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Immune checkpoint blockade (ICB) has improved outcome for patients with metastatic melanoma but not all benefit from treatment. Several immune- and tumor intrinsic features are associated with clinical response at baseline. However, we need to further understand the molecular changes occurring during development of ICB resistance. Here, we collect biopsies from a cohort of 44 patients with melanom

INTRODUCTION: We assessed whether macro- and/or micro-structural white matter properties are associated with cognitive resilience to Alzheimer's disease pathology years prior to clinical onset. METHODS: We examined whether global efficiency, an indicator of communication efficiency in brain networks, and diffusion measurements within the limbic network and default mode network moderate the associa

Caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), coronavirus disease 2019 (COVID-19) primarily manifests as respiratory dysfunction. However, emerging evidence suggests SARS-CoV-2 can invade the brain, leading to cognitive impairment (CI). It may spread to other brain regions through transsynaptic neurons, including the olfactory, optic, and vagus nerves. Moreover, it may in

In Sweden a new research project started in December 2009. The project focuses on light weight constructions and its sound insulation characteristics with respect to subjective response, and it will be carried out during the period of December 2009 to December 2012. The main goal is to develop new evaluation criteria proposals, for the low frequency range and vibrations and their mutual interactio

This contribution gives an overview of the Medium Resolution Imaging Spectrometer (MERIS) global land product corresponding to the biophysical variable of the Fraction of Absorbed Photo synthetically Active Radiation (FAPAR). This product can be used in large-scale biosphere modeling for better estimating the carbon fluxes since they directly represent the amount of solar energy which serves as a

In this talk we report on first results from the NLO computation of Z production in association with five jets in hadron-hadron collisions. The results are obtained with the help of the numerical method, where apart from the phase space integration also the integration over the loop momentum is performed numerically. In addition we discuss several methods and techniques for the improvement of the

This paper presents the findings of the workshop “New approaches to evacuation modelling”, which took place on the 11th of June 2017 in Lund (Sweden)within the Symposium of the International Association for Fire Safety Science (IAFSS). The workshop gathered international experts in the field of fire evacuation modelling from 19 different countries and was designed to build a dialogue between the f

Radiological evaluation of incidentally detected lung nodules on computed tomography (CT) influences management. We assessed international radiological variation in 1) pulmonary nodule characterisation; 2) hypothetical guideline-derived management; and 3) radiologists' management recommendations.107 radiologists from 25 countries evaluated 69 CT-detected nodules, recording: 1) first-choice composi

Background:After lung transplantation, life-long treatment with immunosuppressive medication is required to prevent rejection and graft loss but adherence to immunosuppressive treatment may be difficult for the lung recipient. Adherence is essential and non-adherence to immunosuppressive treatment can lead to graft loss and death.Objective:The aim of this cross-sectional study was to investigate t

This paper provides an update on the fast-evolving topic of the induced polarization (IP) method applied to biogeophysics. It emphasizes new understandings of the IP phenomena associated with biological activity, pointing out new developments and applications, and identifying existing knowledge gaps. The focus is on the use of IP as related to living organisms, including micro-organisms and plants

Type 2 (non-insulin-dependent) diabetes mellitus is a progressive metabolic disorder arising from genetic and environmental factors that impair beta cell function and insulin action in peripheral tissues. We identified reduced diacylglycerol kinase δ (DGKδ) expression and DGK activity in skeletal muscle from type 2 diabetic patients. In diabetic animals, reduced DGKδ protein and DGK kinase activit

Acute hypotensive episodes are common during dialysis sessions, and represent a serious problem. Spectral analysis of heart rate variability (HRV) and barorrefle x sensitivity (BRS) is performed to study the behaviour of the autonomic nervous system (ANS) during the hemodialysis. The ratio between the low frequency (LF) and high frequency (HF) power of HRV, as well as BRS in the HF band, are signi

Catchy slogans about tourism’s peace-promoting qualities abound—‘passport to peace’, ‘a vital force for peace’, and ‘the peace industry’, to name but a few. Yet, despite the critical scrutiny of the peace–tourism nexus in recent decades, its historical origins remain unexplored. This article traces the historical roots of the idea that tourism can help advance peace and international understanding

This study examined the effect of pregnancy on the host response to acute pyelonephritis. Urine and serum samples were obtained at the time of diagnosis and after two weeks, from non-pregnant and pregnant women with acute pyelonephritis. The samples were analyzed for interleukin-6 (IL-6) and specific antibody activity to antigens extracted from the Escherichia coli strain infecting each patient. T