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Treatment with metformin in type 2 diabetes mellitus-new routines when renal function is reduced and in connection with administration of iodine contrast media Metformin is eliminated through glomerular filtration and tubular secretion in the kidneys. New guidelines recommend use of metformin down to a GFR of 30 mL/min under the condition that the dose is adjusted. As the risk of inducing lactic a
Partially premixed combustion (PPC) is a hybrid combustion of Homogeneous Charge Compression Ignition (HCCI) and Diesel Combustion (DC), which has a great potential in reducing the fuel consumption. PPC has a longer premixed time than DC but lesser than HCCI. Therefore it is more stratified than HCCI. This paper first presents results on how the stratification using multiple injections and differe
The European Union is developing a common asylum system. The goal is to create certain minimum standards regulating the reception and procedures regarding asylum seekers and refugees. The Dublin II Regulation is one of the legal instruments created in this process. It determines which state is responsible for any particular asylum seeker and for their asylum application. The member state that allo
Abstract in UndeterminedIn this article, we present a constraint programming approach for solving hard design problems present when automatically designing specialized processor extensions. Specifically, we discuss our approach for automatic selection and synthesis of processor extensions as well as efficient application compilation for these newly generated extensions. The discussed approach is i
Internet of Things (IoT) devices can be equipped with multiple heterogeneous network interfaces. An overwhelmingly large amount of services may demand some or all of these interfaces’ available resources. Herein, we present a precise mathematical formulation of assigning services to interfaces with heterogeneous resources in one or more rounds. For reasonable instance sizes, the presented formulat
This book focuses on domain-specific heterogeneous reconfigurable architectures, demonstrating for readers a computing platform which is flexible enough to support multiple standards, multiple modes, and multiple algorithms. The content is multi-disciplinary, covering areas of wireless communication, computing architecture, and circuit design. The platform described provides real-time processing c
Heart transplantation (HT) is a life saving procedure, but a limited donor supply forces the surgeons to prioritize the recipients. The understanding of factors that predict mortality could help the doctors with this task. The objective of this study is to find locally optimal feature sets to predict survival of HT patients for different time periods. To this end, we applied logistic regression to
Embedded real-time systems must meet timing constraints while minimizing energy consumption. To this end, many energy optimizations are introduced for specific platforms or specific applications. These solutions are not portable, however, and when the application or the platform change, these solutions must be redesigned. Portable techniques are hard to develop due to the varying tradeoffs experie
Controllers with a diagonal-plus-low-rank structure constitute a scalable class of controllers for multi-agent systems. Previous research has shown that diagonal-plus-low-rank control laws appear as the optimal solution to a class of multi-agent H2 coordination problems, which arise in the control of wind farms. In this paper we show that this result extends to the case where the information excha
This paper focuses on the regulation of RNA production for in vitro synthetic gene networks. We consider the problem of matching the production rate of several RNA species concurrently transcribed to form RNA complexes. We design regulatory feedback loops based on two schemes: negative auto-regulation (which can minimize the potentially harmful amount of molecules not used to form products) and cr
Since over ten years, the Pordenone Silent Film Festival hosts masterclasses in which renowned pianists every day teaches, discusses and play silent films together with two selected young pianists who in this way get an intensive week of training the art of accompanying films. The masterclasses are open to the participators of the festival, and in this article we become part of the audience in fol
Natural resource management requires approaches to understand and handle sources of uncertainty in future responses of complex systems to human activities. Here we present one such approach, the "biological ensemble modeling approach,'' using the Eastern Baltic cod (Gadus morhua callarias) as an example. The core of the approach is to expose an ensemble of models with different ecological assumpti
In 2018, the strategy for Sweden’s National Forest Program emphasized the Swedish forests as green gold. A peculiar formulation that I in this study trace to the roots of the existing Forestry Act. Directly I deal with the question: how has the forest been represented in the Swedish forest policy shift of 1993? The overarching question is complemented by several questions included in the critical
A majority of the machining processes in the industry of today is performed using position-controlled machine tools, where conservative feed rates have to be used in order to avoid excessive process forces. By instead controlling the process forces, the feed rate, and consequently the material removal rate, can be maximized. In turn, this leads to decreased cycle times and cost savings. Furthermor
Objectives: A substantial proportion of individuals with stroke are of working age. After stroke, it is important to return to work (RTW), both for the individual's satisfaction with life and economically for society. The current comprehensive, long-term study aimed at investigating in what time period the RTW continues after stroke and what factors could predict RTW. Materials and methods: All in
In the 1990s the world economy was hit by a series of unusually deep crises with far-reaching consequences, the first of which occurred in Finland and Sweden. This paper compares the cost of the crisis of the 1990s with the costs caused by all major crises and depressions since the 1870s in the two Nordic countries. First, it constructs a crisis chronology for Finland and Sweden. Second, it estima
The building of sustainable innovation capabilities in Africa requires an innovation system capable of producing, disseminating and using new knowledge. This paper assesses the process of constructing the National Innovation System (NIS) in Rwanda. It is posited that consensus on and acceptance of the concept of NIS among stakeholders is crucial in the early process of constructing an efficient an
