegativity difference. The concept is based on the idea of a complete charge transfer from the electro
